Aliskiren, a Novel Orally Effective Renin Inhibitor, Provides Dose-Dependent Antihypertensive Efficacy and Placebo-Like Tolerability in Hypertensive Patients

A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure

2001 • 3,065 citations

Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both

2003 • 2,402 citations

Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme

2003 • 1,862 citations

Microalbuminuria Reduction With Valsartan in Patients With Type 2 Diabetes Mellitus

2002 • 794 citations

The Effect of Prescribed Daily Dose Frequency on Patient Medication Compliance

1990 • 788 citations

Tissue Angiotensin and Pathobiology of Vascular Disease

2001 • 750 citations

Structure-based design of aliskiren, a novel orally effective renin inhibitor

2003 • 499 citations

Drugs targeting the renin–angiotensin–aldosterone system

2002 • 425 citations

Angiotensin II Suppression in Humans by the Orally Active Renin Inhibitor Aliskiren (SPP100)

2002 • 409 citations

Pathways for Angiotensin II Generation in Intact Human Tissue

1998 • 338 citations

Blood Pressure Lowering in Essential Hypertension With an Oral Renin Inhibitor, Aliskiren

2003 • 338 citations

Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin

2000 • 310 citations

Pharmacokinetics and Pharmacodynamics of Irbesartan in Healthy Subjects

1998 • 73 citations

Calcium antagonists and renal protection

1993 • 72 citations

Is there a future for renin inhibitors?

2001 • 69 citations

Review: Potential of renin inhibition in cardiovascular disease

2003 • 66 citations

Cough and inhibition of the renin-angiotensin system.

1993 • 62 citations

Low-dose combination therapy: an important first-line treatment in the management of hypertension

2001 • 60 citations

Pharmacology of renin inhibitors and their application to the treatment of hypertension

1994 • 46 citations

Irbesartan

2000 • 44 citations

Renin inhibitors as novel treatments for cardiovascular disease

2003 • 43 citations

Clinical Pharmacokinetics and Efficacy of Renin Inhibitors

1995 • 38 citations

Alterations in cytosolic calcium-binding proteins that increase felodipine fluorescence in spontaneously hypertensive rats

1993 • 14 citations

Role of trough to peak efficacy in the evaluation of antihypertensive therapy.

1998 • 7 citations