Yeast artificial chromosome-based genome mapping: Some lessons from Xq24–q28

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1991 • 3,422 citations

A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.

1989 • 2,011 citations

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

1991 • 1,482 citations

Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) n

1991 • 903 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

Fragile X Genotype Characterized by an Unstable Region of DNA

1991 • 794 citations

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones

1990 • 650 citations

Report of the committee on the genetic constitution of the X chromosome (Part 1 of 3)

1990 • 597 citations

Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources.

1989 • 578 citations

Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction.

1990 • 454 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

Random-clone strategy for genomic restriction mapping in yeast.

1986 • 423 citations

Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents.

1990 • 408 citations

Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.

1991 • 331 citations

Isolation of Single-Copy Human Genes from a Library of Yeast Artificial Chromosome Clones

1989 • 316 citations

Chromosomal Region of the Cystic Fibrosis Gene in Yeast Artificial Chromosomes: A Model for Human Genome Mapping

1990 • 238 citations

The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs

1989 • 230 citations

A 3.5 genome equivalent multi access YAC library: construction, characterisation, screening and storage

1990 • 221 citations

Isolation of Sequences that Span the Fragile X and Identification of a Fragile X-Related CpG Island

1991 • 174 citations

Detection and characterization of chimeric yeast artificial-chromosome clones

1991 • 160 citations

Wilms Tumor Locus on 11p13 Defined by Multiple CpG Island-Associated Transcripts

1990 • 143 citations

Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors

1990 • 139 citations

Jumping libraries and linking libraries: the next generation of molecular tools in mammalian genetics

1986 • 131 citations

Human Gene Mapping 10

1990 • 129 citations

A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis

1991 • 124 citations

Mapping the Drosophila Genome with Yeast Artificial Chromosomes

1989 • 121 citations

Second-generation approach to the construction of yeast artificial-chromosome libraries

1990 • 94 citations

Genetics by gel electrophoresis: the impact of pulsed field gel electrophoresis on mammalian genetics

1987 • 88 citations

Human Xq24-Xq28: approaches to mapping with yeast artificial chromosomes.

1990 • 85 citations

The human HPRT gene on a yeast artificial chromosome is functional when transferred to mouse cells by cell fusion

1991 • 84 citations

Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2

1991 • 79 citations

Construction of human chromosome 21-specific yeast artificial chromosomes.

1989 • 70 citations

Yeast artificial chromosomes with 200- to 800-kilobase inserts of human DNA containing HLA, V kappa, 5S, and Xq24-Xq28 sequences.

1989 • 67 citations

Yeast artificial chromosomes containing human Xq24–Xq28 DNA: Library construction and representation of probe sequences

1990 • 64 citations

Alu-primed polymerase chain reaction for regional assignment of 110 yeast artificial chromosome clones from the human X chromosome: identification of clones associated with a disease locus.

1991 • 63 citations

A rodent‐human hybrid containing Xq24‐qter translocated to a hamster chromosome expresses the Xq27 folate‐sensitive fragile site

1986 • 63 citations

Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci.

1991 • 62 citations

A YAC contig across the fragile X site defines the region of fragility

1991 • 41 citations

In situ hybridization to cytogenetic bands of yeast artificial chromosomes covering 50% of human Xq24-Xq28 DNA.

1991 • 38 citations

Cloning of the HLA class II region in yeast artificial chromosomes.

1991 • 36 citations

Stable integration and expression in mouse cells of yeast artificial chromosomes harboring human genes.

1991 • 36 citations

Human glucose-6-phosphate dehydrogenase gene carried on a yeast artificial chromosome encodes active enzyme in monkey cells

1990 • 35 citations

Molecular approaches to genome analysis: a strategy for the construction of ordered overlapping clone libraries

1987 • 34 citations

Identification of new human repetitive sequences: characterization of the corresponding cDNAs and their expression in embryonal carcinoma cells

1989 • 33 citations

Linkage homogeneity near the fragile X locus in normal and fragile X families

1991 • 12 citations

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