Cure of metastatic human colonic cancer in mice with radiolabeled monoclonal antibody fragments.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Levamisole and Fluorouracil for Adjuvant Therapy of Resected Colon Carcinoma

1990 • 2,226 citations

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 • 1,851 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Use of Radiolabeled Antibodies to Carcinoembryonic Antigen for the Detection and Localization of Diverse Cancers by External Photoscanning

1978 • 759 citations

Factors influencing the natural history of colorectal liver metastases

1994 • 712 citations

The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03.

1993 • 683 citations

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma

1994 • 647 citations

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

1979 • 638 citations

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

1992 • 563 citations

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

1992 • 397 citations

Clinical perspective of human colorectal cancer metastasis

1984 • 384 citations

Relationships between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides.

1995 • 366 citations

The epithelial cell surface antigen 17–1A, a target for antibody‐mediated tumor therapy: Its biochemical nature, tissue distribution and recognition by different monoclonal antibodies

1986 • 243 citations

Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer

1994 • 242 citations

Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR.

1997 • 224 citations

Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer

1989 • 220 citations

Epithelial tumor cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterization, and prognostic significance.

1990 • 209 citations

Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives.

1995 • 158 citations

Absorbed fractions for electrons and beta particles in spheres of various sizes.

1994 • 131 citations

Phase I/II clinical radioimmunotherapy with an iodine-131-labeled anti-carcinoembryonic antigen murine monoclonal antibody IgG.

1997 • 117 citations

Cancer Therapy with Radiolabeled Antibodies

2018 • 115 citations

GW-39: A NEW HUMAN TUMOR SERIALLY TRANSPLANTABLE IN THE GOLDEN HAMSTER

1966 • 112 citations

Overcoming the nephrotoxicity of radiometal-labeled immunoconjugates: improved cancer therapy administered to a nude mouse model in relation to the internal radiation dosimetry.

1997 • 111 citations

Two new monoclonal antibodies, EPB-1 and EPB-2, reactive with human lymphoma.

1989 • 90 citations

Characterization of second-generation monoclonal antibodies against carcinoembryonic antigen

1993 • 84 citations

Targeted therapy of athymic mice bearing GW-39 human colonic cancer micrometastases with 131I-labeled monoclonal antibodies.

1992 • 75 citations

Experimental studies on the role of antibody fragments in cancer radio-immunotherapy: Influence of radiation dose and dose rate on toxicity and anti-tumor efficacy

1998 • 67 citations

Tumor, red marrow, and organ dosimetry for 131I-labeled anti-carcinoembryonic antigen monoclonal antibody.

1990 • 63 citations

Clinical evaluation of tumor targeting with a high-affinity, anticarcinoembryonic-antigen-specific, murine monoclonal antibody, MN-14

1993 • 59 citations

Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic cancer xenografts.

1994 • 58 citations

Successful Radioimmuno-therapy for Lung Metastasis of Human Colonic Cancer in Nude Mice

1991 • 56 citations

Variables influencing tumor dosimetry in radioimmunotherapy of CEA-expressing cancers with anti-CEA and antimucin monoclonal antibodies.

1997 • 53 citations

Studies on the red marrow dosimetry in radioimmunotherapy: an experimental investigation of factors influencing the radiation-induced myelotoxicity in therapy with beta-, Auger/conversion electron-, or alpha-emitters.

1999 • 34 citations

Dose-rate effects between 0.3 and 30 GY/H in a normal and a malignant human cell line

1994 • 25 citations

Improved experimental cancer therapy by radioantibody dose intensification as a result of syngeneic bone marrow transplantation.

1995 • 25 citations

Clinical experience with leucovorin and 5-fluorouracil

1989 • 24 citations

Dose-rate effect between 1 and 10 Gy/min in mammalian cell culture

1984 • 17 citations

Can occult metastases be Treated by radioimmunotherapy?

1997 • 15 citations

Application of cytokine intervention for improved radio-antibody dose delivery

1997 • 7 citations

Can Preirradiation Enhance Tumor Uptake of Radiolabeled Pharmaceuticals? Experimental Data in a Mouse Neuroblastoma Xenograft System

1996 • 2 citations