Evidence for multiple steps in neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells following transfection with Harvey murine sarcoma virus oncogene (v-Ha-ras).

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Cellular Oncogenes and Multistep Carcinogenesis

1983 • 1,154 citations

[17] A rapid alkaline extraction method for the isolation of plasmid DNA

1983 • 983 citations

[17] Plasmid cloning vehicles derived from plasmids ColE1, F, R6K, and RK2

1979 • 508 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

1980 • 387 citations

The roles of individual polyoma virus early proteins in oncogenic transformation

1982 • 366 citations

Evidence for the progressive nature of neoplastic transformation in vitro.

1978 • 313 citations

Correlation of in vitro growth properties and tumorigenicity of Syrian hamster cell lines.

1979 • 134 citations

Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection

1984 • 121 citations

Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens

1976 • 120 citations

Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs.

1982 • 109 citations

A preneoplastic stage in the spontaneous neoplastic transformation of syrian hamster embryo cells in culture.

1980 • 70 citations

Multistep origin of tumor-forming ability in Chinese hamster embryo fibroblast cells.

1982 • 51 citations

Expression of human genes for adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase after genetic transformation of mouse cells with purified human DNA

1980 • 49 citations

High frequency of carcinogen-induced early, preneoplastic changes in rat tracheal epithelial cells in culture.

1983 • 40 citations

The murine sarcoma virus (MSV).

1971 • 38 citations

Characteristics of the <italic>In Vitro</italic> Assay of Murine Sarcoma Virus (Moloney) and Virus-Infected Cells

1968 • 31 citations

Clonal analysis of the stepwise appearance of anchorage independence and tumorigenicity in CAK, a permanent line of mouse cells.

1982 • 31 citations

Neoplastic Conversion of Preneoplastic Syrian Hamster Cells: Rate Estimation by Fluctuation Analysis

1983 • 20 citations