Toward Therapeutic Intervention of Cancer by Vitamin D Compounds

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

1996 • 922 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Molecular pharmacology

1994 • 813 citations

Two nuclear signalling pathways for vitamin D

1993 • 559 citations

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells.

1994 • 489 citations

Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors

1992 • 477 citations

1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes.

1987 • 323 citations

20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

1991 • 320 citations

Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.

1996 • 300 citations

Immunomodulatory actions of 1,25-Dihydroxyvitamin D3

1995 • 244 citations

Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

1984 • 236 citations

1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D ₃ in the Intestine

1971 • 216 citations

Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.

1995 • 203 citations

Distinct Conformational Changes Induced by 20-epi Analogues of 1α,25-Dihydroxyvitamin D3 Are Associated with Enhanced Activation of the Vitamin D Receptor

1995 • 201 citations

20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.

1995 • 188 citations

1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.

1990 • 167 citations

Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens

1994 • 150 citations

Induction of apoptosis by beta-lapachone in human prostate cancer cells.

1995 • 142 citations

1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531), a new deltanoid (vitamin D analogue) for prevention of breast cancer in the rat.

1994 • 140 citations

Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.

1993 • 132 citations

Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3.

1994 • 127 citations

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

1996 • 118 citations

Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen-responsive growth of human breast cancer cells

1994 • 116 citations

Granulocyte-macrophage colony-stimulating factor. Sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes.

1987 • 114 citations

Prevention of Preneoplastic Mammary Lesion Development by a Novel Vitamin D Analogue, 1 -Hydroxyvitamin D5

1997 • 104 citations

Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.

1990 • 99 citations

Conformational change and enhanced stabilization of the vitamin D receptor by the 1,25-dihydroxyvitamin D3 analog KH1060.

1996 • 96 citations

Induction of glioma cell death by 1,25 (OH)₂ vitamin D₃: Towards an endocrine therapy of brain tumors?

1994 • 92 citations

The role of vitamin D in normal prostate growth and differentiation.

1996 • 90 citations

A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia

1996 • 81 citations

1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis.

1995 • 77 citations

Increased biological activity of 20-EPI-1,25-dihydroxyvitamin D3 is due to reduced catabolism and altered protein binding

1994 • 74 citations

Novel regulatory actions of 1α,25‐dihydroxyvitamin D₃ on the metabolism of polyphosphoinositides in murine epidermal keratinocytes

1987 • 74 citations

Vitamin D3 analogs: Effect on leukemic clonal growth and differentiation, and on serum calcium levels

1995 • 72 citations

1,25‐dihydroxy‐vitamin‐D₃ enhances antiproliferative effect and transcription of TGF‐β1 on human keratinocytes in culture

1992 • 68 citations

Differentiation of Cultured Human Melanoma Cells Induced by the Aromatic Fatty Acids Phenylacetate and Phenylbutyrate

1994 • 65 citations

1,25(OH)2-16ENE-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia

1994 • 61 citations

1,25-Dihydroxy-24-OXO-16ene-vitamin D3, a renal metabolite of the vitamin D analog 1,25-dihydroxy-16ene-vitamin D3, exerts immunosuppressive activity equal to its parent without causing hypercalcemia in vivo.

1994 • 60 citations

1 alpha,25-Dihydroxy-20-epi-vitamin D3: an extraordinarily potent inhibitor of leukemic cell growth in vitro

1994 • 60 citations

1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally.

1988 • 58 citations

Growth Inhibition of Human Keratinocytes by 1,25-Dihydroxyvitamin D3 Is Linked to Dephosphorylation of Retinoblastoma Gene Product

1993 • 58 citations

Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells.

1995 • 56 citations

1α,25-dihydroxy-24-oxo-16-ene vitamin D3, a metabolite of a synthetic vitamin D3 analog, 1α,25-dihydroxy-16-ene vitamin D3, is equipotent to its parent in modulating growth and differentiation of human leukemic cells

1996 • 34 citations

Growth Regulation and Cellular Changes during Differentiation of Human Prostatic Cancer LNCaP Cells as Induced by T Lymphocyte-Conditioned Medium

1995 • 31 citations

Effects of vitamin D-binding proteins on HL-60 cell differentiation induced by 26,26,26,27,27,27-hexafluoro-1α, 25-dihydroxyvitamin D3

1992 • 19 citations

1,25-Dihydroxy-24-OXO-16ene-vitamin D3, a renal metabolite of the vitamin D analog 1,25-dihydroxy-16ene-vitamin D3, exerts immunosuppressive activity equal to its parent without causing hypercalcemia in vivo

1994 • 19 citations

Oral Calcium Tolerance Test in Extensive Psoriasis Treated with Topical Calcipotriol

1995 • 13 citations

Growth Attenuation in a Human Prostate Cell Line Mediated by a Phorbol Ester

1995 • 12 citations

GROWTH INHIBITION OF HUMAN KERATINOCYTES BY 1,25-DIHYDROXYVITAMIN D3 IS LINKED TO DEPHOSPHORYLATION OF RETINOBLASTOMA GENE PRODUCT

1994 • 2 citations