Cognitive reserve and the neurobiology of cognitive aging

The processing-speed theory of adult age differences in cognition.

1996 • 5,100 citations

Mammalian Neural Stem Cells

2000 • 4,689 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline

2003 • 2,195 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex

2002 • 1,906 citations

Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease

2002 • 1,297 citations

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales

2001 • 1,288 citations

Neurogenesis in the Neocortex of Adult Primates

1999 • 1,268 citations

LIFESPAN PSYCHOLOGY: Theory and Application to Intellectual Functioning

1999 • 1,198 citations

Attention and executive deficits in Alzheimer's disease: A critical review

1999 • 1,110 citations

In-vivo measurement of activated microglia in dementia

2001 • 1,025 citations

Longitudinal Research in the Study of Behavior and Development

1979 • 1,018 citations

Executive Functioning as a Potential Mediator of Age-Related Cognitive Decline in Normal Adults.

2003 • 992 citations

The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education

1990 • 977 citations

Influence of leisure activity on the incidence of Alzheimer’s Disease

2001 • 793 citations

Individual differences in rates of change in cognitive abilities of older persons.

2002 • 774 citations

Rates and risk factors for dementia and Alzheimer’s disease

1999 • 757 citations

Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume

2003 • 712 citations

Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease

2001 • 706 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease-Reply

1997 • 704 citations

Inflammatory markers and cognition in well-functioning African-American and white elders

2003 • 686 citations

Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study

2002 • 679 citations

Alzheimer's disease as a disconnection syndrome?

2003 • 653 citations

Neuropathology of Cognitively Normal Elderly

2003 • 630 citations

Cytokines and Cognition—The Case for A Head‐to‐Toe Inflammatory Paradigm

2002 • 608 citations

Emerging Risk Factors for Atherosclerotic Vascular Disease

2003 • 554 citations

Education modifies the relation of AD pathology to level of cognitive function in older persons

2003 • 539 citations

Age, executive function and social decision making: A dorsolateral prefrontal theory of cognitive aging.

2002 • 534 citations

Pathologic Correlates of Nondemented Aging, Mild Cognitive Impairment, and Early-Stage Alzheimer's Disease

2001 • 521 citations

Alzheimer Neuropathologic Alterations in Aged Cognitively Normal Subjects

1999 • 518 citations

Rate of memory decline in AD is related to education and occupation

1999 • 515 citations

Interleukin-6 and risk of cognitive decline

2002 • 510 citations

The Stability of Individual Differences in Mental Ability from Childhood to Old Age: Follow-up of the 1932 Scottish Mental Survey

2000 • 505 citations

Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images

2001 • 456 citations

Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior

2002 • 436 citations

Imaging cerebral atrophy: normal ageing to Alzheimer's disease

2004 • 407 citations

Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study

2002 • 396 citations

The Concept of Cognitive Reserve: A Catalyst for Research

2003 • 389 citations

Looking down on human intelligence.

1997 • 369 citations

“Preclinical” AD revisited

2000 • 368 citations

Relation of Education and Occupation-based Socioeconomic Status to Incident Alzheimer's Disease

2004 • 363 citations

What needs to be explained to account for age-related effects on multiple cognitive variables?

2003 • 356 citations

Lifetime Antecedents of Cognitive Reserve

2003 • 354 citations

Memory impaired aged rats: No loss of principal hippocampal and subicular neurons

1996 • 347 citations

Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants

2002 • 342 citations

Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis

1997 • 323 citations

Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD

2000 • 320 citations

Inflammatory factors are elevated in brain microvessels in Alzheimer's disease

2001 • 286 citations

Looking Down on Human Intelligence

2000 • 281 citations

Premorbid Intellectual Functioning, Education, and Brain Size in Traumatic Brain Injury: An Investigation of the Cognitive Reserve Hypothesis

2003 • 279 citations

Childhood mental ability and dementia

2000 • 277 citations

Does active leisure protect cognition? Evidence from a national birth cohort

2003 • 270 citations

What provides cerebral reserve?

2004 • 267 citations

Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise

1998 • 267 citations

The Effect of Education on Cognitive Performances and Its Implication for the Constitution of the Cognitive Reserve

2003 • 255 citations

Does Participation in Leisure Activities Lead to Reduced Risk of Alzheimer's Disease? A Prospective Study of Swedish Twins

2003 • 246 citations

The Memory Deficits in Alzheimer-Type Dementia: A Review

1986 • 240 citations

Early Life Physical Activity and Cognition at Old Age

2003 • 236 citations

A critical discussion of the role of neuroimaging in mild cognitive impairment*

2003 • 211 citations

Microvascular plasticity in aging

2003 • 208 citations

Cortical Microinfarcts and Demyelination Significantly Affect Cognition in Brain Aging

2004 • 198 citations

Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study

2004 • 172 citations

Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts

1997 • 171 citations

Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder

1994 • 170 citations

Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

2001 • 169 citations

Terminal decline in cognitive function

2003 • 154 citations

The Oregon Brain Aging Study

2000 • 153 citations

Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly

2001 • 153 citations

Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain

1998 • 126 citations

Clinical validity of Braak neuropathological staging in the oldest-old

2000 • 126 citations

C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease

1997 • 126 citations

Distinguishing Between Neurodegenerative Disease and Disease-Free Aging: Correlating Neuropsychological Evaluations and Neuropathological Studies in Centenarians

2002 • 113 citations

Long-term effects of breast-feeding in a national birth cohort: educational attainment and midlife cognitive function

2002 • 106 citations

Smoking, drinking, and other life style factors and cognitive function in men in the Caerphilly cohort

1999 • 105 citations

Decline across different domains of cognitive function in normal ageing: results of a longitudinal population‐based study using CAMCOG

2000 • 97 citations

Interaction of atherosclerosis and inflammation in elderly subjects with poor cognitive function

2003 • 66 citations

Cognitive Reserve–Mediated Modulation of Positron Emission Tomographic Activations During Memory Tasks in Alzheimer Disease

2004 • 59 citations

Neural stem cells in aging and disease

2002 • 55 citations

Genetic Epidemiologic Studies on Age-specified Traits

2000 • 44 citations

Do clever brains age more slowly? Further exploration of a nun result

2003 • 44 citations

Changes in cortical circuits during aging

2003 • 14 citations