LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

1998 • 991 citations

An autonomous molecular computer for logical control of gene expression

2004 • 817 citations

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

1998 • 724 citations

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

1998 • 659 citations

LNA: a versatile tool for therapeutics and genomics

2003 • 594 citations

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

2000 • 578 citations

Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

1997 • 559 citations

Design of antisense oligonucleotides stabilized by locked nucleic acids

2002 • 528 citations

RNA Interference in Mammalian Cells by Chemically-Modified RNA

2003 • 519 citations

Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

1998 • 334 citations

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA

2003 • 272 citations

NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

2004 • 262 citations

Locked Nucleic Acid (LNA) Recognition of RNA: NMR Solution Structures of LNA:RNA Hybrids

2002 • 251 citations

Structure of a DNA : RNA Hybrid Duplex

1993 • 245 citations

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

1998 • 211 citations

RNA cleaving '10-23' DNAzymes with enhanced stability and activity

2003 • 193 citations

The conformations of locked nucleic acids (LNA)

2000 • 191 citations

Sequence-Dependent Thermodynamic Parameters for Locked Nucleic Acid (LNA)−DNA Duplex Formation

2004 • 188 citations

2′-O,4′-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

2002 • 173 citations

Locked Nucleic Acid: A Potent Nucleic Acid Analog in Therapeutics and Biotechnology

2004 • 173 citations

Triplex-forming oligonucleotide target sequences in the human genome

2004 • 158 citations

Recent improvements in antigene technology

2003 • 154 citations

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

2003 • 153 citations

Real-time genotyping with oligonucleotide probes containing locked nucleic acids

2003 • 150 citations

2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA)

2001 • 143 citations

α-<scp>l</scp>-ribo-Configured Locked Nucleic Acid (α-L-LNA): Synthesis and Properties

2002 • 142 citations

OligoDesign: optimal design of LNA (locked nucleic acid) oligonucleotide capture probes for gene expression profiling

2003 • 126 citations

Design and characterization of decoy oligonucleotides containing locked nucleic acids

2002 • 125 citations

LNAzymes: Incorporation of LNA-Type Monomers into DNAzymes Markedly Increases RNA Cleavage

2002 • 125 citations

Single nucleotide polymorphism genotyping using locked nucleic acid (LNA™)

2003 • 109 citations

c-Jun Regulates Vascular Smooth Muscle Cell Growth and Neointima Formation after Arterial Injury

2002 • 108 citations

NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution Structure of an LNA:RNA Hybrid and Characterization of an LNA:DNA Hybrid

2004 • 104 citations

Detection of the factor V Leiden mutation by direct allele-specific hybridization of PCR amplicons to photoimmobilized locked nucleic acids.

1999 • 96 citations

Implications of High-Affinity Hybridization by Locked Nucleic Acid Oligomers for Inhibition of Human Telomerase

2002 • 92 citations

Functionalized LNA (locked nucleic acid): high-affinity hybridization of oligonucleotides containing N-acylated and N-alkylated 2′-amino-LNA monomers

2003 • 89 citations

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA

2003 • 84 citations

Strong positional preference in the interaction of LNA oligonucleotides with DNA polymerase and proofreading exonuclease activities: implications for genotyping assays

2004 • 75 citations

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

2003 • 72 citations

Sequence and pH Effects of LNA-Containing Triple Helix-Forming Oligonucleotides: Physical Chemistry, Biochemistry, and Modeling Studies^,

2004 • 69 citations

LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E

2002 • 67 citations

Triplex-forming enhancement with high sequence selectivity by single 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA) modification

2000 • 66 citations

FISHing with locked nucleic acids (LNA): evaluation of different LNA/DNA mixmers

2003 • 65 citations

Evaluation of the performance of LNA and MGB probes in 5′-nuclease PCR assays

2003 • 64 citations

Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

2002 • 56 citations

Gaining Target Access for Deoxyribozymes

2004 • 55 citations

Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA

2004 • 54 citations

Locked nucleic acid modified DNA enzymes targeting early growth response-1 inhibit human vascular smooth muscle cell growth

2004 • 54 citations

NMR structure of an -L-LNA:RNA hybrid: structural implications for RNase H recognition

2003 • 53 citations

A Conformationally Constrained Nucleotide Analogue Controls the Folding Topology of a DNA G-Quadruplex

2004 • 52 citations

Direct isolation of poly(A)+ RNA from 4 M guanidine thiocyanate-lysed cell extracts using locked nucleic acid-oligo(T) capture

2004 • 47 citations

Use of locked nucleic acid oligonucleotides to add functionality to plasmid DNA

2003 • 38 citations

Genotyping of the Apolipoprotein B R3500Q Mutation Using Immobilized Locked Nucleic Acid Capture Probes

2002 • 35 citations

A Structure-Activity Study of the Inhibition of HIV-1 Tat-DependentTrans-Activation by Mixmer 2′-O-Methyl Oligoribonucleotides Containing Locked Nucleic Acid (LNA),α-L-LNA, or 2′-Thio-LNA Residues

2003 • 33 citations

Inhibition of ICAM-I gene expression by antisense 2',4'-BNA oligonucleotides

2001 • 19 citations

Antisense Knockdown of PKC-α Using LNA-Oligos

2003 • 14 citations

Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage

2003 • 10 citations