CAN THE CONTROVERSY OF THE ROLE OF ALUMINUM IN ALZHEIMER'S DISEASE BE RESOLVED? WHAT ARE THE SUGGESTED APPROACHES TO THIS CONTROVERSY AND METHODOLOGICAL ISSUES TO BE CONSIDERED?

Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons

1980 • 995 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Brain Aluminum Distribution in Alzheimer's Disease and Experimental Neurofibrillary Degeneration

1973 • 843 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam

1982 • 678 citations

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION

1965 • 615 citations

Geographical relation between Alzheimer's disease and aluminum in drinking water.

1989 • 600 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study

1992 • 474 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE

1986 • 449 citations

ALUMINIUM POISONING: DIALYSIS ENCEPHALOPATHY, OSTEOMALACIA, AND ANAEMIA

1983 • 370 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION

1965 • 332 citations

Absence of aluminium in neuritic plaque cores in Alzheimer's disease

1992 • 269 citations

Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam.

1984 • 244 citations

Risk for neuropathologically confirmed Alzheimer's disease and residual aluminum in municipal drinking water employing weighted residential histories

1996 • 233 citations

Effect of exposure of miners to aluminium powder

1990 • 232 citations

Aluminum Promotes the Aggregation of Alzheimer′s Amyloid β-Protein in Vitro

1994 • 193 citations

Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging

1981 • 174 citations

Aluminum: A Neurotoxic Product of Acid Rain

1994 • 160 citations

Geographical associations between aluminium in drinking water and death rates with dementia (including Alzheimer's disease), Parkinson's disease and amyotrophic lateral sclerosis in Norway

1990 • 155 citations

Assembly of Alzheimer‐like filaments from full‐length tau protein

1994 • 154 citations

Effect of silicon on gastrointestinal absorption of aluminium

1993 • 140 citations

Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients

1994 • 128 citations

Laser microprobe analysis of brain aluminum in Alzheimer' disease

1993 • 121 citations

Aluminum levels in brain in Alzheimer's disease.

1978 • 121 citations

Neutron activation analysis techniques for identifying elemental status in Alzheimer's disease

1987 • 120 citations

A long-term intravenous model of aluminum maltol toxicity in rabbits: Tissue distribution, hepatic, renal, and neuronal cytoskeletal changes associated with systemic exposure

1989 • 104 citations

Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?

1992 • 98 citations

Failure to find a relationship between mnestic skills of octogenarians and aluminum in drinking water

1991 • 87 citations

A Reexamination of Aluminum in Alzheimer's Disease: Analysis by Energy Dispersive X-ray Microprobe and Flameless Atomic Absorption Spectrophotometry

1989 • 82 citations

Uptake of trace amounts of aluminum into the brain from drinking water.

1995 • 78 citations

Brain aluminum in Alzheimer's disease using an improved GFAAS method.

1992 • 77 citations

Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits

1995 • 73 citations

Aluminium accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure

1992 • 72 citations

Desferrioxamine and Alzheimerʼs Disease

1993 • 71 citations

Regulation of serine protease activity by aluminum: implications for Alzheimer disease.

1993 • 67 citations

Absence of aluminium in Alzheimer's disease brain tissue: Electron microprobe and ion microprobe studie

1991 • 65 citations

Aggregation of tau protein by aluminum

1993 • 57 citations

Aluminum-induced chronic myelopathy in rabbits.

1991 • 57 citations

Concerning the role of aluminum in causing dementia

1995 • 55 citations

Neuronal cytoskeletal lesions induced in the CNS by intraventricular and intravenous aluminium maltol in rabbits

1990 • 53 citations

Studies on Amyotrophic Lateral Sclerosis by Neutron Activation Analysis-2. Comparative Study of Analytical Results on Guam PD, Japanese ALS and Alzheimer Disease Cases

1980 • 52 citations

Aggregation of Amyloid .BETA.-Protein and Its Neurotoxicity: Enhancement by Aluminum and Other Metals.

1994 • 48 citations

Brain destruction alone does not elevate brain aluminum

1981 • 46 citations

Comparison of the effects of elevated intracellular aluminum and calcium levels on neuronal survival and tau immunoreactivity

1993 • 43 citations

Immunochemical cross-reactivity of normal neurofibrils and aluminum-induced neurofibrillary tangles. Immunofluorescence study with antineurofilament serum

1978 • 43 citations

BONE MASS AND DEMENTIA IN HIP FRACTURE PATIENTS FROM AREAS WITH DIFFERENT ALUMINIUM CONCENTRATIONS IN WATER SUPPLIES

1988 • 41 citations

Neurofibrillary neuronal degeneration in dialysis dementia: a feature of aluminum toxicity.

1987 • 39 citations

Quantitative image analysis of temporal changes in tau and neurofilament proteins during the course of acute experimental neurofibrillary degeneration; non-phosphorylated epitopes precede phosphorylation

1996 • 32 citations

Geochemical Risk Factors for Mental Functioning, Based on the Ontario Longitudinal Study of Aging (LSA) II. The Role of pH

1994 • 31 citations

SENILE PLAQUES AND TANGLES IN DIALYSIS DEMENTIA

1981 • 27 citations

Geochemical Risk Factors for Mental Functioning, Based on the Ontario Longitudinal Study of Aging (LSA) I. Results from a Preliminary Investigation

1992 • 26 citations

Partial reversal of aluminium-induced neurofibrillary degeneration by desferrioxamine in adult male rabbits

1994 • 24 citations

Geochemical Risk Factors for Mental Functioning, Based on the Ontario Longitudinal Study of Aging (LSA) V. Comparisons of the Results, relevant to Aluminum Water Concentrations, obtained from the LSA and from Death Certificates mentioning Dementia

1995 • 23 citations

Laser Microprobe Mass Analyzer (LAMMA) — A New Approach to the Study of the Association of Aluminum and Neurofibrillary Tangle Formation

1986 • 21 citations

Vulnerability of the Neuronal Cytoskeleton in Aging and Alzheimer Disease: Widespread Involvement of All Three Major Filament Systems

1991 • 18 citations

Microanalysis of Senile Plaques Using Nuclear Microscopy

1993 • 16 citations

Long-term oral aluminum administration in rabbits. II. Brain and other organs.

1993 • 14 citations