Histone H2AX Is Phosphorylated at Sites of Retroviral DNA Integration but Is Dispensable for Postintegration Repair

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

H2AX: the histone guardian of the genome

2004 • 978 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

Recombinational DNA double-strand breaks in mice precede synapsis

2001 • 853 citations

Histone H2A variants H2AX and H2AZ

2002 • 749 citations

DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

2002 • 653 citations

H2AX Is Required for Chromatin Remodeling and Inactivation of Sex Chromosomes in Male Mouse Meiosis

2003 • 582 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

2002 • 529 citations

THE RETROVIRAL ENZYMES

1994 • 517 citations

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2001 • 496 citations

Histone H2AX

2003 • 479 citations

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

2003 • 354 citations

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

2000 • 315 citations

NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain

2002 • 306 citations

Similarities Between Initiation of V(D)J Recombination and Retroviral Integration

1996 • 280 citations

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

2003 • 277 citations

A Role for DNA-PK in Retroviral DNA Integration

1999 • 255 citations

HIF-1: A Target For Cancer, Ischemia and Inflammation—Too Good to be True?

2004 • 251 citations

H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity

2004 • 169 citations

Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells

1999 • 167 citations

Evidence that Stable Retroviral Transduction and Cell Survival following DNA Integration Depend on Components of the Nonhomologous End Joining Repair Pathway

2004 • 101 citations

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

2003 • 100 citations

Kinetics of Human Immunodeficiency Virus Type 1 (HIV) DNA Integration in Acutely Infected Cells as Determined Using a Novel Assay for Detection of Integrated HIV DNA

2001 • 96 citations

Wortmannin Potentiates Integrase-Mediated Killing of Lymphocytes and Reduces the Efficiency of Stable Transduction by Retroviruses

2001 • 79 citations

Autoubiquitylation of the V(D)J recombinase protein RAG1

2003 • 74 citations

Transduction of Interphase Cells by Avian Sarcoma Virus

2002 • 64 citations

HumanImmunodeficiency Virus Type 1 DNA Nuclear Import and Integration AreMitosis Independent in CyclingCells

2003 • 59 citations