Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.

2000 • 475 citations

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

1998 • 448 citations

Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes.

1998 • 408 citations

Patterns of p53 G->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

2001 • 371 citations

Cytosine methylation determines hot spots of DNA damage in the human P 53 gene

1997 • 335 citations

Targeting of Lung Cancer Mutational Hotspots by Polycyclic Aromatic Hydrocarbons

2000 • 310 citations

p53 Mutations in non-small cell lung cancer in Japan: Association between mutations and smoking

1992 • 280 citations

Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases

2000 • 247 citations

Molecular epidemiology of human cancer risk: gene-environment interactions andp53 mutation spectrum in human lung cancer

1999 • 207 citations

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers

1998 • 167 citations

SHORT COMMUNICATION: G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and relati DNA methylating and pyridyloxobutylating agents

1993 • 151 citations

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.

1998 • 120 citations

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1993 • 118 citations

Human lung cancer and p53 : The interplay between mutagenesis and selection

2000 • 102 citations

Vitamin C prevents cigarette smoke–induced oxidative damage in vivo

2000 • 100 citations

Dose-dependent differences in the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in Chinese hamster V-79 cells.

1993 • 91 citations

p53 mutations in defined structural and functional domains are related to poor clinical outcome in non-small cell lung cancer patients.

2000 • 88 citations

Cytosine Methylation in a CpG Sequence Leads to Enhanced Reactivity with Benzo[a]pyrene Diol Epoxide That Correlates with a Conformational Change

1999 • 77 citations

Chronic cigarette smoking induces an oxidantantioxidant imbalance in the testis.

2000 • 40 citations

Benzo[a]pyrene‐induced mutagenesis of p53 hot‐spot codons 248 and 249 in human hepatocytes

1995 • 30 citations

Dose-dependent mutation profile in the c-Ha-ras proto-oncogene of skin tumors in mice initiated with benzo[a]pyrene

1999 • 27 citations

Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.

2000 • 15 citations