Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

2001 • 3,292 citations

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

2004 • 2,779 citations

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

2004 • 1,836 citations

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

2001 • 1,714 citations

Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States

1999 • 734 citations

Selective degradation of oxidatively modified protein substrates by the proteasome

2003 • 457 citations

The ubiquitin‐proteasome pathway and proteasome inhibitors

2001 • 428 citations

What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

2001 • 412 citations

Mechanical Ventilation–induced Diaphragmatic Atrophy Is Associated with Oxidative Injury and Increased Proteolytic Activity

2002 • 338 citations

Regulation of Muscle Protein Degradation

2004 • 321 citations

Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes

2003 • 313 citations

Mechanical ventilation results in progressive contractile dysfunction in the diaphragm

2002 • 304 citations

Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy

1995 • 294 citations

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

1990 • 294 citations

Effects of mechanical ventilation on diaphragmatic contractile properties in rats.

1994 • 284 citations

Coordinate activation of lysosomal, Ca2+-activated and ATP-ubiquitin-dependent proteinases in the unweighted rat soleus muscle

1996 • 278 citations

Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress

2002 • 242 citations

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1995 • 228 citations

Free radicals may contribute to oxidative skeletal muscle fatigue

1991 • 214 citations

Trolox Attenuates Mechanical Ventilation–induced Diaphragmatic Dysfunction and Proteolysis

2004 • 203 citations

Altered proteasome function and subunit composition in aged muscle

2003 • 197 citations

Effects of prolonged controlled mechanical ventilation on diaphragmatic function in healthy adult baboons

1997 • 195 citations

Space shuttle flight (STS‐90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin‐proteasome pathway

2001 • 187 citations

Mechanical ventilation-induced oxidative stress in the diaphragm

2003 • 186 citations

Oxidative stress in skeletal muscle atrophied by immobiIization

1991 • 152 citations

Mechanical Ventilation Depresses Protein Synthesis in the Rat Diaphragm

2004 • 146 citations

Human respiratory muscles: fibre morphology and capillary supply

1991 • 139 citations

Kinetic Characterization of the Chymotryptic Activity of the 20S Proteasome

1996 • 137 citations

14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin

1994 • 127 citations

Age-related changes in the 20S and 26S proteasome activities in the liver of male F344 rats

1998 • 125 citations

The Ubiquitin-Proteasome Pathway

1997 • 100 citations

Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis

1999 • 97 citations

Changes in 20S proteasome activity during ageing of the LOU rat.

1999 • 71 citations

The Circadian Clock: A Manager of Biochemical Processes Within the Organism

2003 • 64 citations

Cumulative Effects of Aging and Mechanical Ventilation on In Vitro Diaphragm Function

2003 • 62 citations

Short-Duration Mechanical Ventilation Enhances Diaphragmatic Fatigue Resistance but Impairs Force Production

2003 • 61 citations

Cysteine Supplementation Prevents Unweighting-Induced Ubiquitination in Association with Redox Regulation in Rat Skeletal Muscle

2002 • 61 citations

Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle

2000 • 44 citations

Distribution of Proteasomes and of the Five Proteolytic Activities in Rat Tissues

2000 • 44 citations

Myosin phenotype and bioenergetic characteristics of rat respiratory muscles

1997 • 42 citations

Sepsis is associated with increased ubiquitinconjugating enzyme E2_14k mRNA in skeletal muscle

1999 • 38 citations

Assays of proteasome activity in relation to aging

2002 • 33 citations

Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle.

1997 • 32 citations

Difficult weaning from mechanical ventilation

1990 • 14 citations

Coordinate upregulation of proteolytic-related genes in rat muscle during late fasting

2003 • 12 citations