Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers.

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Head and Neck Cancer

1993 • 2,263 citations

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

1925 • 1,630 citations

Cancer statistics, 1995

1995 • 1,434 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

1991 • 856 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Cellular Biology and Biochemistry of the Retinoids

1984 • 730 citations

The retinoid receptors.

1994 • 665 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

Suppression of Retinoic Acid Receptor–β in Premalignant Oral Lesions and Its Up-Regulation by Isotretinoin

1995 • 419 citations

Comparison of Low-Dose Isotretinoin with Beta Carotene to Prevent Oral Carcinogenesis

1993 • 402 citations

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

1991 • 390 citations

Chemoprevention of cancer with retinoids

1981 • 367 citations

Adjuvant treatment of stage I lung cancer with high-dose vitamin A.

1993 • 353 citations

Patterns of Absolute Risk of Lung Cancer Mortality in Former Smokers

1993 • 316 citations

Smoking-Attributable Cancer Mortality in 1991: Is Lung Cancer Now the Leading Cause of Death Among Smokers in the United States?

1991 • 304 citations

Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells.

1993 • 282 citations

Changes in Bronchial Epithelium in Relation to Cigarette Smoking, 1955–1960 vs. 1970–1977

1979 • 262 citations

Cancer chemoprevention.

1994 • 254 citations

Differential expression of nuclear retinoid receptors in normal, premalignant, and malignant head and neck tissues.

1994 • 218 citations

High frequency of retinoic acid receptor beta abnormalities in human lung cancer.

1991 • 216 citations

Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines.

1991 • 209 citations

Field cancerization in the aerodigestive tract--its etiology, manifestation, and significance.

1984 • 157 citations

Human lung cancer cell lines exhibit resistance to retinoic acid treatment.

1993 • 126 citations

Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.

1992 • 122 citations

A specific defect in the retinoic acid response associated with human lung cancer cell lines.

1994 • 116 citations

Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells

1991 • 114 citations

Inhibition of hamster buccal pouch carcinogenesis by 13-cis-retinoic acid

1980 • 105 citations

Effect of retinoid status on α, β and γ retinoic acid receptor mRNA levels in various rat tissues

1992 • 105 citations

Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines.

1994 • 88 citations

Inhibition of growth and squamous‐cell differentiation markers in cultured human head and neck squamous carcinoma cells by β‐all‐trans retinoic acid

1990 • 85 citations

Implication of RARB in Epidermoid (Squamous) Lung Cancer

1991 • 83 citations

Expression of Retinoic Acid Nuclear Receptors and Tissue Transglutaminase Is Altered in Various Tissues of Rats Fed a Vitamin A-Deficient Diet

1992 • 76 citations

Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells

1991 • 68 citations

Modulation by Retinoids of mRNA Levels for Nuclear Retinoic Acid Receptors in Murine Melanoma Cells

1990 • 61 citations

Vertebrate receptors: molecular biology, dimerization and response elements

1994 • 59 citations

Effects of Vitamin A Deficiency and Hypervitaminosis A in Animals

1954 • 58 citations

Anti-retinoic acid (RA) antibody binding to human premalignant oral lesions, which occurs less frequently than binding to normal tissue, increases after 13-cis-RA treatment in vivo and is related to RA receptor beta expression.

1995 • 55 citations

Inhibition of tumor cell growth by retinoids

1990 • 47 citations

Differential effects of retinoic acid on the in vitro growth and cell‐surface glycoconjugates of 2 human head and neck squamous‐cell carcinomas

1987 • 39 citations

Detection of Nuclear Retinoic Acid Receptor mRNA in Histological Tissue Sections Using Nonradioactive In Situ Hybridization Histochemistry

1994 • 38 citations

Squamous cell differentiation markers in normal, premalignant, and malignant epithelium: Effects of retinoids

1993 • 32 citations

96. Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines

1992 • 26 citations

Retinoic acid suppression of squamous differentiation in human head-and-neck squamous carcinoma cells

1991 • 26 citations

Suppression by retinoic acid of epidermal growth factor receptor autophosphorylation and glycosylation in cultured human head and neck squamous carcinoma cells.

1992 • 19 citations

Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States?

1992 • 17 citations

Retinoid Inhibition of Experimental Carcinogenesis

2018 • 5 citations