SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell Line

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

1993 • 376 citations

Tachykinin receptor types: Classification and membrane signalling mechanisms

1991 • 342 citations

Highly selective agonists for substance P receptor subtypes.

1986 • 316 citations

Multiple tachykinin binding sites in peripheral tissues and in brain

1986 • 276 citations

The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP.

1988 • 245 citations

Selective agonists for substance P and neurokinin receptors

1987 • 239 citations

Receptors for Substance P and Related Neurokinins

1989 • 187 citations

Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus

1983 • 181 citations

Calcium as a modulator of the immediate-early gene cascade in neurons

1988 • 179 citations

Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.

1992 • 175 citations

Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands.

1980 • 168 citations

Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS

1984 • 164 citations

Species differences in affinities of non-peptide antagonists for substance p receptors

1991 • 163 citations

Multiple neurokinin receptors: Recent developments

1988 • 133 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Substance P receptors in primary cultures of cortical astrocytes from the mouse.

1986 • 97 citations

Characterization of a Human NK₁ Tachykinin Receptor in the Astrocytoma Cell Line U 373 MG

1993 • 58 citations

Tachykinin NK₁ receptor subtypes in the rat urinary bladder

1994 • 53 citations

Functional substance P receptors on a human astrocytoma cell line (U-373 MG)

1989 • 51 citations

Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum

1993 • 51 citations

Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK₁ antagonists

1993 • 51 citations

Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells

1988 • 51 citations

Functional characterization of neurokinin‐1 receptors on human U373MG astrocytoma cells

1992 • 50 citations

Non‐peptide antagonists, CP‐96,345 and RP 67580, distinguish species variants in tachykinin NK₁ receptors

1993 • 48 citations

Mammalian tachykinin-induced hydrolysis of inositol phospholipids in rat brain slices

1985 • 44 citations

Characterization of Receptors for Substance P in Human Astrocytoma Cells: Radioligand Binding and Inositol Phosphate Formation

1992 • 42 citations

[Pro9]SP and [pGLU6, PRO9]SP(6–11) interact with two different receptors in the guinea-pig ileum as demonstrated with new SP antagonists

1992 • 38 citations

Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells

1989 • 37 citations

Tachykinin‐Stimulated Inositol Phospholipid Hydrolysis and Taurine Release from Human Astrocytoma Cells

1992 • 23 citations

Effects of tachykinins on [3H]taurine release from human astrocytoma cells (U-373 MG)

1991 • 14 citations

Tachykinins and Phosphatidyl Inositol Turnover in Rat Brain

1987 • 7 citations