Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer

A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma.

1988 • 513 citations

A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

1987 • 452 citations

Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid.

1986 • 402 citations

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

1981 • 287 citations

Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally.

1980 • 249 citations

Applications of dose intensity to problems in chemotherapy of breast and colorectal cancer.

1987 • 236 citations

Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans.

1981 • 211 citations

Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.

1978 • 196 citations

Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

1986 • 162 citations

The enhancement of 5-fluorouracil antimetabolic activity by leucovorin, menadione and α-tocopherol

1982 • 91 citations

5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer: a randomized comparison. A Southwest Oncology Group Study.

1987 • 84 citations

A phase II trial of 5-fluorouracil and high-dose intravenous leucovorin in gastric carcinoma.

1987 • 61 citations

Phase I and pharmacologic studies of intraperitoneal leucovorin and 5-fluorouracil in patients with advanced cancer.

1986 • 31 citations

The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy

1988 • 31 citations

Failure of High-Dose Leucovorin To Improve Therapy With the Maximally Tolerated Dose of 5-Fluorouracil: A Murine Study With Clinical Relevance?

1988 • 30 citations

5-FU/leucovorin: biochemical modulation that works?

1987 • 28 citations

A Randomized Trial of 5-Fluorouracil Alone Versus 5-Fluorouracil and High Dose Leucovorin in Untreated Advanced Colorectal Cancer Patients

1988 • 17 citations

Adjuvant Therapy for Colorectal Cancer: The NSABP Clinical Trials

1988 • 7 citations

A Northern California Oncology Group Randomized Trial of Single Agent 5-FU vs. High-Dose Folinic Acid + 5-FU vs. Methotrexate + 5-FU + Folinic Acid in Patients with Disseminated Measurable Large Bowel Cancer

1988 • 5 citations