Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by (−)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Vitamin D

1979 • 3,814 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Wnt signaling and cancer

2000 • 3,215 citations

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

2000 • 2,569 citations

World Cancer Report

2003 • 2,484 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Inhibition of Carcinogenesis by Tea

2002 • 947 citations

Colorectal Cancer: Molecules and Populations

1999 • 894 citations

Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling

2001 • 783 citations

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion

2003 • 631 citations

The cadherin-catenin adhesion system in signaling and cancer

2002 • 541 citations

Autoregulation of E-cadherin expression by cadherin–cadherin interactions

2003 • 462 citations

The cadherin-catenin adhesion system in signaling and cancer

2002 • 448 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.

2000 • 309 citations

Epigallocatechin-3-Gallate Is Absorbed but Extensively Glucuronidated Following Oral Administration to Mice

2003 • 295 citations

Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.

2003 • 285 citations

Tea and Cancer Prevention: Studies in Animals and Humans

2003 • 277 citations

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system.

2003 • 267 citations

Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma

2002 • 232 citations

Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation.

2003 • 212 citations

Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.

1998 • 204 citations

Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea.

1997 • 176 citations

Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention

2004 • 168 citations

Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis.

2000 • 148 citations

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.

1995 • 147 citations

Inhibition of Azoxymethane‐induced Colon Carcinogenesis in Rat by Green Tea Polyphenol Fraction

1991 • 143 citations

Coffee, Tea, and Caffeine Consumption and Incidence of Colon and Rectal Cancer

2005 • 142 citations

Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes

2000 • 134 citations

Inhibition of β-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H2O2 at physiologically relevant EGCG concentrations

2002 • 124 citations

Suppression of tumorigenesis in the Apcmin mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac

2003 • 117 citations

Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma

2003 • 113 citations

Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat.

2001 • 111 citations

Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice

2004 • 110 citations

Coffee, Decaffeinated Coffee, Tea and Cancer of the Colon and Rectum: A Review of Epidemiological Studies, 1990–2003

2004 • 101 citations

Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis.

2003 • 95 citations

Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice

2001 • 95 citations

Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine

1994 • 80 citations

Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo.

2001 • 72 citations

Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2′-dihydroxy-di-n-propylnitrosamine in male F344 rats

2001 • 68 citations

Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice

2001 • 59 citations

Information Of Lung Tumorigenesis By Tea

2004 • 58 citations

Effect of Tea Extracts, Polyphenols, and Epigallocatechin Gallate on Azoxymethane-induced Colon Cancer

1998 • 49 citations

Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer.

1998 • 47 citations

Organ‐dependent Modifying Effects of Caffeine, and Two Naturally Occurring Antioxidants α‐Tocopherol and n‐Tritriacontane‐16,18‐dione, on 2‐Amino‐1‐methyl‐6‐phenylimidazo [4,5‐b] pyridine (PhIP)‐induced Mammary and Colonic Carcinogenesis in Female F344 Rats

1999 • 35 citations

Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats

1999 • 33 citations

The Citrus Methoxyflavone Tangeretin Affects Human Cell-Cell Interactions

2002 • 33 citations

Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses

2002 • 26 citations

Analysis of beta-catenin, Ki-ras, and microsatellite stability in azoxymethane-induced colon tumors of BDIX/Orl Ico rats.

2003 • 3 citations