A critical discussion of the role of neuroimaging in mild cognitive impairment*
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Abstract
References (151)
Neuropathological stageing of Alzheimer-related changes
1991 • 14,533 citations
Whole Brain Segmentation
2002 • 8,116 citations
A New Clinical Scale for the Staging of Dementia
1982 • 6,699 citations
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
1991 • 4,120 citations
CAMDEX: A Standardised Instrument for the Diagnosis of Mental Disorder in the Elderly with Special Reference to the Early Detection of Dementia
1986 • 2,094 citations
Practice parameter: Management of dementia (an evidence-based review) [RETIRED]
2001 • 1,742 citations
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
1996 • 1,734 citations
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
1997 • 1,680 citations
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study
2001 • 1,567 citations
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
1999 • 1,384 citations
Medical Image Computing and Computer-Assisted Intervention
2009 • 1,322 citations
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
1996 • 1,320 citations
Practice parameter: Diagnosis of dementia (an evidence-based review)
2001 • 1,285 citations
Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
1988 • 1,186 citations
Energy on Demand
1999 • 1,162 citations
Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease
1997 • 1,067 citations
Cerebral white matter lesions, vascular risk factors, and cognitive function in a population‐based study
1994 • 997 citations
A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET.
1995 • 978 citations
Positron Emission Tomography in Evaluation of Dementia
2001 • 882 citations
Localization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Brains of Living Patients With Alzheimer Disease
2002 • 761 citations
Apolipoprotein E Status as a Predictor of the Development of Alzheimer's Disease in Memory-Impaired Individuals
1995 • 747 citations
Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI
2002 • 727 citations
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
2001 • 706 citations
In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease
2001 • 664 citations
Aging-Associated Cognitive Decline
1994 • 649 citations
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
2000 • 642 citations
Presymptomatic hippocampal atrophy in Alzheimer's disease
1996 • 630 citations
Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- <scp>d</scp> -glucose/positron-emission tomography (FDG/PET)
2001 • 619 citations
Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases
2000 • 607 citations
Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
2002 • 574 citations
MRI measures of entorhinal cortex vs hippocampus in preclinical AD
2002 • 565 citations
Hippocampal formation glucose metabolism and volume losses in MCI and AD
2001 • 555 citations
Preclinical prediction of AD using neuropsychological tests
2001 • 519 citations
Preclinical prediction of Alzheimer's disease using SPECT
1998 • 476 citations
MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease ☆ ☆This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health.
2001 • 472 citations
Regional metabolic patterns in mild cognitive impairment and Alzheimer’s disease
2000 • 461 citations
Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
2001 • 456 citations
Discrimination of Alzheimer's disease and mild cognitive impairment by equivalent EEG sources: a cross-sectional and longitudinal study
2000 • 445 citations
Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia
1996 • 438 citations
Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer’s disease
2000 • 435 citations
Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease
1997 • 412 citations
Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia
1997 • 403 citations
Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study
2002 • 396 citations
Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease
2000 • 396 citations
Global Deterioration Scale (GDS) 1982
2004 • 383 citations
Temporal Lobe Regions on Magnetic Resonance Imaging Identify Patients With Early Alzheimer's Disease
1993 • 376 citations
Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT.
2000 • 370 citations
Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment
2002 • 363 citations
Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion
2002 • 358 citations
Using Serial Registered Brain Magnetic Resonance Imaging to Measure Disease Progression in Alzheimer Disease
2000 • 353 citations
Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type
1988 • 352 citations
Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer’s disease☆
2000 • 346 citations
Independent Predictors of Cognitive Decline in Healthy Elderly Persons
2002 • 344 citations
Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD
2000 • 320 citations
Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment
1999 • 315 citations
The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation.
1993 • 314 citations
Longitudinal Study of Cerebral Metabolic Asymmetries and Associated Neuropsychological Patterns in Early Dementia of the Alzheimer Type
1990 • 305 citations
Mild Cognitive Impairment and Alzheimer Disease: Regional Diffusivity of Water
2001 • 304 citations
Beyond the hippocampus
2001 • 301 citations
Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
2001 • 292 citations
Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria
1995 • 281 citations
Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: Correlation with memory functions
1995 • 280 citations
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease
1999 • 274 citations
Cerebrovascular and Brain Morphologic Correlates of Mild Cognitive Impairment in the National Heart, Lung, and Blood Institute Twin Study
2001 • 273 citations
MRI of the Hippocampus in Alzheimer’s Disease: Sensitivity, Specificity, and Analysis of the Incorrectly Classified Subjects
1998 • 271 citations
Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age‐associated memory impairment
1994 • 266 citations
Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography
1992 • 254 citations
Research advances in Alzheimer's disease and related disorders
1995 • 230 citations
Quantitative Electroencephalography Power and Coherence in Alzheimer's Disease and Mild Cognitive Impairment
1996 • 228 citations
Volumetric MRI predicts rate of cognitive decline related to AD and cerebrovascular disease
2002 • 223 citations
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
2002 • 219 citations
Rates of global and regional cerebral atrophy in AD and frontotemporal dementia
2001 • 214 citations
Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease.
1999 • 212 citations
Volumes of Medial Temporal Lobe Structures in Patients with Alzheimer’s Disease and Mild Cognitive Impairment (and in Healthy Controls)
1998 • 210 citations
Cerebral structure on MRI, part II: Specific changes in Alzheimer's and Huntington's diseases
1991 • 201 citations
Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression—A longitudinal evaluation
1997 • 196 citations
Relationships between Regional Neuronal Loss and Neurofibrillary Changes in the Hippocampal Formation and Duration and Severity of Alzheimer Disease
1997 • 195 citations
Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia
2001 • 185 citations
Three-dimensional texture analysis of MRI brain datasets
2001 • 185 citations
Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer’s disease: a morphometric MRI study
2000 • 179 citations
Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease
2000 • 170 citations
Mild cognitive impairment with subcortical vascular features
2002 • 166 citations
Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer's disease.
2002 • 157 citations
Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer's disease.
1992 • 157 citations
Volumetric MRI Measurements Can Differentiate Alzheimer's Disease, Mild Cognitive Impairment, and Normal Aging
2002 • 156 citations
Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly
2001 • 153 citations
Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease
2002 • 142 citations
What is mild cognitive impairment? Variations in definitions and evolution of nondemented persons with cognitive impairment
2003 • 142 citations
1H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging
2001 • 137 citations
Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia
2002 • 136 citations
Impairment of Neocortical Metabolism Predicts Progression in Alzheimer’s Disease
1999 • 131 citations
Abnormal verbal event related potentials in mild cognitive impairment and incipient Alzheimer's disease
2002 • 129 citations
Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits.
2002 • 128 citations
The prognosis of mild cognitive impairment in the elderly
1998 • 126 citations
Do white matter changes contribute to the subsequent development of dementia in patients with mild cognitive impairment? A longitudinal study
2000 • 125 citations
Hippocampus in Alzheimer’s disease: a 3-year follow-up MRI study
2000 • 124 citations
A New Systematic Method of Measurement and Diagnosis of “Mild Cognitive Impairment” and Dementia According to ICD-10 and DSM-III-R Criteria
1992 • 123 citations
Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study.
1997 • 117 citations
1H‐MRS, MRI‐Based Hippocampal Volumetry, and 99mTc‐HMPAO‐SPECT in Normal Aging, Age‐Associated Memory Impairment, and Probable Alzheimer's Disease
1996 • 116 citations
Value of event‐related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease
2002 • 113 citations
Combined Analysis of CSF Tau Levels and [123I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer’s Disease
2002 • 108 citations
Postural Hypotension and EEG Variables Predict Cognitive Decline: Results from a 5-Year Follow-Up of Healthy Elderly Women
1997 • 105 citations
Atrophy of the Corpus Callosum in Alzheimer's Disease Versus Healthy Aging
1996 • 105 citations
Correlation Between Cortical θ Activity and Hippocampal Volumes in Health, Mild Cognitive Impairment, and Mild Dementia
2001 • 102 citations
MR Analysis of the Substantia Innominata in Normal Aging, Alzheimer Disease, and Other Types of Dementia
2002 • 102 citations
Volumetric MRI study of the caudate nucleus in patients with dementia with Lewy bodies, Alzheimer's disease, and vascular dementia
2002 • 100 citations
Medial temporal atrophy and memory impairment in early stage of Alzheimer’s disease: an MRI volumetric and memory assessment study
2000 • 97 citations
Hippocampal Pathology Reflects Memory Deficit and Brain Imaging Measurements in Alzheimers Disease: Clinicopathologic Correlations Using Three Sets of Pathologic Diagnostic Criteria
1996 • 92 citations
Alzheimer's disease : advances in etiology, pathogenesis, and therapeutics
2001 • 89 citations
Hippocampal perfusion in mild Alzheimer's disease
2000 • 86 citations
High-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases.
1995 • 85 citations
Age related cognitive decline: a clinical entity? A longitudinal study of cerebral blood flow and memory performance.
1997 • 82 citations
Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease
1998 • 78 citations
MRI in successful aging, a 5-year follow-up study from the eighth to ninth decade of life
1996 • 77 citations
Presenilin-1–associated abnormalities in regional cerebral perfusion
2001 • 76 citations
Morphometry of the corpus callosum in normal aging and Alzheimer’s disease
1991 • 71 citations
Primary Degenerative Mild Cognitive Impairment: Study Population, Clinical, Brain Imaging and Biochemical Findings
2001 • 69 citations
Theta-power Differences in Patients with Mild Cognitive Impairment Under Rest Condition and During Haptic Tasks
2002 • 67 citations
Examination of the validity of the hierarchical model of neuropathological staging in normal aging and Alzheimer's disease
1998 • 66 citations
Lack of prognostic significance of SPECT abnormalities in non-demented elderly subjects with memory loss.
1999 • 64 citations
Cognitive decline in AD and mild cognitive impairment is associated with global brain damage
2002 • 61 citations
Brain metabolism in Alzheimer's dementia: studies of 11C-deoxyglucose accumulation, CSF monoamine metabolites and neuropsychological test performance in patients and healthy subjects.
1991 • 61 citations
The Diagnostic Value of Magnetic Resonance Imaging and Technetium 99m-HMPAO Single-Photon-Emission Computed Tomography for the Diagnosis of Alzheimer Disease in a Community-Dwelling Elderly Population
1997 • 60 citations
Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men
2002 • 60 citations
Regional magnetization transfer ratio changes in mild cognitive impairment
2001 • 60 citations
Brain electrical activity (quantitative EEG and bit-mapping neurocognitive CNV components), psychometrics and clinical findings in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia
1995 • 59 citations
Early Diagnosis of Alzheimer’s Disease
2000 • 58 citations
MRI of amygdala fails to diagnose early Alzheimerʼs disease
1995 • 53 citations
Morphometry of the corpus callosum in patients with questionable and mild dementia
2002 • 52 citations
Relationship between Clinical and Radiological Diagnostic Criteria for Alzheimer’s Disease and the Extent of Neuropathology as Reflected by ‘Stages’: A Prospective Study
1999 • 51 citations
Five-year retrospective changes in hippocampal atrophy and cognitive screening test performances in very mild Alzheimer's disease: the Tajiri Project
2002 • 41 citations
Age-associated memory impairment and early Alzheimer's disease. Only time will tell the difference.
1995 • 39 citations
MR anatomy of the substantia innominata and findings in Alzheimer disease: a preliminary report.
1995 • 38 citations
Evidence for Atrophy of the Corpus callosum in Alzheimer’s Disease
1994 • 33 citations
Early Diagnosis of Alzheimer Disease With Positron Emission Tomography
2000 • 32 citations
A Follow-Up Study of the Family with the Swedish APP 670/671 Alzheimer’s Disease Mutation
1999 • 31 citations
Treatment of mild cognitive impairment: rationale, present and future strategies
2003 • 30 citations
MRI-guided SPECT measurements of medial temporal lobe blood flow in Alzheimer's disease.
1997 • 29 citations
Positron Emission Tomography in Familial Alzheimer Disease
1995 • 29 citations
SENESCENT MEMORY IMPAIRMENT AND ITS RELATION TO THE GENERAL HEALTH OF THE AGING INDIVIDUAL*
1964 • 26 citations
MR image-based measurement of rates of change in volumes of brain structures. Part I: method and validation
2002 • 24 citations
Segmentation of White Matter Lesions from Volumetric MR Images
1999 • 18 citations
Brain Volumes and Regional Cerebral Blood Flow in Carriers of the Swedish Alzheimer Amyloid Protein Mutation
1998 • 17 citations
PET study in subjects from two Italian FAD families with APP717 Val to Ileu mutation
1997 • 16 citations
Measurements of both hippocampal blood flow and hippocampal gray matter volume in the same individuals with Alzheimerʼs disease
2001 • 14 citations
Hematopoietic Stem Cells: Self-Renewing or Aging?
2002 • 13 citations
MRI-guided SPECT-measurements of medial temporal lobe blood flow in Alzheimer's disease
1997 • 10 citations
Early diagnosis of Alzheimer's disease : focus on quantitative EEG in relation to genetic, biochemical and neuroimaging markers
1999 • 6 citations
MRI and SPECT neuroimaging in mild cognitive impairment and Alzheimer's disease
1997 • 4 citations
P2-222 A comparison of whole-brain activation during face encoding between healthy aging, mild cognitive impairment and Alzheimer's disease
2004 • 1 citations
Deleted Work
1955 • 0 citations