The Unique Amino-Terminal Domain of p56^lckRegulates Interactions with Tyrosine Protein Phosphatases in T Lymphocytes

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection

1989 • 692 citations

Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src

1991 • 630 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

The when and how of Src regulation

1993 • 543 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

1992 • 320 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1993 • 283 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1993 • 221 citations

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

1992 • 212 citations

Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts.

1988 • 208 citations

Regulation of Lymphocyte Function by Protein Phosphorylation

1993 • 203 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP.

1993 • 199 citations

Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.

1993 • 179 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines.

1987 • 132 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

CD8+ T-cell clones deficient in the expression of the CD45 protein tyrosine phosphatase have impaired responses to T-cell receptor stimuli.

1991 • 109 citations

A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56^lck and pp³², a possible common substrate

1991 • 104 citations

Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C.

1988 • 103 citations

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

1994 • 92 citations

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

1993 • 90 citations

Phosphorylation of serine 59 of p56lck in activated T cells.

1993 • 85 citations

Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains.

1992 • 82 citations

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.

1992 • 81 citations

Src-related protein tyrosine kinases and T-cell receptor signalling

1992 • 73 citations

The lymphocyte-specific tyrosine protein kinase p56lck.

1991 • 60 citations

CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line.

1993 • 54 citations

Anti-CD3 and phorbol ester induce distinct phosphorylated sites in the SH2 domain of p56lck.

1993 • 54 citations

Insulin‐specific T cell hybridomas derived from (H‐2^b × H‐2^k)F₁ mice preferably employ F₁unique restriction elements for antigen recognition

1985 • 44 citations

The SH2 Domain is Required for Stable Phosphorylation of p56^1ck at Tyrosine 505, the Negative Regulatory Site

1993 • 44 citations

Oncogenic activation of p59fyn tyrosine protein kinase by mutation of its carboxyl-terminal site of tyrosine phosphorylation, tyrosine 528.

1994 • 43 citations

Interactions of the SH2 domain of lymphocyte-specific tyrosine protein kinase p56lck with phosphotyrosine-containing proteins.

1993 • 43 citations

Analysis of the sites in p56lck whose phosphorylation is induced by tetradecanoyl phorbol acetate.

1990 • 35 citations

Use of the Escherichia coli gene for asparagine synthetase as a selective marker in a shuttle vector capable of dominant transfection and amplification in animal cells.

1987 • 33 citations

Intramolecular and extramolecular mechanisms repress the catalytic function of p56lck in resting T-lymphocytes.

1994 • 19 citations