PET Evidence That Loxapine Is an Equipotent Blocker of 5-HT₂and D₂Receptors: Implications for the Therapeutics of Schizophrenia

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding

1996 • 1,143 citations

Serotonin-dopamine interaction and its relevance to schizophrenia

1996 • 822 citations

Effects of Age on Dopamine and Serotonin Receptors Measured by Positron Tomography in the Living Human Brain

1984 • 701 citations

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

1994 • 592 citations

Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors

1987 • 569 citations

Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

1993 • 510 citations

Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

1987 • 342 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors

1993 • 334 citations

The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs.

1989 • 321 citations

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A pet study

1995 • 237 citations

Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.

1993 • 170 citations

D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs

1995 • 143 citations

A Method for the In Vivo Investigation of the Serotonergic 5‐HT₂ Receptors in the Human Cerebral Cortex Using Positron Emission Tomography and ¹⁸F‐Labeled Setoperone

1990 • 110 citations

[18F]Setoperone: A new high-affinity ligand for positron emission tomography study of the serotonin-2 receptors in baboon brain in vivo

1988 • 95 citations

The Role of Serotonin in Schizophrenia and the Place of Serotonin-Dopamine Antagonist Antipsychotics

1995 • 77 citations

Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain

1984 • 74 citations

Common pharmacological and physico-chemical properties of 5-HT3 binding sites in the rat cerebral cortex and NG 108-15 clonal cells

1990 • 67 citations

Labeling of a serotoninergic ligand with ¹⁸F : [¹⁸F] setoperone

1988 • 46 citations

Therapeutic receptor-blocking concentrations of neuroleptics

1995 • 39 citations

Estimation of neocortical serotonin-2 receptor binding potential by single-dose fluorine-18-setoperone kinetic PET data analysis.

1996 • 38 citations

The D2 Receptor Occupancy Profile of Loxapine Determined Using PET

1996 • 37 citations

A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes.

1996 • 35 citations

Unusual acute effects of antidepressants and neuroleptics on S2-serotonergic receptors

1983 • 32 citations

Reliability of a simple non-invasive method for the evaluation of 5-HT2 receptors using [18F]-setoperone PET imaging

1997 • 30 citations

3H-spiroperidol binding to dopamine receptors in rat striatal membranes: Influence of loxapine and its hydroxylated metabolites

1979 • 26 citations

The role of metabolites in a bioequivalence study II: amoxapine, 7-hydroxyamoxapine, and 8-hydroxyamoxapine.

1999 • 21 citations

Measurement of [11C]Raclopride Binding Using a Bolus plus Infusion Protocol

1996 • 9 citations

A neurochemical basis for the antipsychotic activity of loxapine: Interactions with dopamine D1, D2, D4, and serotonin 5-HT2 receptor subtypes

1996 • 8 citations

Investigation of the Dopamine System with Positron Emission Tomography: General Issues in Modelling

1991 • 8 citations