Mitogen Activated Protein kinase signal transduction pathways in the prostate.

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

2003 • 3,098 citations

Activation of mitogen-activated protein kinase associated with prostate cancer progression.

1999 • 539 citations

ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)

2004 • 451 citations

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

2001 • 434 citations

Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA

2002 • 405 citations

Effects of Raf Kinase Inhibitor Protein Expression on Suppression of Prostate Cancer Metastasis

2003 • 348 citations

Regulation of prostatic growth and function by peptide growth factors

1996 • 313 citations

Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells

2002 • 301 citations

Rapid signalling by androgen receptor in prostate cancer cells

1999 • 262 citations

Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway

2003 • 242 citations

Prostaglandin E2 Induces Hypoxia-inducible Factor-1α Stabilization and Nuclear Localization in a Human Prostate Cancer Cell Line

2002 • 212 citations

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

2001 • 194 citations

Transforming growth factor-β1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-κB, JNK, and Ras signaling pathways

2003 • 189 citations

Metastasis Suppression: The Evolving Role of Metastasis Suppressor Genes for Regulating Cancer Cell Growth at the Secondary Site

2003 • 187 citations

Interleukin-6- and Cyclic AMP-Mediated Signaling Potentiates Neuroendocrine Differentiation of LNCaP Prostate Tumor Cells

2001 • 183 citations

Identification of a novel Bcl‐xL phosphorylation site regulating the sensitivity of taxol‐ or 2‐methoxyestradiol‐induced apoptosis

2003 • 173 citations

Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells.

2002 • 167 citations

Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.

2001 • 165 citations

Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells

2003 • 163 citations

Phenethyl isothiocyanate-induced apoptosis in p53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases.

2002 • 161 citations

Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.

1999 • 159 citations

Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis.

1997 • 157 citations

Resveratrol Induced Serine Phosphorylation Of p53 Causes Apoptosis In A Mutant p53 Prostate Cancer Cell Line

2002 • 149 citations

Epidermal Growth Factor and Ionizing Radiation Up-regulate the DNA Repair GenesXRCC1andERCC1in DU145 and LNCaP Prostate Carcinoma through MAPK Signaling

2003 • 146 citations

Opposing Effects of 15-Lipoxygenase-1 and -2 Metabolites on MAPK Signaling in Prostate

2002 • 145 citations

ErbB kinases and NDF signaling in human prostate cancer cells

1997 • 143 citations

Tomato and Soy Polyphenols Reduce Insulin-Like Growth Factor-I–Stimulated Rat Prostate Cancer Cell Proliferation and Apoptotic Resistance In Vitro via Inhibition of Intracellular Signaling Pathways Involving Tyrosine Kinase

2003 • 141 citations

Anticarcinogenic Effect of a Polyphenolic Fraction Isolated From Grape Seeds in Human Prostate Carcinoma DU145 Cells: Modulation of Mitogenic Signaling and Cell-Cycle Regulators and Induction of G1 Arrest and Apoptosis

2000 • 139 citations

Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis

2003 • 136 citations

Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis

2003 • 136 citations

Monomethyl selenium-specific inhibition of MMP-2 and VEGF expression: Implications for angiogenic switch regulation

2000 • 131 citations

Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth

2002 • 126 citations

Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer

2003 • 126 citations

p38 Signaling-mediated Hypoxia-inducible Factor 1α and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells

2002 • 126 citations

ACTIVATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE IN HUMAN PROSTATE CANCER

1999 • 119 citations

Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer.

2002 • 119 citations

C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.

2003 • 118 citations

Induction of caspase‐mediated apoptosis and cell‐cycle G₁ arrest by selenium metabolite methylselenol

2002 • 111 citations

Down-regulation of Intrinsic P-glycoprotein Expression in Multicellular Prostate Tumor Spheroids by Reactive Oxygen Species

2001 • 109 citations

Role for 18:1 Lysophosphatidic Acid as an Autocrine Mediator in Prostate Cancer Cells

2002 • 108 citations

Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.

2002 • 107 citations

Ionizing Radiation-Induced Mitogen-Activated Protein (MAP) Kinase Activation in DU145 Prostate Carcinoma Cells: MAP Kinase Inhibition Enhances Radiation-Induced Cell Killing and G₂/M-Phase Arrest

2000 • 103 citations

EGF receptor signaling in prostate morphogenesis and tumorigenesis.

1999 • 100 citations

Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth

2002 • 99 citations

Accelerated in Vivo Growth of Prostate Tumors that Up-Regulate Interleukin-6 Is Associated with Reduced Retinoblastoma Protein Expression and Activation of the Mitogen-Activated Protein Kinase Pathway

2003 • 99 citations

Lysophosphatidic acid‐regulated mitogenic ERK signaling in androgen‐insensitive prostate cancer PC‐3 cells

2002 • 94 citations

PSK, a Novel STE20-like Kinase Derived from Prostatic Carcinoma That Activates the c-Jun N-terminal Kinase Mitogen-activated Protein Kinase Pathway and Regulates Actin Cytoskeletal Organization

2000 • 94 citations

Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells

2001 • 89 citations

MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion

2001 • 89 citations

Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.

2000 • 89 citations

Phenylethyl Isothiocyanate Induces Apoptotic Signaling via Suppressing Phosphatase Activity against c-Jun N-terminal Kinase

2002 • 87 citations

Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation.

2002 • 85 citations

Mitogenic action of LPA in prostate

2002 • 83 citations

Mechanisms for 2‐methoxyestradiol‐induced apoptosis of prostate cancer cells

2002 • 83 citations

Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene

2003 • 81 citations

The role of PTEN in the progression and survival of prostate cancer.

2003 • 80 citations

Regulation of proliferation/apoptosis equilibrium by mitogen-activated protein kinases in normal, hyperplastic, and carcinomatous human prostate

2002 • 79 citations

Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: Modulation of mitogenic signaling, FAK, cell‐cycle entry and apoptosis

2001 • 78 citations

c-Jun N-Terminal Kinase Mediates Apoptotic Signaling Induced byN-(4-Hydroxyphenyl)retinamide

1999 • 78 citations

Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells

1999 • 74 citations

Translation Inhibitors Sensitize Prostate Cancer Cells to Apoptosis Induced by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) by Activating c-Jun N-terminal Kinase

2003 • 73 citations

Biomarker analysis demonstrates a hypoxic environment in the castrated rat ventral prostate gland

2001 • 73 citations

Type I collagen-mediated proliferation of PC3 prostate carcinoma cell line: implications for enhanced growth in the bone microenvironment

2001 • 72 citations

MITOGENIC SIGNALING IN ANDROGEN SENSITIVE AND INSENSITIVE PROSTATE CANCER CELL LINES

2000 • 71 citations

Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis.

1999 • 69 citations

Characterization of a Novel Negative Regulator (DOC-2/DAB2) of c-Src in Normal Prostatic Epithelium and Cancer

2003 • 68 citations

Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells

2003 • 68 citations

Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells

2000 • 66 citations

Activation of p90RSK and growth stimulation of multicellular tumor spheroids are dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP

2001 • 65 citations

Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells

2001 • 64 citations

ESSENTIAL ROLE FOR G PROTEINS IN PROSTATE CANCER CELL GROWTH AND SIGNALING

2000 • 63 citations

Vitamin D and prostate cancer

2001 • 63 citations

Increased ErbB-2 Tyrosine Kinase Activity, MAPK Phosphorylation, and Cell Proliferation in the Prostate Cancer Cell Line LNCaP following Treatment by Select Pesticides

2001 • 63 citations

Genetic inactivation of Par4 results in hyperactivation of NF‐κB and impairment of JNK and p38

2003 • 60 citations

BRADYKININ INDUCED MITOGENESIS OF ANDROGEN INDEPENDENT PROSTATE CANCER CELLS

2001 • 59 citations

Mitogen-activated protein kinases and apoptosis in PIN

1998 • 58 citations

Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.

2002 • 57 citations

Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines

2003 • 57 citations

Insulin-Like Growth Factor I Stimulates Telomerase Activity in Prostate Cancer Cells

2003 • 56 citations

Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase

2003 • 55 citations

Targets of c-Jun NH(2)-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression.

2002 • 53 citations

Focal Adhesion Kinase, Rap1, and Transcriptional Induction of Vascular Endothelial Growth Factor

2000 • 53 citations

C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP

2002 • 52 citations

GUANOSINE PHOSPHATE BINDING PROTEIN COUPLED RECEPTORS IN PROSTATE CANCER: A REVIEW

2002 • 49 citations

Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis

2002 • 49 citations

Fibroblast Growth Factor-1 Induced Promatrilysin Expression Through the Activation of Extracellular-regulated Kinases and STAT3

2002 • 48 citations

Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells

2003 • 48 citations

Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-α)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation

2003 • 46 citations

Contributions of mitogen‐activated protein kinase and nuclear factor kappa B to N‐(4‐hydroxyphenyl)retinamide–induced apoptosis in prostate cancer cells

2002 • 46 citations

Activation of c‐Jun‐N‐terminal‐kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers

2003 • 45 citations

Inhibitors of MEK1/2 Interact with UCN-01 to Induce Apoptosis and Reduce Colony Formation in Mammary and Prostate Carcinoma Cells

2002 • 45 citations

Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells

2001 • 43 citations

Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha.

2000 • 43 citations

Phenylacetate inhibits protein isoprenylation and growth of the androgen-independent LNCaP prostate cancer cells transfected with the T24 Ha-ras oncogene.

1996 • 41 citations

Retinoblastoma Protein-mediated Apoptosis After γ-Irradiation

2002 • 40 citations

Mitogen-activated protein kinase pathway is involved in α6 integrin gene expression in androgen-independent prostate cancer cells: role of proximal Sp1 consensus sequence

2001 • 39 citations

Activation of the cholesterol pathway and Ras maturation in response to stress

1999 • 37 citations

Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2.

2001 • 36 citations

The novel antimicrotubule agent cryptophycin 52 (LY355703) induces apoptosis via multiple pathways in human prostate cancer cells.

2002 • 36 citations

Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis

2000 • 33 citations

5(S)-Hydroxy-6,8,11,14-E,Z,Z,Z-eicosatetraenoate stimulates PC3 cell signaling and growth by a receptor-dependent mechanism.

2002 • 33 citations

Pharmocologic Inhibitors of the Mitogen Activated Protein Kinase Cascade Have the Potential to Interact with Ionizing Radiation Exposure to Induce Cell Death in Carcinoma Cells by Multiple Mechanisms

2002 • 31 citations

Mitogen‐activated protein kinase pathway is involved in androgen‐independent PSA gene expression in LNCaP cells

2003 • 29 citations

Chemoprevention of Breast Cancer with Fenretinide

2001 • 28 citations

Phosphorylation of mitogen-activated protein kinase is inhibited by calcitonin in DU145 prostate cancer cells.

2001 • 27 citations

Requirement of c‐jun for testosterone‐induced sensitization to N‐(4‐hydroxyphenyl)retinamide–induced apoptosis

2003 • 26 citations

Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway

2002 • 22 citations

The effect of EGFR-related tyrosine kinase activity inhibition on the growth and invasion mechanisms of prostate carcinoma cell lines

2003 • 19 citations

Pharmacological inhibition of FGF receptor signaling inhibits LNCaP prostate tumor growth, promatrilysin, and PSA expression

2003 • 19 citations

The response of extracellular signal-regulated kinase (ERK) to androgen-induced proliferation in the androgen-sensitive prostate cancer cell line, LNCaP

2003 • 15 citations

The Effect of EGFR-Related Tyrosine Kinase Activity Inhibition on the Growth and Invasion Mechanisms of Prostate Carcinoma Cell Lines

2003 • 14 citations

BRADYKININ INDUCED MITOGENESIS OF ANDROGEN INDEPENDENT PROSTATE CANCER CELLS

2001 • 14 citations

NONANDROGENIC MEDIATORS OF PROSTATIC GROWTH

2001 • 12 citations

Biomarker analysis demonstrates a hypoxic environment in the castrated rat ventral prostate gland

2001 • 11 citations

Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3‐gallate on epigenetic events in human prostate carcinoma DU145 cells

2001 • 10 citations

Signal Transduction-Mediated Regulation of Urokinase Gene Expression in Human Prostate Cancer

2001 • 9 citations

Gene Therapy Approaches to Sensitization of Human Prostate Carcinoma to Cisplatin by Adenoviral Expression of p53 and by Antisense Jun Kinase Oligonucleotide Methods

2003 • 8 citations

[Mechanism of the activation of extracellular signal-regulated kinase (ERK) in prostate cancer cell lines with different metastatic potential].

2001 • 3 citations

Heat shock protein 70 (HSP70) does not prevent the inhibition of cell growth in DU-145 cells treated with TGF-beta1.

2002 • 2 citations