Metalloprotease-mediated GH Receptor Proteolysis and GHBP Shedding

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Construction of adenovirus vectors through Cre-lox recombination

1997 • 807 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

1999 • 558 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

2002 • 415 citations

The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.

1989 • 399 citations

Tumor necrosis factor-α converting enzyme

2002 • 341 citations

Molecular Mechanism of Growth Hormone Action

1996 • 309 citations

Mouse Serum Growth Hormone (GH) Binding Protein has GH Receptor Extracellular and Substituted Transmembrane Domains

1989 • 305 citations

A Short Isoform of the Human Growth Hormone Receptor Functions as a Dominant Negative Inhibitor of the Full-Length Receptor and Generates Large Amounts of Binding Protein

1997 • 215 citations

The Τumor Necrosis Factor-α Converting Enzyme (TACE): A Unique Metalloproteinase with Highly Defined Substrate Selectivity

2002 • 195 citations

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor

1999 • 194 citations

The Circulating Growth Hormone (GH)-Binding Protein Complex: A Major Constituent of Plasma GH in Man*

1988 • 172 citations

Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein.

1996 • 145 citations

Regulation of plasma growth hormone-binding proteins in health and disease

1989 • 145 citations

Evidence for generation of the growth hormone-binding protein through proteolysis of the growth hormone membrane receptor.

1993 • 142 citations

Growth Hormone Binding Protein 2001

2001 • 140 citations

Tumor Necrosis Factor-α Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation*

2000 • 139 citations

Nuclear translocation and anchorage of the growth hormone receptor.

1994 • 131 citations

Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase.

1994 • 127 citations

Identification of the Origin of the Growth Hormone-Binding Protein in Rat Serum

1990 • 111 citations

Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization

1999 • 99 citations

Growth Hormone (GH)-induced Dimerization Inhibits Phorbol Ester-stimulated GH Receptor Proteolysis

2001 • 91 citations

Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.

1996 • 90 citations

Identification of Phenylalanine 346 in the Rat Growth Hormone Receptor as Being Critical for Ligand-mediated Internalization and Down-regulation

1995 • 84 citations

Demonstration of Direct Effects of Growth Hormone on Neonatal Cardiomyocytes

2001 • 80 citations

Blockade of Growth Hormone Receptor Shedding by a Metalloprotease Inhibitor*

1998 • 72 citations

Growth Hormone-Dependent Tyrosine Phosphorylation of a GH Receptor-Associated High Molecular WEIGHT Protein Immunologically Related to JAK2

1998 • 62 citations

Phorbol Ester- and Growth Factor-Induced Growth Hormone (GH) Receptor Proteolysis and GH-Binding Protein Shedding: Relationship to GH Receptor Down-Regulation¹

2001 • 46 citations

The Ubiquitin-Proteasome Pathway Regulates the Availability of the GH Receptor

2002 • 41 citations

Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3–dependent myeloid progenitor cells

2000 • 41 citations

Metalloproteinases and the modulation of GH signaling

2002 • 40 citations

Human growth hormone (GH) receptor is characterized as the 134-kilodalton tyrosine-phosphorylated protein activated by GH treatment in IM-9 cells.

1993 • 37 citations

Shedding of growth hormone-binding protein is inhibited by hydroxamic acid-based protease inhibitors: proposed mechanism of activation of growth hormone-binding protein secretase

2001 • 22 citations

Identification of a Region Critical for Proteolysis of the Human Growth Hormone Receptor

2002 • 17 citations