PPAR: a Key Nuclear Factor in Nutrient / Gene Interactions?

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

1976 • 1,136 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

The Early Evolution of Eukaryotes: A Geological Perspective

1992 • 673 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

1965 • 599 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor

1993 • 523 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily.

1990 • 483 citations

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

1992 • 454 citations

MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

1990 • 428 citations

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

1993 • 394 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

1992 • 388 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

1988 • 357 citations

Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation

1989 • 356 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit.

1989 • 316 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Peroxisome proliferation and hepatocarcinogenesis

1987 • 310 citations

Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia

1972 • 308 citations

The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

1993 • 308 citations

Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression

1991 • 303 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors

1989 • 293 citations

Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)

1993 • 284 citations

Metabolic aspects of peroxisomal β-oxidation

1991 • 277 citations

Regulation of lipogenic enzyme gene expression by nutrients and hormones

1994 • 268 citations

PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene

1993 • 265 citations

Origins of genes: "big bang" or continuous creation?

1992 • 260 citations

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus

1989 • 251 citations

Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.

1993 • 245 citations

Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.

1992 • 233 citations

Peroxisome proliferator and retinoid signalingpathways co-regulate preadipocyte phenotype and survival.

1994 • 227 citations

The three-dimensional structure of P2 myelin protein.

1988 • 221 citations

Control of transcription activation by steroid hormone receptors

1992 • 218 citations

Induction of peroxisomal β-oxidation in rat liver by high-fat diets

1980 • 215 citations

Effects of N-3 Fatty Acids on Lipid Metabolism

1990 • 212 citations

Steroid and related receptors

1993 • 199 citations

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

1991 • 198 citations

Transcriptional control of metabolic regulation genes by carbohydrates

1994 • 191 citations

A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation?

1992 • 164 citations

Changes in Peroxisomal Fatty Acid Oxidation in the Diabetic Rat Liver

1981 • 163 citations

Peroxisome proliferator-activated receptors: finding the orphan a home

1994 • 157 citations

Identification of Two mPPAR Related Receptors and Evidence for the Existence of Five Subfamily Members

1993 • 154 citations

Peroxisomes: Biology and Importance in Toxicology and Medicine

2007 • 125 citations

A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.

1984 • 122 citations

Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors

1993 • 122 citations

Detection of a nafenopin-binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds

1983 • 119 citations

Receptor-mediated mechanisms of peroxisome proliferators

1992 • 114 citations

Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids

1993 • 106 citations

Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway

1993 • 104 citations

Drugs and Lipid Metabolism

1973 • 102 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling.

1993 • 99 citations

Genomic organization of the human thyroid hormone receptor α (c-erbA-1) gene

1991 • 92 citations

Genomic organization and alternative promoter usage of the two thyroid hormone receptor beta genes in Xenopus laevis.

1992 • 92 citations

Peroxisome Proliferator‐Activated Receptors and Lipid Metabolism^a

1993 • 87 citations

Differential induction and regulation of peroxisomal enzymes: Predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens

1989 • 86 citations

Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes

1991 • 82 citations

On the mechanism of induction of the enzyme systems for peroxisomal β-oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil

1988 • 80 citations

Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?

1993 • 80 citations

The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat

1992 • 79 citations

FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.

1994 • 78 citations

Peroxisomes

2013 • 77 citations

Regulation of Gene Expression by Fatty Acids and Fibric Acid Derivatives: An Integrative Role for Peroxisome Prolif erator Activated Receptors

1992 • 76 citations

COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily

1990 • 74 citations

Localization of human ERBA2 to the 3p22----3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer.

1988 • 70 citations

Structure of the Mouse Peroxisome Proliferator Activated Receptor α Gene

1994 • 68 citations

Genomic organization of the retinoic acid receptor gamma gene

1991 • 67 citations

Thyromimetic effect of peroxisomal proliferators in rat liver

1991 • 63 citations

Nuclear Hormone Receptors

2007 • 60 citations

Liver fatty acid-binding protein: specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators.

1994 • 58 citations

Clobuzarit: Species differences in the morphological and biochemical response of the liver following chronic administration

1984 • 56 citations

How do thyroid hormone receptors bind to structurally diverse response elements?

1994 • 56 citations

Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver

1991 • 54 citations

Xenobiotic acyl-coenzymes A: critical intermediates in the biochemical pharmacology and toxicology of carboxylic acids

1984 • 53 citations

The role of fat in human nutrition

1946 • 45 citations

Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes

1992 • 44 citations

Role of peroxisomes in mammalian metabolism

1992 • 41 citations

Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation

1992 • 40 citations

Effects of chlorophenoxyisobutyrate on the synthesis and metabolism of cholesterol in man

1971 • 34 citations

Evidence for the Presence of Two Active Forms of Cytosolic 3,5,3′-Triiodo-L-thyronine (T3)-binding Protein (CTBP) in Rat Kidney

1989 • 33 citations

Evidence for a negative modulating effect of erucic acid on the peroxisomal β-oxidation enzyme system and biogenesis in rat liver

1983 • 29 citations

Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains.

1992 • 24 citations

Specific repression of transthyretin gene expression in rat liver by a peroxisome proliferator clofibrate

1992 • 24 citations

The effect of clofibrate on amphibian hepatic peroxisomes

1991 • 16 citations

Therapeutic significance of hypolipidemic and antiatherosclerotic drugs

1977 • 15 citations

Metabolic and Nutritional Aspects of Long-Chain Fatty Acids of Marine Origin

1989 • 8 citations