ATP: an extracellular signaling molecule between neurons and glia

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

Tripartite synapses: glia, the unacknowledged partner

1999 • 2,319 citations

Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling

1990 • 1,820 citations

Glutamate-mediated astrocyte–neuron signalling

1994 • 1,688 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Direct Signaling from Astrocytes to Neurons in Cultures of Mammalian Brain Cells

1994 • 1,000 citations

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

2000 • 967 citations

Neuronal activity triggers calcium waves in hippocampal astrocyte networks

1992 • 818 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

ATP Released from Astrocytes Mediates Glial Calcium Waves

1999 • 794 citations

Connexins regulate calcium signaling by controlling ATP release

1998 • 767 citations

Induction of myelination in the central nervous system by electrical activity.

1996 • 646 citations

Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons

1993 • 622 citations

Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses

1997 • 492 citations

Calcium Waves in Retinal Glial Cells

1997 • 461 citations

SNARE Protein-Dependent Glutamate Release from Astrocytes

2000 • 442 citations

Signalling via ATP in the nervous system

1994 • 441 citations

Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K+ channel block

1996 • 401 citations

ATP-Mediated Glia Signaling

2000 • 391 citations

Modulation of Neuronal Activity by Glial Cells in the Retina

1998 • 381 citations

Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells

1992 • 373 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

1994 • 354 citations

Synaptic corelease of ATP and GABA in cultured spinal neurons

1999 • 352 citations

P2X₃ is expressed by DRG neurons that terminate in inner lamina II

1998 • 335 citations

Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells.

1996 • 327 citations

Mouse microglial cells express a plasma membrane pore gated by extracellular ATP.

1996 • 319 citations

Voltage gating and permeation in a gap junction hemichannel.

1996 • 304 citations

Response of Schwann Cells to Action Potentials in Development

2000 • 267 citations

CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli

1997 • 263 citations

Calcium‐dependent currents in cultured rat dorsal root ganglion neurones are inhibited by an adenosine analogue.

1986 • 256 citations

Stimulation-dependent release of adenosine triphosphate from hippocampal slices

1989 • 245 citations

The Neurobiology of Schwann Cells

1999 • 244 citations

Molecular mechanisms of microglial activation

1996 • 241 citations

Modulation of Synaptic Efficacy and Synaptic Depression by Glial Cells at the Frog Neuromuscular Junction

1998 • 237 citations

Schwann cells induce and guide sprouting and reinnervation of neuromuscular junctions

1996 • 235 citations

Transmitter release increases intracellular calcium in perisynaptic schwann cells in situ

1992 • 228 citations

Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors

1996 • 222 citations

Calcium signaling of glial cells along mammalian axons

1993 • 204 citations

Mitogenic Signaling by ATP/P2Y Purinergic Receptors in Astrocytes: Involvement of a Calcium-Independent Protein Kinase C, Extracellular Signal-Regulated Protein Kinase Pathway Distinct from the Phosphatidylinositol-Specific Phospholipase C/Calcium Pathway

1999 • 203 citations

P2Y₁Purinoceptor-Mediated Ca²⁺Signaling and Ca²⁺Wave Propagation in Dorsal Spinal Cord Astrocytes

2000 • 195 citations

Neuronal coupling and uncoupling in the developing nervous system

1995 • 186 citations

Failure of the Cystic Fibrosis Transmembrane Conductance Regulator to Conduct ATP

1996 • 184 citations

Cell type‐specific ATP‐activated responses in rat dorsal root ganglion neurons

1999 • 181 citations

Control of Myelination by Specific Patterns of Neural Impulses

1998 • 166 citations

New insights into molecular structure and function of ecto-nucleotidases in the nervous system

1998 • 164 citations

Activation of P2‐purinoreceptors triggered Ca2+ release from InsP3‐sensitive internal stores in mammalian oligodendrocytes.

1995 • 153 citations

Rat astroglial P2Z (P2X7) receptors regulate intracellular calcium and purine release

1996 • 150 citations

Both adenosine A1- and A2-receptors are required to stimulate microglial proliferation.

1996 • 140 citations

Characterization of cultured dorsal root ganglion neuron P2X receptors

1999 • 138 citations

Neurally evoked calcium transients in terminal Schwann cells at the neuromuscular junction.

1992 • 138 citations

Purinergic receptors and their activation by endogenous purines at perisynaptic glial cells of the frog neuromuscular junction

1995 • 134 citations

Spontaneous and evoked activity of fetal primary afferents in vivo

1987 • 122 citations

Synaptic regulation of glial protein expression in vivo

1994 • 114 citations

Stimulation of reactive astrogliosis in vivo by extracellular adenosine diphosphate or an adenosine A₂ receptor agonist

1994 • 113 citations

Cystic Fibrosis Transmembrane Conductance Regulator–associated ATP Release Is Controlled by a Chloride Sensor

1998 • 109 citations

P2 receptor-mediated proliferative effects on astrocytes in vivo

1999 • 108 citations

Nerve impulse-enhanced release of amino acids from non-synaptic regions of peripheral and central nerve trunks of bullfrog

1975 • 102 citations

P2 purinoceptors in rat cortical astrocytes: Expression, calcium-imaging and signalling studies

1996 • 101 citations

Adenosine A_2B‐receptor‐mediated cyclic AMP accumulation in primary rat astrocytes

1994 • 100 citations

Two different ionotropic receptors are activated by ATP in rat microglia

1999 • 100 citations

Long-term activation of capacitative Ca2+ entry in mouse microglial cells

1998 • 99 citations

P_2Y purinoceptor subtypes recruit different Mek activators in astrocytes

2000 • 96 citations

Electron-immunocytochemical localization of P2X 1 receptors in the rat cerebellum

1998 • 94 citations

Neuroligand-evoked calcium-dependent release of excitatory amino acids from Schwann cells

1995 • 91 citations

Distribution of [3H]α,β-methylene ATP binding sites in rat brain and spinal cord

1994 • 86 citations

Interleukin-1 Enhances the ATP-Evoked Release of Arachidonic Acid from Mouse Astrocytes

1997 • 86 citations

Axonal activation-induced calcium transients in myelinating Schwann cells, sources, and mechanisms

1995 • 82 citations

Extracellular ATP‐induced currents in astrocytes: Involvement of a cation channel

1994 • 78 citations

Discussion

1996 • 77 citations

Characterization of ATP release from cultures enriched in cholinergic amacrine-like neurons

1999 • 76 citations

A novel P₂‐purinoceptor expressed by a subpopulation of astrocytes from the dorsal spinal cord of the rat

1995 • 71 citations

ATP stimulates release of excitatory amino acids from cultured Schwann cells

1997 • 61 citations

Modulation by adenosine of GABA‐activated current in rat dorsal root ganglion neurons

1997 • 58 citations

ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors

1998 • 58 citations

ATP induces Ca2+ release from IP3-sensitive Ca2+ stores exclusively in large DRG neurones

1997 • 58 citations

Schwann cell ATP‐mediated calcium increases in vitro and in situ are dependent on contact with neurons

1995 • 53 citations

Gap junctions in the developing nervous system.

1995 • 53 citations

The Trophic Effects of Purines and Purinergic Signaling in Pathologic Reactions of Astrocytes

1998 • 52 citations

Meningeal cells can communicate with astrocytes by calcium signaling

2000 • 49 citations

Differences in the sensitivity to purinergic stimulation of myelinating and non-myelinating Shwann cells in peripheral human and rat nerve

1998 • 49 citations

Physiological Effects Of Extracellular Nucleotides In The Inner Ear

2000 • 47 citations

Extracellular ATP increases intracellular calcium in cultured adult Schwann cells

1996 • 46 citations

Potentiated cAMP Rise in Metabotropically Stimulated Rat Cultured Astrocytes by a Ca²⁺‐related A_l/k₂ Adenosine Receptor Cooperation

1996 • 45 citations

Confocal calcium imaging reveals an ionotropic P2 nucleotide receptor in the paranodal membrane of rat Schwann cells

1999 • 45 citations

Activity-dependent intracellular Ca 2+ transients in unmyelinated nerve fibres of the isolated adult rat vagus nerve

1998 • 42 citations

Release of Adenine Nucleotide from Nerve Axons

1964 • 37 citations

Chapter 12 Quantal ATP release from motor nerve endings and its role in neurally mediated depression

1999 • 37 citations

Multiple signal transduction pathways lead to extracellular ATP‐stimulated mitogenesis in mammalian cells: I. Involvement of protein kinase C–dependent and –independent pathways

1991 • 34 citations

Role of action potentials and calcium influx in ATP- and UDP-induced noradrenaline release from rat cultured sympathetic neurones

1999 • 33 citations

THE FUNCTIONS OF ATP RECEPTORS IN THE HIPPOCAMPUS

1998 • 33 citations

ATP acting on P2Y receptors triggers calcium mobilization in Schwann cells at the neuroelectrocyte junction in skate

1997 • 27 citations

Adenosine A1 receptor-mediated inhibition of cyclic AMP accumulation in type-2 but not type-1 rat astrocytes

1996 • 20 citations