Interleukin 12 Stimulates IFN-γ–Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance

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2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The Three Es of Cancer Immunoediting

2004 • 2,781 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Immunosuppressive Strategies that are Mediated by Tumor Cells

2006 • 1,662 citations

In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes

2004 • 1,192 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 • 871 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

Interleukin-12: Biological Properties and Clinical Application

2007 • 569 citations

The biology of IL-12: coordinating innate and adaptive immune responses

2003 • 558 citations

Tregs and rethinking cancer immunotherapy

2007 • 532 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Frontline: Neuropilin‐1: a surface marker of regulatory T cells

2004 • 447 citations

Human CD4⁺CD25⁺Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens

2004 • 436 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

Clinical Trials: IL-12 Deaths: Explanation and a Puzzle

1995 • 333 citations

Activation requirements for the induction of CD4⁺CD25⁺ T cell suppressor function

2004 • 307 citations

Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines

2005 • 275 citations

Regulatory T cells in immune surveillance and treatment of cancer

2006 • 257 citations

Vascular Endothelial Growth Factor Blockade Reduces Intratumoral Regulatory T Cells and Enhances the Efficacy of a GM-CSF–Secreting Cancer Immunotherapy

2006 • 232 citations

Antigen-Specific FoxP3-Transduced T-Cells Can Control Established Type 1 Diabetes

2005 • 231 citations

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.

1995 • 215 citations

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

1993 • 177 citations

Real-time imaging of ligand-induced IKK activation in intact cells and in living mice

2005 • 160 citations

Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8+ T Effectors

2006 • 131 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

IL-12 Deaths: Explanation and a Puzzle

1995 • 114 citations

Accelerated chemically induced tumor development mediated by CD4 ⁺ CD25 ⁺ regulatory T cells in wild-type hosts

2005 • 111 citations

Comparative Analysis of Regulatory and Effector T Cells in Progressively Growing versus Rejecting Tumors of Similar Origins

2006 • 103 citations

IFN-γ Controls the Generation/Activation of CD4+CD25+ Regulatory T Cells in Antitumor Immune Response

2005 • 102 citations

Phase II Clinical Trial of Interleukin-12 in Patients with Relapsed and Refractory Non-Hodgkin’s Lymphoma and Hodgkin’s Disease

2004 • 101 citations

Immune Regulation by Self-Reactive T Cells is Antigen Specific

2004 • 76 citations

The Generation of CD25+CD4+ Regulatory T Cells That Prevent Allograft Rejection Does Not Compromise Immunity to a Viral Pathogen

2005 • 73 citations

IL-12 p40 Homodimer-Dependent Macrophage Chemotaxis and Respiratory Viral Inflammation Are Mediated through IL-12 Receptor β1

2003 • 69 citations

Randomized Phase II Study of Interleukin-12 in Combination with Rituximab in Previously Treated Non-Hodgkin's Lymphoma Patients

2006 • 55 citations

Control of cell cycle progression in human mesothelioma cells treated with gamma interferon

2001 • 30 citations

Mouse models of acute promyelocytic leukemia

2001 • 27 citations

Induction of apoptosis by anti-CD3 epsilon F(ab')2 in antigen receptor transgenic murine T cells activated by specific peptide.

1996 • 19 citations

Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.

2005 • 13 citations

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