Clinical experience with leucovorin and 5-fluorouracil

A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

1987 • 452 citations

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

1981 • 287 citations

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

1978 • 196 citations

Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

1986 • 162 citations

Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects.

1984 • 134 citations

A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.

1985 • 119 citations

Large-Bowel Cancer—The Current Status of Treatment

1976 • 99 citations

Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer.

1988 • 75 citations

Leucovorin plus 5-fluorouracil: an effective treatment for metastatic colon cancer.

1987 • 75 citations

Microbiological analysis of 5-formyltetrahydrofolic acid and other folates using an automatic 96-well plate reader

1986 • 60 citations

Analysis of folate cofactor levels in tissues using high-performance liquid chromatography

1983 • 58 citations

Resolution of the stereoisomers of leucovorin and 5-methyltetrahydrofolate by chiral high-performance liquid chromatography

1988 • 39 citations

5-FU/leucovorin: biochemical modulation that works?

1987 • 28 citations

Distribution and Metabolism of Calcium Leucovorin in Normal and Tumor Tissue

1988 • 18 citations

A Controlled Clinical Trial Including Folinic Acid at Two Distinct Dose Levels in Combination with 5-Fluorouracil (5FU) for the Treatment of Advanced Colorectal Cancer: Experience of the Mayo Clinic and North Central Cancer Treatment Group

1988 • 18 citations

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