Regulated exocytosis: merging ideas on fusing membranes

SNAREs — engines for membrane fusion

2006 • 2,509 citations

THE SYNAPTIC VESICLE CYCLE

2004 • 2,413 citations

Molecular Anatomy of a Trafficking Organelle

2006 • 2,278 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

2000 • 1,397 citations

Bruchpilot Promotes Active Zone Assembly, Ca ²⁺ Channel Clustering, and Vesicle Release

2006 • 767 citations

Clathrin-Mediated Endocytosis Is the Dominant Mechanism of Vesicle Retrieval at Hippocampal Synapses

2006 • 649 citations

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

2002 • 598 citations

The exocytotic event in chromaffin cells revealed by patch amperometry

1997 • 555 citations

How Synaptotagmin Promotes Membrane Fusion

2007 • 536 citations

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

2001 • 501 citations

Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins

2007 • 472 citations

Transport, capture and exocytosis of single synaptic vesicles at active zones

2000 • 464 citations

Three modes of synaptic vesicular recycling revealed by single-vesicle imaging

2003 • 457 citations

Munc18-1 Promotes Large Dense-Core Vesicle Docking

2001 • 392 citations

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23

2003 • 361 citations

A real-time view of life within 100 nm of the plasma membrane

2001 • 352 citations

Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion

1999 • 327 citations

Inhibition of SNARE Complex Assembly Differentially Affects Kinetic Components of Exocytosis

1999 • 319 citations

A Novel Tetanus Neurotoxin-insensitive Vesicle-associated Membrane Protein in SNARE Complexes of the Apical Plasma Membrane of Epithelial Cells

1998 • 308 citations

The v-ATPase V 0 Subunit a1 Is Required for a Late Step in Synaptic Vesicle Exocytosis in Drosophila

2005 • 301 citations

Vesicle trafficking: pleasure and pain from SM genes

2003 • 280 citations

Mechanisms Underlying Phasic and Sustained Secretion in Chromaffin Cells from Mouse Adrenal Slices

1999 • 276 citations

Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release

2006 • 257 citations

The Coupling between Synaptic Vesicles and Ca2+ Channels Determines Fast Neurotransmitter Release

2007 • 256 citations

Vesicular proteins exocytosed and subsequently retrieved by compensatory endocytosis are nonidentical

2006 • 246 citations

v-SNAREs control exocytosis of vesicles from priming to fusion

2005 • 243 citations

Fast vesicle reloading and a large pool sustain high bandwidth transmission at a central synapse

2006 • 230 citations

Interdependence of PKC-Dependent and PKC-Independent Pathways for Presynaptic Plasticity

2007 • 224 citations

Multiple intermediates in SNARE-induced membrane fusion

2006 • 222 citations

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

2001 • 199 citations

Synaptic Vesicles Interchange Their Membrane Proteins with a Large Surface Reservoir during Recycling

2006 • 196 citations

Rab3 Superprimes Synaptic Vesicles for Release: Implications for Short-Term Synaptic Plasticity

2006 • 192 citations

Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

2006 • 181 citations

Dissecting docking and tethering of secretory vesicles at the target membrane

2006 • 179 citations

FUSION PORES AND FUSION MACHINES IN CA²⁺-TRIGGERED EXOCYTOSIS

2006 • 178 citations

UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains

2006 • 173 citations

Reluctant Vesicles Contribute to the Total Readily Releasable Pool in Glutamatergic Hippocampal Neurons

2005 • 163 citations

Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans

2006 • 162 citations

Antagonistic Regulation of Synaptic Vesicle Priming by Tomosyn and UNC-13

2006 • 153 citations

Restriction of Secretory Granule Motion near the Plasma Membrane of Chromaffin Cells

2001 • 151 citations

SNARE-Driven, 25-Millisecond Vesicle Fusion In Vitro

2005 • 148 citations

Distinct Kinetic Changes in Neurotransmitter Release After SNARE Protein Cleavage

2005 • 146 citations

Munc18-Bound Syntaxin Readily Forms SNARE Complexes with Synaptobrevin in Native Plasma Membranes

2006 • 142 citations

Fast vesicle replenishment allows indefatigable signalling at the first auditory synapse

2005 • 136 citations

Docking of Secretory Vesicles Is Syntaxin Dependent

2006 • 127 citations

A Mechanism Intrinsic to the Vesicle Fusion Machinery Determines Fast and Slow Transmitter Release at a Large CNS Synapse

2007 • 125 citations

Bilayers merge even when exocytosis is transient

2004 • 125 citations

Identification of SNAP-47, a Novel Qbc-SNARE with Ubiquitous Expression

2006 • 112 citations

A comparison between exocytic control mechanisms in adrenal chromaffin cells and a glutamatergic synapse

2006 • 110 citations

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses

2006 • 99 citations

Munc18–1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation

2005 • 91 citations

Chromaffin Cell F-actin Disassembly and Potentiation of Catecholamine Release in Response to Protein Kinase C Activation by Phorbol Esters Is Mediated through Myristoylated Alanine-rich C Kinase Substrate Phosphorylation

2001 • 71 citations

The efficiency of the synaptic vesicle cycle at central nervous system synapses

2006 • 71 citations

Molecular Organization and Assembly of the Presynaptic Active Zone of Neurotransmitter Release

2006 • 50 citations

Mso1 Is a Novel Component of the Yeast Exocytic SNARE Complex

2005 • 16 citations

Reduced expression of neuropeptide genes in a genome‐wide screen of a secretion‐deficient mouse

2006 • 11 citations