Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Cancer statistics, 1999

1999 • 3,154 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1995 • 585 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

1996 • 466 citations

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

1985 • 396 citations

Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice

1991 • 304 citations

Reduced E-Cadherin Expression is Associated With Invasiveness and Unfavorable Prognosis in Breast Cancer

1996 • 302 citations

Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinomain situ

1997 • 299 citations

Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane

1998 • 285 citations

Indole-3-carbinol Inhibits the Expression of Cyclin-dependent Kinase-6 and Induces a G1 Cell Cycle Arrest of Human Breast Cancer Cells Independent of Estrogen Receptor Signaling

1998 • 279 citations

A simple quantitative assay for studying the invasive potential of high and low human metastatic variants

1987 • 243 citations

Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells.

1998 • 242 citations

The E-cadherin/Catenin Complex in Invasion and Metastasis

1996 • 227 citations

Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells

1996 • 219 citations

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility

1999 • 209 citations

E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model.

1996 • 193 citations

E-cadherin and α-, β-, and γ-catenin protein expression in relation to metastasis in human breast carcinoma

1998 • 185 citations

Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice

1980 • 166 citations

Altered estrogen metabolism and excretion in humans following consumption of indole‐3‐carbinol

1991 • 155 citations

Mechanisms of inactivation of E-cadherin in breast cancer cell lines.

1998 • 148 citations

Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.

1995 • 141 citations

Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.

1999 • 139 citations

Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice.

1999 • 136 citations

Selective Responsiveness of Human Breast Cancer Cells to Indole-3-carbinol, a Chemopreventive Agent

1994 • 136 citations

Indolo[3, 2-b]carbazole: a Dietary-Derived Factor That Exhibits Both Antiestrogenic and Estrogenic Activity

1994 • 126 citations

An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers

1998 • 121 citations

Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype.

1994 • 115 citations

Dose-ranging study of Indole-3-Carbinol for breast cancer prevention

1997 • 114 citations

17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane.

1986 • 113 citations

BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteins

1998 • 100 citations

Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer.

1999 • 95 citations

Expression of E-cadherin and catenins in invasive mammary carcinomas.

1997 • 93 citations

Loss of E-cadherin expression associated with lymph node metastases in small breast carcinomas

1997 • 87 citations

Prevention of breast cancer growth, invasion, and metastasis by antiestrogen tamoxifen alone or in combination with urokinase inhibitor B-428.

1997 • 84 citations

Inhibition of Proliferation and Modulation of Estradiol Metabolism: Novel Mechanisms for Breast Cancer Prevention by the Phytochemical Indole-3-Carbinol

1997 • 83 citations

Reduced E-Cadherin Immunohistochemical Expression in Node-Negative Breast Carcinomas Correlates With 10-Year Survival

1998 • 70 citations

BRCA1 expression levels predict distant metastasis of sporadic breast cancers

1999 • 66 citations

Control of cell locomotion: perturbation with an antibody directed against specific glycoproteins

1985 • 55 citations

Effect of host age on the transplantation, growth, and radiation response of EMT6 tumors.

1981 • 48 citations

Influence of indole-3-carbinol on the hepatic microsomal formation of catechol estrogens

1991 • 41 citations

Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion

1997 • 38 citations

Estrogen Activates Migration Potential of Endometrial Cancer Cells through Basement Membrane

1996 • 27 citations

Molecular and endocrine biomarkers in non-involved breats: Relevance to cancer chemoprevention

1992 • 25 citations

Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.

1997 • 16 citations

Inhibition of endothelial adhesion and invasion by breast carcinoma cells may contribute towards the anti-metastatic effects of tamoxifen

1996 • 4 citations