CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose

1970 • 1,349 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes

1977 • 777 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Two subsets of rat T lymphocytes defined with monoclonal antibodies

1980 • 678 citations

Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

1992 • 588 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice

1992 • 424 citations

In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.

1981 • 389 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Susceptibility of β2-microglobulin-deficient mice to Trypanosoma cruzi infection

1992 • 329 citations

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

1991 • 309 citations

MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses

1984 • 305 citations

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

1991 • 287 citations

In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections.

1988 • 256 citations

Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi.

1990 • 238 citations

Lymphocyte activation by HIV-1 envelope glycoprotein

1988 • 224 citations

Substitute for Benzidine in Myeloperoxidase Stains

1975 • 219 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1

1991 • 185 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen.

1986 • 159 citations

Tumour necrosis factors (α, β) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication

1990 • 145 citations

The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones.

1983 • 141 citations

Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

1990 • 136 citations

Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

1990 • 130 citations

Gamma-interferon-like immunoreactivity in axotomized rat motor neurons

1989 • 126 citations

Bidirectional activating signals between Trypanosoma brucei and CD8⁺ T cells: A trypanosome‐released factor triggers interferon‐γ production that stimulates parasite growth

1991 • 114 citations

Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection.

1990 • 110 citations

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 • 107 citations

Identification of an epidermal growth factor receptor homologue in trypanosomes

1989 • 106 citations

In Vivo Treatment of Rats with Monoclonal Anti‐T‐Cell Antibodies

1985 • 97 citations

The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.

1988 • 88 citations

Depletion of CD8+ T cells suppresses growth of Trypanosoma brucei brucei and interferon-gamma) production in infected rats

1990 • 86 citations

Transforming growth factors β1 and β2: cytokines with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell function

1989 • 84 citations

Interferon‐gamma‐like immunoreactivity in certain neurons of the central and peripheral nervous system

1989 • 83 citations

Differential expression and regulation of the human CD8α and CD8β chains

1990 • 79 citations

Monoclonal antibody two-site ELISA for human IFN-γ

1989 • 79 citations

Regulation of Parasitaemia in Mice Infected with Trypanosoma brucei

1985 • 72 citations

Purification, chain separation and sequence of the MRC OX-8 antigen, a marker of rat cytotoxic T lymphocytes.

1985 • 70 citations

Molecular interactions required for triggering alloantigen-specific cytolytic T lymphocytes.

1989 • 68 citations

A Trypanosoma brucei brucei‐Derived Factor that Triggers CD8⁺ Lymphocytes to Interferon‐γ Secretion: Purification, Characterization and Protective Effects In Vivo by Treatment with a Monoclonal Antibody against the Factor

1993 • 67 citations

Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity

1991 • 65 citations

Gamma‐Interferon is Produced by CD3+ and CD3‐ Lymphocytes

1987 • 64 citations

Concomitant production of different lymphokines in activated T cells

1988 • 52 citations

T cell triggering by lectins I. Requirements for interleukin 2 production;er lectin concentration determines the accessory cell dependency

1985 • 50 citations

CD4⁺, CD8⁺, and CD4⁻ CD8⁻ T Cells in CSF and Blood of Patients with Multiple Sclerosis and Tension Headache

1990 • 32 citations

Helper interleukins are produced by both CD4 and CD8 splenic T cells after mitogen stimulation

1991 • 31 citations

T cell recognition of nonpolymorphic determinants on H-2 class I molecules.

1988 • 17 citations

IL-1 as a co-factor for lymphokine-secreting CD8+ murine T cells.

1988 • 16 citations

Interference in general immune function by parasite infections; African trypanosomiasis as a model system

1984 • 16 citations

Bidirectional signals betweenTrypanosoma brucei brucei and dorsal root ganglion neurons

1992 • 13 citations

CD8+ alpha/beta or gamma/delta T cell receptor-bearing T cells from athymic nude mice are cytolytically active in vivo.

1991 • 12 citations