Variants of human tissue-type plasminogen activator. Fibrin binding, fibrinolytic, and fibrinogenolytic characterization of genetic variants lacking the fibronectin finger-like and/or the epidermal growth factor domains.

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

1982 • 486 citations

Fibrinolytic properties of one-chain and two-chain human extrinsic (tissue-type) plasminogen activator.

1982 • 415 citations

A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.

1986 • 314 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Common evolutionary origin of the fibrin‐binding structures of fibronectin and tissue‐type plasminogen activator

1983 • 239 citations

On the interaction of the finger and the kringle-2 domain of tissue-type plasminogen activator with fibrin. Inhibition of kringle-2 binding to fibrin by epsilon-amino caproic acid.

1986 • 239 citations

Cell-surface expression of influenza haemagglutinin from a cloned DNA copy of the RNA gene

1981 • 230 citations

Autonomous functions of structural domains on human tissue-type plasminogen activator.

1986 • 226 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

Assay of Human Tissue-Type Plasminogen Activator (t-PA) with an Enzyme-Linked Immunosorbent Assay (ELISA) Based on Three Murine Monoclonal Antibodies to t-PA

1985 • 213 citations

Inactivation of tissue plasminogen activator in plasma. Demonstration of a complex with a new rapid inhibitor.

1984 • 193 citations

Eukaryotic viral vectors

1982 • 177 citations

Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences

1984 • 176 citations

Involvement of finger domain and kringle 2 domain of tissue-type plasminogen activator in fibrin binding and stimulation of activity by fibrin.

1986 • 155 citations

Measurement of human tissue-type plasminogen activator by a two-site immunoradiometric assay.

1983 • 142 citations

Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins

1984 • 108 citations

Dose-dependent thrombolysis, pharmacokinetics and hemostatic effects of recombinant human tissue-type plasminogen activator for coronary thrombosis

1986 • 71 citations

Purification of human tissue plasminogen activator with Erythrina trypsin inhibitor.

1984 • 70 citations

Folding autonomy of the kringle 4 fragment of human plasminogen.

1983 • 63 citations

In Vitro Fibrinolytic Activity of Recombinant Tissue-Type Plasminogen Activator in the Plasma of Various Primate Species

1984 • 33 citations