Do Leptin Levels Predict Weight Gain?-A 5-Year Follow-Up Study in Mauritius

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Leptin: The Tale of an Obesity Gene

1996 • 987 citations

Diabetes Mellitus: Report of a WHO Study Group.

1986 • 869 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Critical Variables in the Radioimmunoassay of Serum Insulin Using the Double Antibody Technic

1965 • 734 citations

Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro

1996 • 716 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

1997 • 443 citations

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.

1995 • 436 citations

Serum Leptin in Children With Obesity: Relationship to Gender and Development

1996 • 394 citations

Plasma Leptin and Insulin Relationships in Obese and Nonobese Humans

1996 • 389 citations

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

1995 • 367 citations

Insulin resistance associated with lower rates of weight gain in Pima Indians.

1991 • 322 citations

The ob Gene and Insulin: A Relationship Leading to Clues to the Understanding of Obesity

1995 • 275 citations

Fasting Hyperinsulinemia Is a Predictor of Increased Body Weight Gain and Obesity in Pima Indian Children

1997 • 266 citations

Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM

1996 • 249 citations

Relatively low plasma leptin concentrations precede weight gain in Pima Indians

1997 • 243 citations

Changes in population cholesterol concentrations and other cardiovascular risk factor levels after five years of the non-communicable disease intervention programme in Mauritius

1995 • 237 citations

Abdominal Obesity and Physical Inactivity as Risk Factors for NIDDM and Impaired Glucose Tolerance in Indian, Creole, and Chinese Mauritians

1991 • 234 citations

Identification of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat Mutations

1996 • 225 citations

Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study

1996 • 218 citations

The Weight-Reducing Effect of an Intracerebroventricular Bolus Injection of Leptin in Genetically Obese fa/fa Rats: Reduced Sensitivity Compared With Lean Animals

1996 • 206 citations

High Prevalence of NIDDM and Impaired Glucose Tolerance in Indian, Creole, and Chinese Mauritians

1990 • 200 citations

Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects

1996 • 165 citations

Low Plasma Leptin in Response to Dietary Fat in Diabetes- and Obesity-Prone Mice

1997 • 125 citations

Recombinant OB-Gene Product Reduces Food-Intake in Fasted Mice

1995 • 117 citations

Relation between Plasma Leptin Levels and Measures of Body Fat in Identical Twins Discordant for Obesity

1997 • 105 citations

Incidence, increasing prevalence, and predictors of change in obesity and fat distribution over 5 years in the rapidly developing population of Mauritius.

1996 • 99 citations

Predictors of weight change in a bi-ethnic population. The San Antonio Heart Study.

1994 • 88 citations

Leptin inhibits insulin binding in isolated rat adipocytes

1997 • 86 citations

Correlates and predictors of weight loss in young adults: the CARDIA study.

1996 • 77 citations

High fasting insulin levels associated with lower rates of weight gain in persons with normal glucose tolerance: the San Luis Valley Diabetes Study.

1995 • 77 citations

Absence of Linkage of Obesity and Energy Metabolism to Markers Flanking Homologues of Rodent Obesity Genes in Pima Indians

1996 • 56 citations

Relationship of insulin resistance to weight gain in nondiabetic Asian Indian, Creole, and Chinese Mauritians

1996 • 34 citations

Energetic pursuit of leptin function

1997 • 21 citations