Regulation of Gene Expression by 1α,25-Dihydroxyvitamin D₃and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

The Significance of Digital Gene Expression Profiles

1997 • 2,723 citations

Head and Neck Cancer

1993 • 2,263 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

1998 • 1,391 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

Current Understanding of the Molecular Actions of Vitamin D

1998 • 1,259 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations

2000 • 880 citations

Proliferating cell nuclear antigen is required for DNA excision repair

1992 • 809 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1

1999 • 558 citations

Genomic instability in Gadd45a-deficient mice

1999 • 499 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

Normalization strategies for cDNA microarrays

2000 • 342 citations

Thyroid Hormone Regulation of Hepatic Genes in Vivo Detected by Complementary DNA Microarray

2000 • 332 citations

Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice

1989 • 324 citations

The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin

1999 • 308 citations

Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin

1999 • 276 citations

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

1991 • 268 citations

Anabolic Effects of 1,25-Dihydroxyvitamin D3 on Osteoblasts Are Enhanced by Vascular Endothelial Growth Factor Produced by Osteoblasts and by Growth Factors Produced by Endothelial Cells*

1997 • 229 citations

Antiproliferative Effect of 1α,25-Dihydroxyvitamin D3 in Human Prostate Cancer Cell Line LNCaP Involves Reduction of Cyclin-Dependent Kinase 2 Activity and Persistent G1 Accumulation

1998 • 225 citations

EB1089: A new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro

1992 • 224 citations

Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines.

1991 • 209 citations

1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo.

1999 • 157 citations

Processing and quality control of DNA array hybridization data

2000 • 152 citations

Apoptotic Regression of MCF-7 Xenografts in Nude Mice Treated with the Vitamin D₃Analog, EB1089¹

1998 • 151 citations

Cell Cycle and Hormonal Control of Nuclear-Cytoplasmic Localization of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, in Mammary Tumor Cells

1999 • 129 citations

Increase of vascular endothelial growth factor mRNA expression by 1,25-dihydroxyvitamin D3 in human osteoblast-like cells

1996 • 123 citations

1,25-Dihydroxyvitamin D3 Stimulates Activator Protein-1-dependent Caco-2 Cell Differentiation

1999 • 122 citations

Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines

1997 • 117 citations

Vascular endothelial growth factor expression in head and neck squamous cell carcinoma

1997 • 110 citations

Seocalcitol (EB 1089) A Vitamin D Analogue of Anti-cancer Potential. Background, Design, Synthesis, Pre-clinical and Clinical Evaluation

2000 • 110 citations

Characterisation of the interaction between PCNA and Gadd45.

1995 • 103 citations

Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA.

1995 • 101 citations

Retinoid X Receptor (RXR) Ligands Activate the Human 25-Hydroxyvitamin D3-24-hydroxylase Promoter via RXR Heterodimer Binding to Two Vitamin D-responsive Elements and Elicit Additive Effects with 1,25-Dihydroxyvitamin D3

1997 • 89 citations

Suppression of squamous cell carcinoma growth and differentiation by retinoids.

1994 • 88 citations

A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia

1996 • 81 citations

Action of Low Calcemic 1 ,25-Dihydroxyvitamin D3 Analogue EB1089 in Head and Neck Squamous Cell Carcinoma

2001 • 77 citations

Toward Therapeutic Intervention of Cancer by Vitamin D Compounds

1997 • 64 citations

Recent advances in head and neck cancer--larynx preservation and cancer chemoprevention: the Seventeenth Annual Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 62 citations

Highly potent transcriptional activation by 16-ene derivatives of 1,25-dihydroxyvitamin D3. Lack of modulation by 9-cis-retinoic acid of response to 1,25-dihydroxyvitamin D3 or its derivatives.

1994 • 61 citations

Inappropriate retinoic acid receptor-beta expression in oral dysplasias: correlation with acquisition of the immortal phenotype.

1997 • 55 citations

Implication of retinoic acid receptor gamma in squamous differentiation and response to retinoic acid in head and neck SqCC/Y1 squamous carcinoma cells.

1996 • 45 citations

1α,25-Dihydroxyvitamin D3 Induced Differentiation of Cultured Human Keratinocytes is Accompanied by a PKC-Independent Regulation of AP-1 DNA Binding Activity

2000 • 42 citations

Squamous Carcinoma Cell Lines Fail to Respond to 1,25-Dihydroxyvitamin D Despite Normal Levels of the Vitamin D Receptor

1996 • 39 citations

1α,25-Dehydroxyvitamin D3 Synergism toward Transforming Growth Factor-β1-induced AP-1 Transcriptional Activity in Mouse Osteoblastic Cells via Its Nuclear Receptor

1998 • 35 citations

Stimulation of calmodulin synthesis in proliferating myoblasts by 1,25-dihydroxy-vitamin D3

1990 • 28 citations

Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers.

1997 • 27 citations

Retinoic acid receptor beta induces terminal differentiation of squamous cell carcinoma lines in the absence of cyclin-dependent kinase inhibitor expression.

1998 • 24 citations

Differential Regulation of Vitamin D Responsive Elements in Normal and Transformed Keratinocytes

1998 • 24 citations