Hydroxyurea transport across the blood–brain and blood–cerebrospinal fluid barriers of the guinea‐pig

British HIV Association guidelines for the treatment of HIV‐1‐infected adults with antiretroviral therapy 2008

2008 • 1,106 citations

Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins

1990 • 454 citations

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

1968 • 423 citations

Changes to AIDS dementia complex in the era of highly active antiretroviral therapy

1999 • 422 citations

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

1997 • 396 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Hydroxyurea as an Inhibitor of Human Immunodeficiency Virus-Type 1 Replication

1994 • 320 citations

Localization of the Organic Anion Transporting Polypeptide 2 (Oatp2) in Capillary Endothelium and Choroid Plexus Epithelium of Rat Brain

1999 • 300 citations

Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication.

1993 • 287 citations

High Viral Load in the Cerebrospinal Fluid and Brain Correlates with Severity of Simian Immunodeficiency Virus Encephalitis

1999 • 226 citations

Control of SIV Rebound Through Structured Treatment Interruptions During Early Infection

2000 • 192 citations

Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.

2001 • 178 citations

An overview of the clinical experience with hydroxyurea.

1992 • 155 citations

Measurement of Solute Transport Across the Blood–Brain Barrier in the Perfused Guinea Pig Brain: Method and Application to N‐Methyl‐α‐Aminoisobutyric Acid

1986 • 152 citations

Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid

2000 • 143 citations

A placebo-controlled trial of didanosine plus stavudine, with and without hydroxyurea, for HIV infection

1998 • 142 citations

Blood—Brain Barrier Is Involved in the Efflux Transport of a Neuroactive Steroid, Dehydroepiandrosterone Sulfate, via Organic Anion Transporting Polypeptide 2

2000 • 141 citations

Pharmacokinetics and Pharmacodynamics of Hydroxyurea

1998 • 109 citations

Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

1997 • 106 citations

British HIV Association (BHIVA) guidelines for the treatment of HIV‐infected adults with antiretroviral therapy

2001 • 106 citations

Combination of a Drug Targeting the Cell with a Drug Targeting the Virus Controls Human Immunodeficiency Virus Type 1 Resistance

1997 • 96 citations

Studies of hydroxyurea administered by continuous infusion. Toxicity, pharmacokinetics, and cell synchronization

1980 • 83 citations

Treatment of high risk or recurrent meningiomas with hydroxyurea

2002 • 79 citations

Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression

2001 • 74 citations

A Pilot Study of Hydroxyurea among Patients with Advanced Human Immunodeficiency Virus (HIV) Disease Receiving Chronic Didanosine Therapy: Canadian HIV Trials Network Protocol 080

1997 • 74 citations

Passage of a δ‐Opioid Receptor Selective Enkephalin, [<scp>d</scp>‐Penicillamine^2,5]Enkephalin, Across the Blood‐Brain and the Blood‐Cerebrospinal Fluid Barriers

1996 • 74 citations

Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance, and clinical manifestations of encephalopathy

2002 • 63 citations

The distribution of the anti‐HIV drug, 2′3′‐dideoxycytidine (ddC), across the blood–brain and blood–cerebrospinal fluid barriers and the influence of organic anion transport inhibitors

2002 • 59 citations

Stavudine

1999 • 57 citations

British HIV Association (BHIVA) guidelines for the treatment of HIV‐infected adults with antiretroviral therapy

2000 • 55 citations

Hydroxyurea (NSC-32065) in biologic fluids: dose-concentration relationship.

1965 • 51 citations

The transport of the anti‐HIV drug, 2′,3′‐didehydro‐3′‐deoxythymidine (D4T), across the blood‐brain and blood‐cerebrospinal fluid barriers

1998 • 50 citations

Hydroxychloroquine, hydroxycarbamide, and didanosine as economic treatment for HIV-1

2002 • 49 citations

Evidence of a Source of HIV Type 1 within the Central Nervous System by Ultraintensive Sampling of Cerebrospinal Fluid and Plasma

2000 • 47 citations

Treatment of Human Immunodeficiency Virus Infection with Hydroxyurea: Virologic and Clinical Evaluation

1996 • 46 citations

Effect of 17β-Estradiol-d-17β-Glucuronide on the Rat Organic Anion Transporting Polypeptide 2-Mediated Transport Differs Depending on Substrates

2002 • 46 citations

Pharmacokinetics of Hydroxyurea in Patients Infected with Human Immunodeficiency Virus Type I

1996 • 45 citations

HIV in the brain

2001 • 45 citations

Discussion

1998 • 39 citations

Identification of a saturable uptake system for deoxyribonucleosides at the blood-brain and blood-cerebrospinal fluid barriers

1996 • 37 citations

Control of HIV during a structured treatment interruption in chronically infected individuals with vigorous T cell responses

2002 • 34 citations

Mechanisms by which 2′,3′‐dideoxyinosine (ddI) crosses the guinea‐pig CNS barriers; relevance to HIV therapy

2003 • 33 citations

Comparison of Human Immunodeficiency Virus Type 1 RNA Sequence Heterogeneity in Cerebrospinal Fluid and Plasma

2000 • 33 citations

Rationale for the Use of Hydroxyurea as an Anti-Human Immunodeficiency Virus Drug

2000 • 32 citations

Structure-activity relationships of a series of [D-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability.

1997 • 29 citations

A specific enzyme assay for aminopeptidase M in rat brain

1992 • 27 citations

Transport characteristics of the anti-human immunodeficiency virus nucleoside analog, abacavir, into brain and cerebrospinal fluid.

2001 • 23 citations

Colorimetric determination of hydroxyurea in human serum using high-performance liquid chromatography

1998 • 19 citations

Evidence that the antitumor agent hydroxyurea enters mammalian cells by a diffusion mechanism

1986 • 19 citations

Transport characteristics of two carcinostatic compounds, hydroxyurea and hadacidin, with rat small intestine

1972 • 5 citations

First-Order Drug Decay

1987 • 3 citations