Expression of pro‐ and anti‐apoptosis gene products in brains from paediatric patients with HIV‐1 encephalitis

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.

1986 • 1,242 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2.

1994 • 664 citations

Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia

1995 • 663 citations

Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.

1992 • 531 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Neocortical damage during HIV infection

1991 • 456 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

1995 • 386 citations

Loss of neurons in the frontal cortex in AIDS brains

1990 • 355 citations

Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin

1994 • 317 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes

1996 • 316 citations

Pathologic features of AIDS encephalopathy in children: Evidence for LAV/HTLV-III infection of brain

1986 • 300 citations

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA

1995 • 300 citations

Evidence of apoptotic cell death in HIV encephalitis.

1995 • 297 citations

Pathology of HIV-1 Infection of the Central Nervous System. A review

1992 • 244 citations

Neuronal apoptosis in HIV infection in adults

1995 • 244 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Apoptotic neurons in brains from paediatric patients with HIV‐I encephalitis and progressive encephalopathy

1995 • 220 citations

Characterization of translocation contact sites involved in the import of mitochondrial proteins.

1987 • 219 citations

Neurotoxic Effects of Tumor Necrosis Factor Alpha in Primary Human Neuronal Cultures are Mediated by Activation of the Glutamate AMPA Receptor Subtype: Implications for AIDS Neuropathogenesis

1993 • 175 citations

Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon gamma.

1995 • 174 citations

Immunohistochemical analysis of Mcl-1 and Bcl-2 proteins in normal and neoplastic lymph nodes.

1994 • 163 citations

Microglial Turnover in the Injured CNS: Activated Microglia Undergo Delayed DNA Fragmentation Following Peripheral Nerve Injury

1995 • 148 citations

Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.

1994 • 148 citations

Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes.

1991 • 143 citations

A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes.

1995 • 137 citations

Morphometric Comparisons of Optic Nerve Axon Loss in Acquired Immunodeficiency Syndrome

1992 • 113 citations

Mitosis and apoptosis of microgliain vivo induced by an anti-CR3 antibody which crosses the blood-brain barrier

1993 • 78 citations

Activation of nuclear factor kB in brains from children with HIV‐I encephalitis

1995 • 34 citations

Apoptosis in the brain. Physiology and pathology.

1995 • 32 citations

Ultrastructural localization of a fluorinated bile salt in hepatocytes.

1994 • 28 citations

Labelling of cells of the mononuclear phagocyte system in routinely processed archival biopsy specimens with monoclonal antibody EBM/11.

1990 • 20 citations