ACUTE MYELOID LEUKEMIA: TREATMENTOF ADULTS UNDER 60 YEARS

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,984 citations

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,765 citations

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

1979 • 1,538 citations

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

2001 • 1,531 citations

Intensive Postremission Chemotherapy in Adults with Acute Myeloid Leukemia

1994 • 1,428 citations

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

1996 • 1,158 citations

Antileukemic Effect of Chronic Graft-versus-Host Disease

1981 • 1,112 citations

Efficacy and Safety of Gemtuzumab Ozogamicin in Patients With CD33-Positive Acute Myeloid Leukemia in First Relapse

2001 • 877 citations

Autologous or Allogeneic Bone Marrow Transplantation Compared with Intensive Chemotherapy in Acute Myelogenous Leukemia

1995 • 874 citations

Prognostic Implication of FLT3 and N- RAS Gene Mutations in Acute Myeloid Leukemia

1999 • 773 citations

Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype.

1998 • 699 citations

Chemotherapy Compared with Autologous or Allogeneic Bone Marrow Transplantation in the Management of Acute Myeloid Leukemia in First Remission

1998 • 628 citations

Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia. A Southwest Oncology Group Study

1999 • 596 citations

Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial

1998 • 580 citations

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

2000 • 559 citations

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation

2000 • 525 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

A randomized study of high-dose cytarabine in induction in acute myeloid leukemia [see comments]

1996 • 474 citations

A randomized placebo-controlled phase III study of granulocyte- macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490)

1995 • 462 citations

Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate

1999 • 458 citations

Granulocyte–Macrophage Colony-Stimulating Factor after Initial Chemotherapy for Elderly Patients with Primary Acute Myelogenous Leukemia

1995 • 458 citations

A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial

1999 • 444 citations

A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study

1996 • 423 citations

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

2001 • 421 citations

Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate

1999 • 415 citations

Randomized Trial of Bone Marrow Versus Lenograstim-Primed Blood Cell Allogeneic Transplantation in Patients With Early-Stage Leukemia: A Report From the Société Française de Greffe de Moelle

2000 • 391 citations

Intensified induction and consolidation with or without maintenance chemotherapy for acute myeloid leukemia (AML): two multicenter studies of the German AML Cooperative Group.

1985 • 366 citations

Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: a randomised trial

2000 • 365 citations

A Randomized, Double-Blind, Placebo-Controlled, Phase III Study of Filgrastim in Remission Induction and Consolidation Therapy for Adults With De Novo Acute Myeloid Leukemia

1997 • 334 citations

Comparison of Autologous Bone Marrow Transplantation and Intensive Chemotherapy as Postremission Therapy in Adult Acute Myeloid Leukemia

1997 • 334 citations

Double induction strategy for acute myeloid leukemia: the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group.

1999 • 332 citations

Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)

1997 • 321 citations

A Controlled Study of Recombinant Human Granulocyte Colony-Stimulating Factor in Elderly Patients after Treatment for Acute Myelogenous Leukemia

1995 • 321 citations

Feasibility of Immunotherapy of Relapsed Leukemia With Ex Vivo–Generated Cytotoxic T Lymphocytes Specific for Hematopoietic System-Restricted Minor Histocompatibility Antigens

1999 • 309 citations

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

2000 • 284 citations

Mylotarg? (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation

2001 • 278 citations

Etoposide in acute nonlymphocytic leukemia. Australian Leukemia Study Group

1990 • 276 citations

Clinical significance of cytogenetics in acute myeloid leukemia.

1997 • 267 citations

Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells.

1996 • 259 citations

A phase I trial of monoclonal antibody M195 in acute myelogenous leukemia: specific bone marrow targeting and internalization of radionuclide.

1991 • 231 citations

Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux- cases

1995 • 229 citations

Cytogenetic pattern in acute myelogenous leukemia: a major reproducible determinant of outcome.

1988 • 222 citations

A systematic collaborative overview of randomized trials comparing idarubicin with daunorubicin (or other anthracyclines) as induction therapy for acute myeloid leukaemia

1998 • 161 citations

How to avoid bias when comparing bone marrow transplantation with chemotherapy.

1991 • 161 citations

Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

2000 • 156 citations

TRANSPLANTATION OF UNPURGED AUTOLOGOUS BONE-MARROW IN ACUTE MYELOID LEUKAEMIA IN FIRST REMISSION

1984 • 139 citations

Chemotherapy v marrow transplantation for adults with acute nonlymphocytic leukemia: a five-year follow-up

1988 • 137 citations

Autologous bone marrow transplantation for acute myeloblastic leukemia in Europe: further evidence of the role of marrow purging by mafosfamide. European Co-operative Group for Bone Marrow Transplantation (EBMT).

1991 • 135 citations

Quality of life in patients with acute myelogenous leukemia in prolonged first complete remission after bone marrow transplantation (allogeneic or autologous) or chemotherapy: a cross-sectional study of the EORTC-GIMEMA AML 8A trial

1997 • 133 citations

Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone

1999 • 123 citations

Effect of postremission chemotherapy before human leukocyte antigen–identical sibling transplantation for acute myelogenous leukemia in first complete remission

2000 • 118 citations

Supersaturating infusional humanized anti-CD33 monoclonal antibody HuM195 in myelogenous leukemia.

1998 • 110 citations

Expression of the Lung Resistance Protein Predicts Poor Outcome in De Novo Acute Myeloid Leukemia

1998 • 110 citations

Impact of cytogenetic abnormalities on outcome of bone marrow transplants in acute myelogenous leukemia in first remission.

1995 • 110 citations

Incidence of AML1/ETO fusion transcripts in patients entered into the MRC AML trials

1997 • 107 citations

Comparison of ‘sequential’ versus ‘standard’ chemotherapy as re‐induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): results of the UK Medical Research Council AML‐R trial

2001 • 105 citations

The Highest Leukaemia-Free Survival After Allogeneic Bone Marrow Transplantation is Seen in Patients with Grade I Acute Graft-Versus-Host Disease

1996 • 99 citations

Overexpression of lung‐resistance protein and increased P‐glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival

1998 • 94 citations

The influence of HLA‐matched sibling donor availability on treatment outcome for patients with AML: an analysis of the AML 8A study of the EORTC Leukaemia Cooperative Group and GIMEMA

1998 • 94 citations

Frequency of CBFβ/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials

1997 • 93 citations

Parallel Phase I Studies of Daunorubicin Given With Cytarabine and Etoposide With or Without the Multidrug Resistance Modulator PSC-833 in Previously Untreated Patients 60 Years of Age or Older With Acute Myeloid Leukemia: Results of Cancer and Leukemia Group B Study 9420

1999 • 89 citations

Unrelated donor or autologous marrow transplantation for treatment of acute leukemia

1994 • 74 citations

Autologous marrow transplantation in patients with acute nonlymphocytic leukemia in first remission.

1985 • 69 citations

Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?

1999 • 64 citations

Intensifying Induction Therapy in Acute Myeloid Leukemia: Has a New Standard of Care Emerged?

1997 • 60 citations

Autologous blood cell vs marrow transplantation for acute myeloid leukemia in complete remission: an EBMT retrospective analysis

2000 • 57 citations

Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL

1994 • 55 citations

Reasons That Patients with Acute Myelogenous Leukemia Do Not Undergo Allogeneic Bone Marrow Transplantation

1992 • 50 citations

Intensifying Induction Therapy in Acute Myeloid Leukemia: Has a New Standard of Care Emerged?

1997 • 47 citations

Treatment of Poor Prognosis AML Patients Using PSC833 (Valspodar) Plus Mitoxantrone, Etoposide, and Cytarabine (PSC-MEC)

1999 • 45 citations

HLA-identical sibling bone marrow transplants vs chemotherapy for acute myelogenous leukemia in first remission.

1996 • 44 citations

Expression of multidrug resistance-associated protein (MRP) mRNA in blast cells from acute myeloid leukemia (AML) patients.

1996 • 42 citations

Dose-finding study of valspodar (PSC 833) with daunorubicin and cytarabine to reverse multidrug resistance in elderly patients with previously untreated acute myeloid leukemia

2000 • 28 citations

T-cell depletion in allogeneic bone marrow transplantation: progress and problems.

1989 • 27 citations

Karyotype in acute myeloblastic leukemia: prognostic significance in a prospective study assessing bone marrow transplantation in first remission.

1995 • 25 citations

The Lung Resistance Protein (LRP) Predicts Poor Outcome in Acute Myeloid Leukemia

1999 • 15 citations

The importance of diagnostic cytogenetics in older patients with AML: Analysis of 922 patients entered into the MRC AML 11 trial.

1999 • 5 citations

Use of growth factors during induction therapy for acute myeloid leukemia.

1996 • 3 citations

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