The Role for Interleukin‐12 Therapy of Cutaneous T Cell Lymphoma

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Detection of Clonal T-Cell Receptor γ Gene Rearrangements in Early Mycosis Fungoides/Sezary Syndrome by Polymerase Chain Reaction and Denaturing Gradient Gel Electrophoresis (PCR/DGGE)

1994 • 360 citations

Mycosis fungoides and Sezary syndrome [see comments]

1996 • 284 citations

Aberrant Cytokine Production By Sezary Syndrome Patients: Cytokine Secretion Pattern Resembles Murine Th2 Cells

1992 • 252 citations

Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4

2000 • 206 citations

CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides

1995 • 181 citations

Sezary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain)

1996 • 172 citations

Antitumor activity of DAB389 IL-2 fusion toxin in mycosis fungoides

1998 • 139 citations

Progression of Mycosis Fungoides Is Associated with Increasing Cutaneous Expression of Interleukin-10 mRNA

1996 • 135 citations

Mycosis fungoides and the Sézary syndrome: Pathology, staging, and treatment

1990 • 130 citations

IL-12 reverses cytokine and immune abnormalities in Sezary syndrome.

1995 • 129 citations

Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors.

1994 • 111 citations

Detection of Clonal T-Cell Receptor Gene Rearrangements in the Peripheral Blood of Patients with Mycosis Fungoides/Sezary Syndrome

1989 • 104 citations

Mycosis fungoides skin lesions contain CD8⁺ tumor‐infiltrating lymphocytes expressing an activated, MHC‐restricted cytotoxic T‐lymphocyte phenotype

1994 • 65 citations

High-Dose Recombinant Interleukin-2 in Advanced Cutaneous T-Cell Lymphoma

1995 • 61 citations

Large-cell transformation following detection of minimal residual disease in cutaneous T-cell lymphoma: molecular and in situ analysis of a single neoplastic T-cell clone expressing the identical T-cell receptor.

1995 • 55 citations

Depressed Lymphokine Activated Killer Cell Activity in Mycosis Fungoides

1990 • 31 citations

Use of biological response modifiers in the treatment of cutaneous T-cell lymphoma

1998 • 20 citations

Immunopathogenesis of cutaneous T-cell lymphomas

2003 • 15 citations

High-dose recombinant interleukin-2 in advanced cutaneous T-cell lymphoma

1995 • 14 citations