Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Differences in fear motivated behaviors among inbred mouse strains

1993 • 450 citations

The neuropharmacological and neurochemical basis of place learning in the Morris water maze

1993 • 430 citations

Generalized autoimmune disease in interleukin‐2‐deficient mice is triggered by an uncontrolled activation and proliferation of CD4⁺ T cells

1995 • 423 citations

Interleukin-2 as a neuroregulatory cytokine

1995 • 209 citations

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

1989 • 179 citations

Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

1995 • 151 citations

T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.

1995 • 149 citations

Behavioural performance in three substrains of mouse strain 129

1997 • 144 citations

Correlations between radial-maze learning and structural variations of septum and hippocampus in rodents

1995 • 136 citations

Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus

1990 • 123 citations

Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse

1991 • 122 citations

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

1991 • 111 citations

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors

1994 • 111 citations

Modulation of behavioral and neurochemical measures of forebrain dopamine function in mice by species-specific interleukin-2

1997 • 108 citations

Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2

1993 • 107 citations

Water-maze learning in the mouse correlates with variation in hippocampal morphology

1988 • 94 citations

Interleukin-2 does not cross the blood-brain barrier by a saturable transport system

1994 • 86 citations

Interleukin‐2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain

1993 • 76 citations

Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain

1993 • 72 citations

Comparative effect of IL-2 and IL-6 on morphology of cultured hippocampal neurons from fetal rat brain

1996 • 58 citations

Interleukin‐2 Transcripts in Human and Rodent Brains: Possible Expression by Astrocytes

1995 • 56 citations

The septohippocampal system is involved in prepulse inhibition of the acoustic startle response in rats.

1996 • 52 citations

Induction of Fos-protein in the forebrain and disruption of sensorimotor gating following N-methyl-d-aspartate infusion into the ventral hippocampus of the rat

1998 • 50 citations

Molecular cloning of a partial cDNA of the interleukin-2 receptor-β in normal mouse brain: in situ localization in the hippocampus and expression by neuroblastoma cells

1994 • 49 citations

The septohippocampal system is involved in prepulse inhibition of the acoustic startle response in rats.

1996 • 43 citations

Evidence for direct and indirect mechanisms in the potent modulatory action of interleukin‐2 on the release of acetylcholine in rat hippocampal slices

1997 • 41 citations

Molecular cloning of the cDNA coding sequence of IL-2 receptor-γ (γc) from human and murine forebrain: Expression in the hippocampus in situ and by brain cells in vitro

1998 • 36 citations

Molecular cloning of IL‐2Rα, IL‐2Rβ, and IL‐2Rγ cDNAs from a human oligodendroglioma cell line: Presence of IL‐2R mRNAs in the human central nervous system

1995 • 23 citations

Molecular cloning of the coding sequence of an interleukin-2 receptor α subunit cDNA in murine brain

1995 • 18 citations

Induction of Autoimmune Myocarditis in Interleukin-2–Deficient Mice

1997 • 18 citations