Prediction of secondary structure by evolutionary comparison: Application to the α subunit of tryptophan synthase

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Escherichia coli and Salmonella typhimurium: Cellular and molecular biology

1988 • 3,957 citations

Prediction of protein conformation

1974 • 3,327 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Structural patterns in globular proteins

1976 • 1,286 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Prediction of chain flexibility in proteins

1985 • 1,123 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Crystal Structure of Human Carbonic Anhydrase C

1972 • 446 citations

How good are predictions of protein secondary structure?

1983 • 375 citations

Identification of protein sequence homology by consensus template alignment

1986 • 283 citations

Yeast gene TRP5: structure, function, regulation.

1982 • 245 citations

Turn prediction in proteins using a pattern-matching approach

1986 • 212 citations

Three-dimensional structure of ribulose-1,5-bisphosphate carboxylase/oxygenase from Rhodospirillum rubrum at 2.9 Å resolution

1986 • 171 citations

Tryptophan Synthase: Structure, Function, and Subunit Interaction

1979 • 160 citations

Nucleotide sequences of trpA of Salmonella typhimurium and Escherichia coli: an evolutionary comparison.

1979 • 148 citations

Recognition of super-secondary structure in proteins

1984 • 133 citations

Multiple sequence alignment

1986 • 128 citations

Nucleotide sequence of the Bacillus subtilis tryptophan operon

1985 • 122 citations

An active proteolytic derivative of the .alpha. subunit of tryptophan synthase. Identification of the site of cleavage and characterization of the fragments

1979 • 112 citations

Assessment of secondary-structure prediction of proteins comparison of computerized chou-fasman method with others

1983 • 109 citations

Structure of the nucleotide‐binding domain in the β‐subunit of Escherichia coli F₁‐ATPase

1986 • 108 citations

Invariant features of the structure of pancreatic ribonuclease

1977 • 89 citations

Guanidine hydrochloride-induced unfolding of the .alpha. subunit of tryptophan synthase and of the two .alpha. proteolytic fragments: evidence for stepwise unfolding of the two .alpha. domains

1982 • 88 citations

Structure of glycolate oxidase from spinach

1985 • 87 citations

Tryptophan Biosynthetic Genes in Eukaryotic Microorganisms

1986 • 81 citations

A method for the simultaneous alignment of three or more amino acid sequences

1986 • 64 citations

Nucleotide sequence of the genes for tryptophan synthase in Pseudomonas aeruginosa.

1986 • 62 citations

Multiparameter kinetic study on the unfolding and refolding of bovine carbonic anhydrase B

1980 • 55 citations

Comparison of the nucleotide sequence of trpA and sequences immediately beyond the trp operon of Klebsiella aerogenes, Salmonella typhimurium and Escherichia coli

1981 • 53 citations

The mechanism of self-assembly of the multi-enzyme complex tryptophan synthase from Escherichia coli.

1984 • 50 citations

Characterization of an early intermediate in the folding of the .alpha. subunit of tryptophan synthase by hydrogen exchange measurement

1985 • 47 citations

Evolutionary similarity among peptide segments is a basis for prediction of protein folding

1986 • 46 citations

Twisted hyperboloid (strophoid) as a model of β-barrels in proteins

1984 • 42 citations

Crystallization and preliminary X-ray crystallographic data of the tryptophan synthase alpha 2 beta 2 complex from Salmonella typhimurium.

1985 • 42 citations

Small‐Angle X‐Ray Scattering Studies of Tryptophan Synthase from Escherichia coli and Its α and β₂ Subunits

1982 • 41 citations

Complete nucleotide and deduced amino acid sequences of theBrevibacterium lactofermentumtryptophan operon

1986 • 41 citations

Triose phosphate isomerase, pyruvate kinase and other α/β-barrel enzymes

1983 • 40 citations

Steady‐State Kinetic Studies of the Synthesis of Indoleglycerol Phosphate Catalyzed by the α Subunit of Tryptophan Synthase from Escherichia coli

1976 • 39 citations

In vitro mutagenesis and overexpression of the Escherichia coli trpA gene and the partial characterization of the resultant tryptophan synthase mutant alpha-subunits.

1986 • 37 citations

Limited proteolysis of N-(5′-phosphoribosyl)anthranilate isomerase: Indoleglycerol phosphate synthase from Escherichia coli yields two different enzymically active, functional domains

1980 • 31 citations

Purification and Comparison of the N‐(5′‐Phosphoribosyl)anthranilic Acid Isomerase/Indole‐3‐glycerol Phosphate Synthetase of Tryptophan Biosynthesis from Three Species of Enterobacteriaceae

1970 • 30 citations

The Quarternary Structure of Tryptophan Synthase from Escherichia coli

1983 • 30 citations

Selection for new codons corresponding to position 234 of the tryptophan synthetase alpha chain of Escherichia coli

1983 • 26 citations

Reaction of phenylglyoxal and {p-hydroxyphenyl}glyoxal with arginines and cysteines in the .alpha. subunit of tryptophan synthase

1984 • 25 citations

Structural and Functional Roles of the Cysteine Residues in the α Subunit of the Escherichia coli Tryptophan Synthetase

1971 • 24 citations

Effect of single amino acid substitutions on the protease susceptibility of tryptophan synthase a subunit

1985 • 21 citations

The domain structure of tryptophan synthase. A neutron scattering study

1985 • 19 citations

The tryptophan synthase α2β2 complex: A comparison of the reactivity of amino groups in the α and β2 subunits and in the complex by differential labeling studies

1984 • 5 citations