Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside

AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet

1993 • 8,468 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Phyto-oestrogens and Western Diseases

1997 • 1,280 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Mammalian lignan production from various foods

1991 • 646 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Comparative Study of Human and Rat Mammary Tumorigenesis

1990 • 585 citations

Mammary gland neoplasia in long-term rodent studies.

1996 • 410 citations

Origin of lignans in mammals and identification of a precursor from plants

1982 • 398 citations

Production and metabolism of lignans by the human faecal flora

1985 • 385 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

Hormonal Predictors of Prostate Cancer: A Meta-Analysis

2000 • 310 citations

The Role of the Insulin-like Growth Factor System in Human Cancer

1996 • 295 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

SHORT COMMUNICATION: Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis

1996 • 266 citations

Antitumorigenic effect of a mammalian lignan precursor from flaxseed

1996 • 260 citations

Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells

1996 • 225 citations

The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activity

1996 • 214 citations

The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis

1992 • 158 citations

The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis

1991 • 141 citations

Urinary lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder

1994 • 141 citations

In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen.

1993 • 123 citations

Dose-dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed.

1996 • 123 citations

Tamoxifen reduces serum insulin-like growth factor I (IGF-I)

1992 • 115 citations

Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats

1998 • 114 citations

Role of IGF-I in normal mammary development

1998 • 93 citations

Exposure to flaxseed or its lignan component during different developmental stages influences rat mammary gland structures

1999 • 88 citations

Dose Effects of Flaxseed and Its Lignan on N-Methyl-N-Nitrosourea-Induced Mammary Tumorigenesis in Rats

1999 • 82 citations

Dose, Timing, and Duration of Flaxseed Exposure Affect Reproductive Indices and Sex Hormone Levels in Rats

1999 • 78 citations

Role of insulin-like growth factors in steroid modulated proliferation

1994 • 77 citations

Steroid excretion during the reproductive cycle and in pregnancy of the vervet monkey (Cercopithecus aethiopus pygerythrus)

1980 • 72 citations

Chronic Exposure to Secoisolariciresinol Diglycoside Alters Lignan Disposition in Rats

1998 • 61 citations

The Isolation of β-Hydroxy-β-methylglutaric Acid from the Seed of Flax (Linum usitatissimum)¹

1954 • 59 citations

Distribution of Circulating Insulin-Like Growth Factor-I (IGF-I) into Tissues*

1991 • 36 citations

Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: A prospective paired cohort study

1998 • 34 citations

Insulin-like growth factor-I gene expression during development and estrous cycle in the rat uterus

1991 • 23 citations

Role of insulin-like growth factor-related peptides in the estradiol-, prolactin-, and progesterone-stimulated growth of N-nitrosomethylurea-induced rat mammary tumors in soft agar.

1990 • 10 citations

Effect of DMBA on the expression of prolactin receptors and IGF1 genes in rat mammary gland

1991 • 9 citations