Phase I Trial of a Genetically Engineered Interleukin-2 Fusion Toxin (DAB486IL-2) as a 6 Hour Intravenous Infusion in Patients with Hematologic Malignancies

Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis.

1988 • 343 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Recombinant Toxins for Cancer Treatment

1991 • 308 citations

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells.

1985 • 237 citations

Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

1987 • 236 citations

Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

1988 • 220 citations

Phase I trial of an interleukin-2 (IL-2) fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor

1992 • 159 citations

Lack of efficacy of high-dose leucovorin and fluorouracil in patients with advanced pancreatic adenocarcinoma.

1991 • 127 citations

Interleukin 2 receptor‐targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin‐related interleukin 2 fusion protein into cells

1990 • 117 citations

Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers.

1993 • 87 citations

Immunophenotypes of Reed-Sternberg cells: a study of 19 cases of Hodgkin's disease in plastic-embedded sections

1989 • 84 citations

IL-2 receptor expression in human lymphoid lesions. Immunohistochemical study of 166 cases.

1987 • 83 citations

A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest [published erratum appears in Blood 1991 Oct 1;78(7):1899]

1991 • 82 citations

Multichain Interleukin-2 Receptor: A Target for Immunotherapy in Lymphoma

1989 • 75 citations

Expression of interleukin-2 receptor beta subunit in hematopoietic malignancies

1989 • 72 citations

Expression of interleukin-2 receptor beta subunit in hematopoietic malignancies

1989 • 64 citations

Clinical activity of a cytotoxic fusion protein in the treatment of cutaneous T-cell lymphoma.

1993 • 59 citations

The proliferative response of B cell chronic lymphocytic leukemia to interleukin 2: functional characterization of the interleukin 2 membrane receptors

1987 • 53 citations

Diagnostic and clinical importance of interleukin‐2 receptor alpha chain expression on non‐T‐cell acute leukaemia cells

1992 • 45 citations

Demonstration of high-affinity interleukin-2 receptors on B-chronic lymphocytic leukemia cells: Functional and structural characterization

1990 • 37 citations

Interleukin 2 stimulates chronic lymphocytic leukemia colony formation in vitro

1985 • 36 citations

Interleukin 2 stimulates chronic lymphocytic leukemia colony formation in vitro

1985 • 28 citations

Presence of a p70 IL-2-binding peptide on leukemic cells from various hemopoietic lineages.

1989 • 26 citations

Lymphocyte populations and TAC-antigen in diffuse B-cell lymphomas

1986 • 23 citations

Functional p75 interleukin‐2 receptor expression on the fresh blast cells in childhood acute lymphoblastic leukemia with natural killer cell properties

1991 • 19 citations

Characterization of interleukin-2 receptors expressed on acute leukemic B cells

1987 • 11 citations

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