Brain Adipocytokine Action and Metabolic Regulation

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 7,795 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,744 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,391 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

2005 • 2,774 citations

Adiponectin and Adiponectin Receptors

2005 • 2,543 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

2002 • 2,081 citations

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

2005 • 2,028 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Leptin

2000 • 1,368 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

The Leptin Receptor

1997 • 1,300 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

2004 • 1,188 citations

Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity

2004 • 1,156 citations

Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

2002 • 1,132 citations

Obesity Wars

2004 • 1,119 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

2005 • 1,053 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

OBESE, A NEW MUTATION IN THE HOUSE MOUSE*

1950 • 1,020 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

2002 • 969 citations

Resistin Is an Inflammatory Marker of Atherosclerosis in Humans

2005 • 891 citations

Recombinant Human Leptin in Women with Hypothalamic Amenorrhea

2004 • 877 citations

Lipotoxic Diseases

2002 • 835 citations

T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin

2004 • 827 citations

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

2002 • 825 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Adiponectin acts in the brain to decrease body weight

2004 • 797 citations

PTP1B Regulates Leptin Signal Transduction In Vivo

2002 • 785 citations

Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans

2001 • 748 citations

Effects of parabiosis of obese with diabetes and normal mice

1973 • 728 citations

Regulation of Fasted Blood Glucose by Resistin

2004 • 720 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2004 • 632 citations

Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

2005 • 621 citations

A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation

2001 • 597 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 562 citations

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight

2005 • 557 citations

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

2003 • 555 citations

Molecular and anatomical determinants of central leptin resistance

2005 • 543 citations

The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men

2003 • 541 citations

Selective deletion of leptin receptor in neurons leads to obesity

2001 • 533 citations

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

2004 • 492 citations

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

2004 • 489 citations

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

2003 • 419 citations

Partial leptin deficiency and human adiposity

2001 • 402 citations

Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting

2004 • 343 citations

Role of resistin in diet-induced hepatic insulin resistance

2004 • 322 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development*

1999 • 320 citations

Role of resistin in diet-induced hepatic insulin resistance

2004 • 305 citations

Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones

2004 • 305 citations

Fasting Induces a Large, Leptin-Dependent Increase in the Intrinsic Action Potential Frequency of Orexigenic Arcuate Nucleus Neuropeptide Y/Agouti-Related Protein Neurons

2005 • 291 citations

Role of resistin in obesity, insulin resistance and Type II diabetes

2005 • 277 citations

Adenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats

2004 • 253 citations

Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats

2003 • 246 citations

Relatively low plasma leptin concentrations precede weight gain in Pima Indians

1997 • 243 citations

Glucocorticoids and 11beta-Hydroxysteroid Dehydrogenase in Adipose Tissue

2004 • 241 citations

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

2004 • 238 citations

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

2003 • 237 citations

Adipose Tissue Intracrinology: Potential Importance of Local Androgen/Estrogen Metabolism in the Regulation of Adiposity

2002 • 236 citations

Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin

2006 • 225 citations

Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells

2006 • 202 citations

A Promoter Genotype and Oxidative Stress Potentially Link Resistin to Human Insulin Resistance

2003 • 192 citations

Effect of Leptin Replacement on Brain Structure in Genetically Leptin-Deficient Adults

2005 • 174 citations

Body Fat Distribution and Cortisol Metabolism in Healthy Men: Enhanced 5β-Reductase and Lower Cortisol/Cortisone Metabolite Ratios in Men with Fatty Liver

2003 • 172 citations

Central actions of adipocyte hormones

2005 • 163 citations

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance

2005 • 151 citations

Arcuate Nucleus Ablation Prevents Fasting-Induced Suppression of ProTRH mRNA in the Hypothalamic Paraventricular Nucleus

1998 • 138 citations

The long-term effect of recombinant methionyl human leptin therapy on hyperandrogenism and menstrual function in female and pituitary function in male and female hypoleptinemic lipodystrophic patients

2005 • 132 citations

Obesity Genes: Beneficial Effects in Heterozygous Mice

1979 • 119 citations

Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity

2004 • 116 citations

Melanocortin-independent Effects of Leptin on Hepatic Glucose Fluxes

2004 • 113 citations

An update on visfatin/pre-B cell colony-enhancing factor, an ubiquitously expressed, illusive cytokine that is regulated in obesity

2006 • 112 citations

Heterozygosity forLep^oborLepr^dbaffects body composition and leptin homeostasis in adult mice

1998 • 105 citations

Central administration of resistin promotes short-term satiety in rats

2005 • 100 citations

Area Postrema Neurons Are Modulated by the Adipocyte Hormone Adiponectin

2006 • 99 citations

Leptin and the Neuroendocrinology of Fasting

1999 • 89 citations

Weight Loss Increases 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in Human Adipose Tissue

2004 • 86 citations

Fat-cell mass, serum leptin and adiponectin changes during weight gain and loss in yellow-bellied marmots (Marmota flaviventris)

2004 • 82 citations

Recombinant Human Leptin in Women With Hypothalamic Amenorrhea

2005 • 79 citations

Involvement of a humoral factor in regulation of body weight in parabiotic rats

1977 • 71 citations

Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis

2004 • 65 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2006 • 61 citations

Anatomy of the adipose organ

2000 • 54 citations

Serum Leptin Levels in Wild and Captive Populations of Baboons (Papio): Implications for the Ancestral Role of Leptin

2001 • 51 citations

Plasma leptin concentrations in Pima Indians living in drastically different environments.

1999 • 46 citations

Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

2006 • 46 citations

Body composition of lean and obese Zucker rats in parabiosis.

1987 • 44 citations

Traditional versus agricultural lifestyle among Shuar women of the Ecuadorian Amazon: Effects on leptin levels

2004 • 36 citations

Do Leptin Levels Predict Weight Gain?-A 5-Year Follow-Up Study in Mauritius

1998 • 36 citations

Steroid hormone interconversions in human adipose tissue in vivo

1992 • 35 citations

Waveform generation in Rhamphichthys rostratus (L.) (Teleostei, Gymnotiformes)

1994 • 32 citations

Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting

2001 • 27 citations

Serum Leptin Levels in Wild and Captive Populations of Baboons (Papio): Implications for the Ancestral Role of Leptin

2001 • 20 citations

Cellular aspects of fuel mobilization and selection in white adipocytes

1995 • 14 citations