Detection of the factor V Leiden mutation by direct allele-specific hybridization of PCR amplicons to photoimmobilized locked nucleic acids.

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

1994 • 1,065 citations

Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men

1995 • 1,060 citations

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

1995 • 1,036 citations

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

1998 • 991 citations

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

1998 • 724 citations

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

1994 • 446 citations

Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis

1994 • 428 citations

SAMPLE PREPARATION FROM BLOOD, CELLS, AND OTHER FLUIDS

1990 • 427 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

1997 • 236 citations

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

1998 • 211 citations

Microtitration plate enzyme immunoassay to detect PCR-amplified DNA from Candida species in blood

1995 • 158 citations

Disseminated Intravascular Coagulation: Pathophysiological Mechanisms and Manifestations

1998 • 142 citations

Arg⁵⁰⁶–Gln mutation in factor V and risk of thrombosis during pregnancy

1996 • 141 citations

Synthesis of 2‘-Amino-LNA: A Novel Conformationally Restricted High-Affinity Oligonucleotide Analogue with a Handle

1998 • 134 citations

NMR solution structure of a DNA dodecamer containing single G*T mismatches

1998 • 93 citations

Solid‐Phase Synthesis of Oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage

1988 • 88 citations

The incidence of the factor V Leiden mutation in an obstetric population and its relationship to deep vein thrombosis

1997 • 86 citations

Detection of Point Mutations Associated with Resistance of Helicobacter pylori to Clarithromycin by Hybridization in Liquid Phase

1998 • 75 citations

The Arg506Gln Mutation (FV Leiden) Among a Cohort of 4188 Unselected Danish Newborns

1998 • 47 citations

Simple colorimetric microtiter plate hybridization assay for detection of amplified Mycobacterium leprae DNA

1993 • 37 citations

Rapid detection ofSalmonellasubspecies I by PCR combined with non-radioactive hybridisation using covalently immobilised oligonucleotide on a microplate

1995 • 30 citations

Thrombophilia as a multigenic disorder.

1998 • 24 citations

ChemInform Abstract: Synthesis of Novel Bicyclo[2.2.1] Ribonucleosides: 2′‐Amino‐ and 2′‐Thio‐LNA Monomeric Nucleosides.

1999 • 2 citations