High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

2000 • 2,694 citations

Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)

1980 • 2,158 citations

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

F<scp>c</scp>RECEPTOR BIOLOGY

1997 • 1,219 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype

1997 • 760 citations

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

1999 • 751 citations

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

1997 • 698 citations

The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex

2000 • 697 citations

p185^HER2 Monoclonal Antibody Has Antiproliferative Effects In Vitro and Sensitizes Human Breast Tumor Cells to Tumor Necrosis Factor

1989 • 672 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Humanization of an antibody directed against IgE.

1993 • 461 citations

Refined Structure of an Intact IgG2a Monoclonal Antibody^,

1997 • 424 citations

Mapping of the C1q Binding Site on Rituxan, a Chimeric Antibody with a Human IgG1 Fc

2000 • 416 citations

Crystallographic structure of an intact IgG1 monoclonal antibody 1 1Edited by I. A. Wilson

1998 • 414 citations

The IgG Fc receptor family

1998 • 398 citations

Crystal structure of the complex of rat neonatal Fc receptor with Fc

1995 • 382 citations

Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.

1970 • 375 citations

Fc receptors are required in passive and active immunity to melanoma

1998 • 322 citations

Fc RECEPTORS AND THEIR INTERACTIONS WITH IMMUNOGLOBULINS

1996 • 309 citations

Analysis of the pH Dependence of the Neonatal Fc Receptor/Immunoglobulin G Interaction Using Antibody and Receptor Variants

1995 • 308 citations

Localization of the binding site for the human high-affinity Fc receptor on IgG

1988 • 287 citations

Analysis of Acidic Oligosaccharides and Glycopeptides by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

1996 • 281 citations

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule

1986 • 275 citations

The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region.

1991 • 261 citations

Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma

1997 • 249 citations

Increasing the serum persistence of an IgG fragment by random mutagenesis

1997 • 236 citations

FcRn: the MHC class I-related receptor that is more than an IgG transporter

1997 • 218 citations

Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc gamma receptor I and influence the synthesis of its oligosaccharide chains.

1996 • 214 citations

Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.

1999 • 190 citations

Recombinant human IgG molecules lacking Fcγ receptor I binding and monocyte triggering activities

1999 • 179 citations

Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations

1999 • 178 citations

Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions

1995 • 177 citations

Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1.

1997 • 169 citations

Fc receptors for mouse IgG1 on human monocytes: polymorphism and role in antibody-induced T cell proliferation.

1984 • 164 citations

A high-throughput microscale method to release N-linked oligosaccharides from glycoproteins for matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis

1998 • 153 citations

Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes.

1994 • 151 citations

The IgG Fc Contains Distinct Fc Receptor (FcR) Binding Sites: The Leukocyte Receptors FcγRI and FcγRIIa Bind to a Region in the Fc Distinct from That Recognized by Neonatal FcR and Protein A

2000 • 147 citations

Characterization of Complex Formation by Humanized Anti-IgE Monoclonal Antibody and Monoclonal Human IgE

1995 • 146 citations

Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor

1994 • 140 citations

Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.

1991 • 130 citations

Involvement of Fcγ receptor IIIA genotypes in susceptibility to rheumatoid arthritis

2000 • 123 citations

Three-dimensional structure of a human immunoglobulin with a hinge deletion.

1993 • 122 citations

Crystal structure of the soluble form of the human Fcgamma -receptor IIb: a new member of the immunoglobulin superfamily at 1.7Aresolution

1999 • 121 citations

Localisation of the monocyte-binding region on human immunoglobulin G

1986 • 121 citations

Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site‐directed mutagenesis

1994 • 117 citations

Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fcγ receptor

1992 • 111 citations

Molecular basis for a polymorphism involving Fc receptor II on human monocytes.

1989 • 110 citations

Binding characteristics of dimeric IgG subclass complexes to human neutrophils.

1989 • 108 citations

High-Level Production of Recombinant Proteins in CHO Cells Using a Dicistronic DHFR Intron Expression Vector

1996 • 97 citations

Green fluorescent protein as a second selectable marker for selection of high producing clones from transfected CHO cells

2000 • 97 citations

A novel role for the Fc receptor gamma subunit: enhancement of Fc gamma R ligand affinity.

1996 • 78 citations

A Single-Chain IL-12 IgG3 Antibody Fusion Protein Retains Antibody Specificity and IL-12 Bioactivity and Demonstrates Antitumor Activity

1999 • 77 citations

Chimeric Fc receptors identify functional domains of the murine high affinity receptor for IgG.

1991 • 75 citations

Oligosaccharide‐protein interactions in IgG can modulate recognition by Fcγ receptors

1995 • 71 citations

Catabolism of the Murine IgGl Molecule: Evidence that Both CH2‐CH3 Domain Interfaces are Required for Persistence of IgGl in the Circulation of Mice

1994 • 71 citations

Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men

2000 • 63 citations

The IgG Binding Site of Human FcγRIIIB Receptor Involves CC′ and FG Loops of the Membrane-proximal Domain

1996 • 62 citations

Molecular definition of interaction sites on human IgG for Fc receptors (huFcγR)

1990 • 61 citations

Humanized Antibodies as Potential Therapeutic Drugs

1998 • 59 citations

Multiple binding sites on the CH2 domain of IgG for mouse FcγR11

1992 • 54 citations

Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men

2000 • 51 citations

The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

1998 • 41 citations

Novel Fc gamma receptor I family gene products in human mononuclear cells.

1992 • 40 citations

Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations

1999 • 38 citations

Antibodies come back from the brink

1998 • 37 citations

Molecular recognition of antibody (IgG) by cellular Fc receptor (FcRI)

1988 • 36 citations

Ligand inhibition studies on the role of Fc receptors in antibody-dependent cell-mediated cytotoxicity

1984 • 33 citations

Interaction of human monocyte Fc gamma receptors with rat IgG2b. A new indicator for the Fc gamma RIIa (R-H131) polymorphism.

1995 • 33 citations

Identification of a secondary Fc gamma RI binding site within a genetically engineered human IgG antibody.

1993 • 21 citations

Redirected cellular cytotoxicity employing bispecific antibodies and other multifunctional binding proteins

1997 • 17 citations

Cell-Mediated Effects of Immunoglobulins

1997 • 13 citations

Characterization of FcR Ig-Binding Sites and Epitope Mapping

1994 • 8 citations

Fc receptors on lymphocytes and K cells

1984 • 4 citations