Abnormalities in DNA rearrangements of immunoglobulin gene loci in precursor B cells derived from X-linked agammaglobulinemia patient and a severe combined immunodeficiency patient

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Release of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes

1973 • 960 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Immunoglobulin-Gene Rearrangements as Unique Clonal Markers in Human Lymphoid Neoplasms

1983 • 621 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Simple and rapid fluorimetric method for DNA microassay

1977 • 491 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

1981 • 327 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

B Lymphocyte Precursors in Human Bone Marrow: An Analysis of Normal Individuals and Patients with Antibody-Deficiency States

1978 • 236 citations

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

1987 • 236 citations

Human immunoglobulin D segments encoded in tandem multigenic families

1981 • 219 citations

Regulated progression of a cultured pre-B-cell line to the B-cell stage

1985 • 174 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

Primary immunodeficiency diseases

1983 • 141 citations

Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements

1984 • 105 citations

Pre-B cells: bone marrow persistence in anti-mu-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamide.

1978 • 88 citations

Pre-B Cells: Bone Marrow Persistence in Anti-µ-Suppressed Mice, Conversion to B Lymphocytes, and Recovery after Destruction by Cyclophosphamide

1978 • 64 citations

Early pre-B cells from normal and X-linked agammaglobulinaemia produce Cμ without an attached VH region

1983 • 63 citations

Immunoglobulin heavy chain gene rearrangements in X‐linked agammaglobulinemia

1986 • 53 citations

Five antigens on human T cells detected by mouse monoclonal antibodies.

1984 • 25 citations

Heterogeneity of b lymphocyte differentiation in severe combined immunodeficiency disease.

1980 • 25 citations

Immunology: Exclusive immunoglobulin genes

1984 • 14 citations

Differentiation of precursor T lymphocytes in man and delineation of the selective abnormalities in severe combined immune deficiency disease

1982 • 13 citations

My Uncle Eustace—Maker of Rings (1885–1916)

1977 • 1 citations