Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides.

1988 • 445 citations

Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5.

1986 • 295 citations

The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

1986 • 245 citations

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1989 • 238 citations

Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

1988 • 227 citations

Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity.

1987 • 225 citations

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

1987 • 173 citations

Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

1984 • 172 citations

Enzymatic amplification of translation inhibition of rabbit β-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents

1987 • 164 citations

Reselution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100

1978 • 156 citations

Influence of 5' proximal secondary structure on the translational efficiency of eukaryotic mRNAs and on their interaction with initiation factors.

1986 • 149 citations

Rate of degradation of [α]- and [β]-oligodeoxynucleotides inXenopusoocytes. Implications for anti-messenger strategies

1987 • 143 citations

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

1986 • 142 citations

Antisense oligonucleotide-directed cleavage of mRNA in Xenopus oocytes and eggs.

1988 • 136 citations

Α-DNA II. Synthesis of unnatural Α-anomeric oligodeoxyribonucleotides containing the four usual bases and study of their substrate activities for nucleases

1987 • 130 citations

Hybridization arrest of globin synthesis in rabbit reticulocyte lysates and cells by oligodeoxyribonucleoside methylphosphonates

1985 • 125 citations

Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion.

1987 • 121 citations

α-DNA VI: comparative study of α- and β-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition

1987 • 121 citations

Comparative hybrid arrest by tandem antisense oligodeoxyribonucleotides or oligodeoxyribonucleoside methylpbosphonates in a cell-free system

1988 • 110 citations

Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents.

1986 • 107 citations

Photochemical cross-linking of psoralen-derivatized oligonucleoside methylphosphonates to rabbit globin messenger RNA

1988 • 100 citations

An acridine-linked oligodeoxynucleotide targeted to the common 5' end of trypanosome mRNAs kills cultured parasites

1987 • 87 citations

Distinct Ribonuclease H Activities in Calf Thymus

1975 • 71 citations

Destabilization of messenger RNA/complementary DNA duplexes by the elongating 80 S ribosome.

1986 • 70 citations

α-DNA IX: parallel annealing of α-anomeric oligodeoxyribonucleotides to natural mRNA is required for interference in RNase H mediated hydrolysis and reverse transcription

1989 • 65 citations

Oligo-[α]-deoxynucleotides covalently linked to an intercalating agent. Double helices with parallel strands are formed with complementary oligo-[β]-deoxynucleotides

1987 • 63 citations

Anti-messenger oligodeoxynucleotides: specific inhibition of rabbit β-globin synthesis in wheat germ extracts and Xenopus oocytes

1986 • 52 citations

Destruction of a translationally controlled mRNA in Xenopus oocytes delays progesterone-induced maturation.

1988 • 48 citations

Comparative activity of α- and β-anomeric oligonucleotides on rabbit β globin synthesis: Inhibitory effect of cap targeted α-oligonucleotides

1989 • 48 citations

Inhibition of rabbit β-Globin synthesis by complementary oligonucleotides: Identification of mRNA sites sensitive to inhibition

1988 • 46 citations

Evaluation of N-ras oncogene anti-sense, sense and nonsense sequence methylphosphonate oligonucleotide analogues.

1988 • 42 citations

Modulation of drug resistance in a daunorubicin resistant subline with oligonucleoside methylphosphonates.

1989 • 34 citations

Comparative inhibition of ras p21 protein synthesis with phosphorus-modified antisense oligonucleotides.

1989 • 30 citations

Effect of RNA secondary structure and modified bases on the inhibition of trypanosomatid protein synthesis in cellfree extracts by antisense oligodeoxynucleotides

1990 • 25 citations