Rapid Release of Antipsychotic Drugs From Dopamine D₂ Receptors: An Explanation for Low Receptor Occupancy and Early Clinical Relapse Upon Withdrawal of Clozapine or Quetiapine

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

Quantitative Analysis of D2 Dopamine Receptor Binding in the Living Human Brain by PET

1986 • 847 citations

Clinical and Theoretical Implications of 5-HT₂ and D₂ Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia

1999 • 706 citations

Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs

1988 • 692 citations

Dopamine D4 receptors elevated in schizophrenia

1993 • 632 citations

Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: A double-blind PET study of schizophrenic patients

1993 • 529 citations

D2 Dopamine Receptors in Neuroleptic-Naive Schizophrenic Patients

1990 • 526 citations

Neuroleptic Withdrawal in Schizophrenic Patients

1995 • 436 citations

Overview: maintenance therapy in psychiatry: I. Schizophrenia

1975 • 414 citations

5-HT₂ and D₂ Receptor Occupancy of Olanzapine in Schizophrenia: A PET Investigation

1998 • 364 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics

1989 • 322 citations

Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors

1998 • 293 citations

Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides

1996 • 266 citations

Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum

1992 • 258 citations

High levels of dopamine D2 receptor occupancy with low-dose haloperidol treatment: a PET study

1996 • 257 citations

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A pet study

1995 • 237 citations

Atypical Neuroleptics Have Low Affinity for Dopamine D2 Receptors or Are Selective for D4 Receptors

1997 • 235 citations

5-HT2 and D2 dopamine receptor occupancy in the living human brain

1993 • 228 citations

Neuroleptic-induced supersensitivity psychosis

1978 • 219 citations

Clozapine, single photon emission tomography, and the D2 dopamine receptor blockade hypothesis of schizophrenia

1992 • 207 citations

Stereoselective binding of 11C-raclopride in living human brain ? a search for extrastriatal central D2-dopamine receptors by PET

1988 • 202 citations

Neuroleptic Withdrawal in Schizophrenic Patients

1995 • 200 citations

Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.

1993 • 183 citations

Variability in D₂‐dopamine receptor density and affinity: A PET study with [¹¹C]raclopride in man

1995 • 176 citations

Cooperativity Manifest in the Binding Properties of Purified Cardiac Muscarinic Receptors

1995 • 172 citations

Time course of central nervous dopamine-D 2 and 5-HT 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel ® ) in patients with schizophrenia

1998 • 167 citations

Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol

1992 • 160 citations

Positron Emission Tomography Studies on D2 and 5-HT2 Receptor Binding in Risperidone-Treated Schizophrenic Patients

1995 • 156 citations

In vivo SPECT imaging of CNS D-2 dopamine receptors: initial studies with iodine-123-IBZM in humans.

1990 • 141 citations

The relationship between D 2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study

1997 • 126 citations

Dopamine D2 receptor occupancy in vivo by the novel atypical antipsychotic olanzapine — a123 IBZM single photon emission tomography (SPET) study

1996 • 124 citations

An open label trial of raclopride in acute schizophrenia. Confirmation of D2-dopamine receptor occupancy by PET

1988 • 112 citations

High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET

1993 • 108 citations

PET Analysis Indicates Atypical Central Dopamine Receptor Occupancy in Clozapine-Treated Patients

1992 • 107 citations

Cholinergic Rebound and Rapid Onset Psychosis Following Abrupt Clozapine Withdrawal

1996 • 100 citations

Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels

1997 • 99 citations

PET Evidence That Loxapine Is an Equipotent Blocker of 5-HT₂and D₂Receptors: Implications for the Therapeutics of Schizophrenia

1997 • 96 citations

Cardiac Muscarinic Receptors. Cooperativity as the Basis for Multiple States of Affinity

1997 • 92 citations

Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal

1984 • 89 citations

Clozapine Withdrawal Resulting in Delirium With Psychosis

1997 • 86 citations

The time course of binding to striatal dopamine D2 receptors by the neuroleptic ziprasidone (CP-88,059-01) determined by positron emission tomography

1996 • 84 citations

D1-, D2-, and 5-HT2-receptor occupancy in clozapine-treated patients.

1994 • 83 citations

Deriving the therapeutic concentrations for clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand

1995 • 73 citations

IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol

1997 • 68 citations

Positron emission tomography studies on D2 dopamine receptor occupancy and plasma antipsychotic drug levels in man

1995 • 68 citations

Relapse following clozapine withdrawal: effect of neuroleptic drugs and cyproheptadine

1996 • 67 citations

Measuring dopamine transporter occupancy by cocaine in vivo: Radiotracer considerations

1998 • 67 citations

Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM.

1992 • 66 citations

D2‐dopamine receptor occupancy differs between patients with and without extrapyramidal side effects

1994 • 60 citations

Individual variation in D2 dopamine receptor occupancy in clozapine- treated patients

1996 • 58 citations

[123I]IBZM SPECT for imaging of striatal D2 dopamine receptors in 56 schizophrenic patients taking various neuroleptics

1996 • 57 citations

Regional and Cortical Laminar Distributions of Serotonin S₂, Benzodiazepine, Muscarinic, and Dopamine D₂ Receptors in Human Brain

1984 • 52 citations

Sertindole and dopamine D 2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - a 123 I-IBZM SPECT study

1998 • 52 citations

Dopamine D2 receptor blockade in vivo with the novel antipsychotics risperidone and remoxipride — an123I-IBZM single photon emission tomography (SPET) study

1995 • 51 citations

NIMH Activities: Clinical Implications of Clozapine Discontinuation: Report of an NIMH Workshop

1995 • 50 citations

Therapeutic receptor-blocking concentrations of neuroleptics

1995 • 39 citations

Dopamine and Serotonin Receptors: Amino Acid Sequences, and Clinical Role in Neuroleptic Parkinsonism

1996 • 39 citations

The D2 Receptor Occupancy Profile of Loxapine Determined Using PET

1996 • 37 citations

The Dissociation Rate of Unlabelled Dopamine Antagonists and Agonists from the Dopamine-D²Receptor, Application of an Original Filter Method

1984 • 37 citations

Failure of the three compartment model to describe the pharmacokinetics in brain of a high affinity substituted benzamide

1993 • 33 citations

In vitro and in vivo D2-dopamine receptor binding with [123I]S(−)iodobenzamide ([123I]IBZM) in rat and human brain

1991 • 31 citations

Evaluation of the importance of rebinding to receptors in slowing the approach to equilibrium of high-affinity PET and SPECT radiotracers

1998 • 28 citations

D2 occupancy, extrapyramidal side effects and antipsychotic drug treatment

1997 • 21 citations

Previous treatment as a confounding variable in studies with novel antipsychotics: two cases of high dopamine-2 receptor occupancy with quetiapine

1997 • 19 citations

Effect of Melperone, Two of its Metabolites and Thiothixene on Central Monoamine Metabolism and Prolactin Levels in Rodents

1978 • 18 citations

P-4-65 Time course for dopamine and serotonin receptor occupancy in the brain of schizophrenic patients following dosing with 150 mg Seroquel™ tid

1995 • 17 citations

[123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effects

1997 • 14 citations

A simple and high‐yield synthesis of (S)‐BZM, (R)‐BZM AND (S)‐IBZM for the preparation of (S)‐¹²³I‐IBZM

1990 • 13 citations

Displacement of RTI-55 from the dopamine transporter by cocaine

1996 • 12 citations

Hypothesis testing: Is clozapine's superior efficacy dependent on moderate D2 receptor occupancy?

1998 • 12 citations

Immediate recurrence of psychotic symptoms after discontinuation of clozapine: A case report

1996 • 10 citations

D2 Receptor occupancy in risperidone and clozapine-treated schizophrenics

1996 • 9 citations

Deriving the therapeutic concentrations for clozapine and haloperidol: The apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand

1995 • 7 citations

Time course for dopamine and serotonin receptor occupancy in the brain of schizophrenic patients following dosing with 150 mg ‘seroquel’ TID

1996 • 7 citations

Dopamine-2 receptor imaging in psychotic patients treated with quetiapine, clozapine, risperidone and haloperidol

1997 • 6 citations

IBZM SPECT measurement of D2 receptor occupancy by haloperidol and risperidone

1996 • 5 citations

P.2.111 D2 and 5 HT2A receptor binding of different doses of quetiapine in schizophrenics, a pet study

1997 • 3 citations

Striatal dopamine D2 receptor occupancy in patients treated with olanzapine

1998 • 2 citations

5HT2 and D2 receptor occupancy of ziprasidone in healthy volunteers

1997 • 1 citations