The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

1996 • 1,516 citations

Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.

1993 • 1,395 citations

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

1995 • 1,252 citations

Mechanism and regulation of human non-homologous DNA end-joining

2003 • 957 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

A quantitative assay for HIV DNA integration in vivo

2001 • 692 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

2001 • 494 citations

A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes

2002 • 472 citations

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

1991 • 392 citations

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

2001 • 351 citations

HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection

1998 • 332 citations

ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

2001 • 289 citations

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

2003 • 273 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

A Role for DNA-PK in Retroviral DNA Integration

1999 • 255 citations

Analysis of Early Human Immunodeficiency Virus Type 1 DNA Synthesis by Use of a New Sensitive Assay for Quantifying Integrated Provirus

2003 • 213 citations

A Sensitive, Quantitative Assay for Human Immunodeficiency Virus Type 1 Integration

2002 • 212 citations

HIV-1 Infection Requires a Functional Integrase NLS

2001 • 201 citations

Repair of Gaps in Retroviral DNA Integration Intermediates

2000 • 198 citations

Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R

2003 • 196 citations

Integration is essential for efficient gene expression of human immunodeficiency virus type 1

1993 • 195 citations

Cell Cycle Arrest by Vpr in HIV-1 Virions and Insensitivity to Antiretroviral Agents

1998 • 190 citations

Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain

1995 • 154 citations

Slipping through the door: HIV entry into the nucleus

2002 • 143 citations

Human Immunodeficiency Virus Type 1 Vpr Is a Positive Regulator of Viral Transcription and Infectivity in Primary Human Macrophages

1998 • 140 citations

Roles of host cell factors in circularization of retroviral dna

2003 • 122 citations

Human Immunodeficiency Virus Type 1 Vpr-Mediated G₂ Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation

2004 • 115 citations

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection

1999 • 110 citations

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

2003 • 100 citations

Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNA

2003 • 100 citations

BCR First Exon Sequences Specifically Activate the BCR/ABL Tyrosine Kinase Oncogene of Philadelphia ChromosomePositive Human Leukemias

1991 • 97 citations

DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration

2000 • 95 citations

Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr

1995 • 91 citations

Wortmannin Potentiates Integrase-Mediated Killing of Lymphocytes and Reduces the Efficiency of Stable Transduction by Retroviruses

2001 • 79 citations

An Inducible Human Immunodeficiency Virus Type 1 (HIV-1) Vector Which Effectively Suppresses HIV-1 Replication

1999 • 77 citations

Role of HIV-1 Vpr in AIDS pathogenesis: relevance and implications of intravirion, intracellular and free Vpr

2003 • 66 citations

Accumulation and Intranuclear Distribution of Unintegrated Human Immunodeficiency Virus Type 1 DNA

2001 • 61 citations

Detection of β‐lactamase reporter gene expression by flow cytometry

2003 • 31 citations