Pathogenic characterization of 1-methyl-1-nitrosourea-induced mammary carcinomas in the rat

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Comparative Study of Human and Rat Mammary Tumorigenesis

1990 • 585 citations

Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins.

1985 • 495 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

Biological and molecular bases of mammary carcinogenesis.

1987 • 341 citations

Activation of ras Oncogenes Preceding the Onset of Neoplasia

1990 • 261 citations

Tumours of the mammary gland.

1973 • 179 citations

Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea.

1981 • 145 citations

Dose-responsive induction of mammary gland carcinomas by the intraperitoneal injection of 1-methyl-1-nitrosourea.

1991 • 142 citations

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

1994 • 141 citations

Oncogene detection at the single cell level.

1988 • 89 citations

Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels.

1990 • 48 citations

Induction of mammary gland carcinomas by the subcutaneous injection of 1-methyl-1-nitrosourea.

1983 • 48 citations

Ha-ras oncogene activation in mammary glands of N-methyl-N-nitrosourea-treated rats genetically resistant to mammary adenocarcinogenesis.

1992 • 42 citations

Effect of excess dietary iron on the promotion stage of 1-methyl-1- nitrosourea-induced mammary carcinogenesis: pathogenetic characteristics and distribution of iron

1994 • 25 citations

Rasmay mediate mammary cancer promotion by high fat

1995 • 21 citations

Nonrandom distribution of O6-methylguanine in H-ras gene sequence from DNA modified with N-methyl-N-nitrosourea

1993 • 15 citations

Activation of the c‐Ha‐ras‐1 proto‐oncogene by methylation in vitro with α‐acetoxy‐N‐nitrosodimethylamine

1989 • 6 citations

Inhibition of Tumor Metastasis by a Circulating Suppressor Factor

1993 • 5 citations