Both adenosine A1- and A2-receptors are required to stimulate microglial proliferation.

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

1992 • 649 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

The Physiological Role of Adenosine In The Central Nervous System

1985 • 628 citations

Neuroprotective role of adenosine in cerebral ischaemia

1992 • 450 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Macrophages and the Nervous System

1991 • 429 citations

Adenosine and the concept of ‘retaliatory metabolites’

1984 • 422 citations

Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre

1982 • 390 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Colony-stimulating factors as promoters of ameboid microglia

1988 • 323 citations

Adenosine and Brain Ischemia

1995 • 298 citations

Adenosine inhibits the accumulation of cyclic AMP in cultured brain cells

1978 • 251 citations

Growth control of cultured microglia

1992 • 250 citations

Lipopolysaccharide-free conditions in primary astrocyte cultures allow growth and isolation of microglial cells

1989 • 217 citations

Activation of phospholipase C via adenosine receptors provides synergistic signals for secretion in antigen-stimulated RBL-2H3 cells. Evidence for a novel adenosine receptor.

1990 • 190 citations

Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo

1990 • 184 citations

THE ROLE OF CYCLIC AMP IN CELL PROLIFERATION: A CRITICAL ASSESSMENT OF THE EVIDENCE

1983 • 165 citations

Levels of adenosine and adenine nucleotides in slices of rat hippocampus

1984 • 160 citations

Stimulation by thyrotropin and cyclic AMP of the proliferation of quiescent canine thyroid cells cultured in a defined medium containing insulin

1983 • 150 citations

Inhibition of [³H] glutamate release from rat hippocam pal slices by L‐phenylisopropyladenosine

1985 • 144 citations

ATP and its metabolite adenosine act synergistically to mobilize intracellular calcium via the formation of inositol 1,4,5-trisphosphate in a smooth muscle cell line.

1992 • 132 citations

Adenosine: the brain's natural anticonvulsant?

1986 • 106 citations

Calcium, cyclic AMP and protein kinase C ? partners in mitogenesis

1987 • 86 citations

Microglial mitogens are produced in the developing and injured mammalian brain.

1991 • 85 citations

Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane

1986 • 77 citations

Purinergic stimulation of cell division and differentiation: Mechanisms and pharmacological implications

1992 • 77 citations

Mechanisms leading to adenosine-stimulated proliferation of microvascular endothelial cells

1990 • 75 citations

Characterization and transduction mechanisms of purinoceptors in activated rat microglia

1994 • 59 citations

Indications for P2-purinoceptor subtypes in guinea pig smooth muscle

1988 • 54 citations

ATP and A1 adenosine receptor agonists mobilize intracellular calcium and activate K+ and Cl- currents in normal and cystic fibrosis airway epithelial cells.

1993 • 54 citations

A possible role for cyclic AMP in the initiation of DNA synthesis by isoproterenol‐activated parotid gland cells

1980 • 50 citations

Coupling of a transfected human brain A₁ adenosine receptor in CHO‐K1 cells to calcium mobilisation via a pertussis toxin‐sensitive mechanism

1994 • 44 citations