Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

2000 • 2,694 citations

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

IgG Fc Receptors

2001 • 1,667 citations

Glycosylation and the Immune System

2001 • 1,515 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG

1985 • 1,136 citations

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

2001 • 1,108 citations

The C‐type lectin superfamily in the immune system

1998 • 1,022 citations

FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype

1997 • 760 citations

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

1999 • 751 citations

Glycosylation changes of IgG associated with rheumatooid arthritis can activate complement via the mannose-binding protein

1995 • 742 citations

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

1997 • 698 citations

The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex

2000 • 697 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region.

1989 • 519 citations

Multiple Roles for the Major Histocompatibility Complex Class I– Related Receptor FcRn

2000 • 471 citations

Humanization of an antibody directed against IgE.

1993 • 461 citations

A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.

1991 • 460 citations

Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics

2000 • 441 citations

Biological significance of carbohydrate chains on monoclonal antibodies.

1983 • 427 citations

Refined Structure of an Intact IgG2a Monoclonal Antibody^,

1997 • 424 citations

Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

2000 • 416 citations

Crystallographic structure of an intact IgG1 monoclonal antibody 1 1Edited by I. A. Wilson

1998 • 414 citations

The IgG Fc receptor family

1998 • 398 citations

The Structure of a Human Type III Fcγ Receptor in Complex with Fc

2001 • 346 citations

IgG‐Fc‐mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation

1998 • 325 citations

Fc receptors are required in passive and active immunity to melanoma

1998 • 322 citations

Expression of GnTIII in a recombinant anti‐CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FCγRIII

2001 • 315 citations

Effect of glycosylation on antibody function: implications for genetic engineering

1997 • 311 citations

Fc RECEPTORS AND THEIR INTERACTIONS WITH IMMUNOGLOBULINS

1996 • 309 citations

Clinical trials of antibody therapy

2000 • 297 citations

Localization of the binding site for the human high-affinity Fc receptor on IgG

1988 • 287 citations

The effect of the removal of sialic acid, galactose and total carbohydrate on the functional activity of Campath-1H

1995 • 277 citations

Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma

1997 • 249 citations

Therapeutic inhibition of the complement system.

1998 • 242 citations

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors

2000 • 190 citations

Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing FcγRI and/or FcγRII receptors

1989 • 183 citations

Recombinant human IgG molecules lacking Fcγ receptor I binding and monocyte triggering activities

1999 • 179 citations

Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions

1995 • 177 citations

Effects of galactose depletion from oligosaccharide chains on immunological activities of human IgG.

1989 • 162 citations

A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins

1990 • 158 citations

Effect of C2-Associated Carbohydrate Structure on Ig Effector Function: Studies with Chimeric Mouse-Human IgG1 Antibodies in Glycosylation Mutants of Chinese Hamster Ovary Cells

1998 • 155 citations

A high-throughput microscale method to release N-linked oligosaccharides from glycoproteins for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis

1998 • 153 citations

Characterization of Complex Formation by Humanized Anti-IgE Monoclonal Antibody and Monoclonal Human IgE

1995 • 146 citations

Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site‐directed mutagenesis

1994 • 117 citations

Molecular basis for a polymorphism involving Fc receptor II on human monocytes.

1989 • 110 citations

Binding characteristics of dimeric IgG subclass complexes to human neutrophils.

1989 • 108 citations

Galactosylation of human IgG monoclonal anti-D produced by EBV-transformed B-lymphoblastoid cell lines is dependent on culture method and affects Fc receptor-mediated functional activity.

1994 • 104 citations

High-Level Production of Recombinant Proteins in CHO Cells Using a Dicistronic DHFR Intron Expression Vector

1996 • 97 citations

Antibody–cytokine fusion proteins for the therapy of cancer

2001 • 81 citations

Two chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose

1986 • 79 citations

Sialylation of Human IgG-Fc Carbohydrate by Transfected Rat α2,6-Sialyltransferase

2001 • 74 citations

Antibody-dependent cytotoxicity mediated by natural killer cells is enhanced by castanospermine-induced alterations of IgG glycosylation

1989 • 62 citations

Blood clearance in the rat of a recombinant mouse monoclonal antibody lacking the N-linked oligosaccharide side chains of the CH2 domains

1992 • 57 citations

[19] Glycosidase inhibitors in study of glycoconjugates

1994 • 49 citations

The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

1998 • 41 citations

The glycosylation pattern of humanized IgGI antibody (D1.3) expressed in CHO cells.

1997 • 40 citations

Introduction: bispecific antibodies

2001 • 34 citations

Comparative biological properties of a recombinant chimeric anti-carcinoma mAb and a recombinant aglycosylated variant

1992 • 31 citations

Interaction of aglycosyl immunoglobulins with the IgG Fc transport receptor from neonatal rat gut: Comparison of deglycosylation by tunicamycin treatment and genetic engineering

1992 • 30 citations

Simple Differentiation between Core-Fucosylated and Nonfucosylated Glycans by Capillary Electrophoresis

1996 • 28 citations

On the interaction between agalactosyl IgG and Fcγ receptors

1996 • 27 citations

Role of processing of N-linked oligosaccharides in control of immunoglobulin secretion from rat hybridomas

1987 • 7 citations

Simultaneous inhibition of multiple steps in the processing of N-linked oligosaccharides does not impair immunoglobulin secretion from rat hybridoma cells.

1988 • 5 citations