p21-ras effector domain mutants constructed by "cassette" mutagenesis.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

In yeast, RAS proteins are controlling elements of adenylate cyclase

1985 • 1,142 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product

1988 • 402 citations

Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites

1985 • 270 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes

1982 • 179 citations

Linker Tailing: Unphosphorylated Linker Oligonucleotides for Joining DNA Termini

1984 • 154 citations

Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.

1987 • 101 citations

Oncogenes and Cancer: The p21rasGenes

1984 • 97 citations

Induction of Neurite Formation in PC12 Cells by Microinjection of Proto-Oncogenic Ha-ras Protein Preincubated with Guanosine-5′-O-(3-Thiotriphosphate)

1987 • 95 citations

An Adenylate Cyclase from Saccharomyces cerevisiae That Is Stimulated by RAS Proteins with Effector Mutations

1988 • 50 citations

The ras gene family.

1986 • 37 citations

Transduction of host cellular sequences by a retroviral shuttle vector

1986 • 32 citations

Mutational Analysis ofarasCatalytic Domain

1986 • 10 citations