Medical significance of peroxisome proliferator-activated receptors

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1998 • 1,339 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 • 1,158 citations

Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

1998 • 1,138 citations

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

1998 • 1,109 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

1998 • 733 citations

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

1996 • 715 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1998 • 599 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

Macrophages in Human Atheroma Contain PPARγ

1998 • 536 citations

Peroxisome Proliferator-activated Receptor γ Ligands Are Potent Inhibitors of Angiogenesis in Vitro and in Vivo

1999 • 527 citations

Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner

1998 • 526 citations

Differential activation of adipogenesis by multiple PPAR isoforms.

1996 • 470 citations

Peroxisomal Lipid Metabolism

1994 • 414 citations

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.

1995 • 398 citations

Leptin

1998 • 381 citations

Interdomain communication regulating ligand binding by PPAR-γ

1998 • 344 citations

Control of Human Muscle-type Carnitine Palmitoyltransferase I Gene Transcription by Peroxisome Proliferator-activated Receptor

1998 • 318 citations

The Nuclear Receptors Peroxisome Proliferator-activated Receptor α and Rev-erbα Mediate the Species-specific Regulation of Apolipoprotein A-I Expression by Fibrates

1998 • 302 citations

N-(2-Benzoylphenyl)-<scp>l</scp>-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents

1998 • 300 citations

Mechanism of Action of the Nongenotoxic Peroxisome Proliferators: Role of the Peroxisome Proliferator-Activated Receptor

1998 • 293 citations

Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)

1993 • 284 citations

Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ

1998 • 281 citations

Ligand-independent Activation Domain in the N Terminus of Peroxisome Proliferator-activated Receptor γ (PPARγ)

1997 • 276 citations

Peroxisome Proliferator‐activated Receptor γ Induces Growth Arrest and Differentiation Markers of Human Colon Cancer Cells

1999 • 263 citations

Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism

1997 • 232 citations

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.

1996 • 179 citations

Identification of a Peroxisome Proliferator-responsive Element Upstream of the Human Peroxisomal Fatty Acyl Coenzyme A Oxidase Gene

1996 • 167 citations

Up-Regulation of UCP-2 Gene Expression by PPAR Agonists in Preadipose and Adipose Cells

1997 • 160 citations

Peroxisome Proliferator-activated Receptor Mediates Cross-talk with Thyroid Hormone Receptor by Competition for Retinoid X Receptor

1995 • 149 citations

Fibrates Increase Human REV-ERBα Expression in Liver via a Novel Peroxisome Proliferator-Activated Receptor Response Element

1999 • 141 citations

The Orphan Nuclear Hormone Receptor LXRα Interacts with the Peroxisome Proliferator-activated Receptor and Inhibits Peroxisome Proliferator Signaling

1996 • 111 citations

Down-Regulation of Cytochrome P450 2C Family Members and Positive Acute-Phase Response Gene Expression by Peroxisome Proliferator Chemicals

1998 • 102 citations

L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor γ

1999 • 101 citations

Troglitazone

1997 • 89 citations

Pathophysiology of peroxisomal beta-oxidation.

1989 • 62 citations

Mechanisms and clinical effects of thiazolidinediones

1997 • 59 citations

PPAR: a Key Nuclear Factor in Nutrient / Gene Interactions?

1995 • 51 citations

Identification of an extended half‐site motif required for the function of peroxisome proliferator‐activated receptor α

1997 • 48 citations

Effect of various n − 3/n − 6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial β-oxidation

1993 • 47 citations

Perturbation of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: mechanisms and lack of relevance for human health (review).

1998 • 47 citations

YM268 Increases the Glucose Uptake, Cell Differentiation, and mRNA Expression of Glucose Transporter in 3T3-L1 Adipocytes

1998 • 42 citations

The peroxisome proliferators are hepatocyte mitogens in chemically- defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis

1998 • 28 citations

Cross-talk between Orphan Nuclear Hormone Receptor RZRα and Peroxisome Proliferator-activated Receptor α in Regulation of the Peroxisomal Hydratase-Dehydrogenase Gene

1998 • 18 citations

Liver Peroxisomal Oxidizing Activities in Physiological and Pathological Conditions

1987 • 9 citations

The Peroxisome Proliferator-Activated Receptor α (PPARα) Ligand WY 14,643 Does Not Interfere with Leukotriene B4 Induced Adhesion of Neutrophils to Endothelial Cells

1998 • 5 citations